Results 151 to 157 of about 1,936 (157)

Mouse Homologue of Human HLA-DO Does Not Preempt Autoimmunity but Controls Murine Gammaherpesvirus MHV68

The Journal of Immunology, 2021
Abstract H2-O (human HLA-DO) is a relatively conserved nonclassical MHC class II (MHCII)–like molecule. H2-O interaction with human HLA-DM edits the repertoire of peptides presented to TCRs by MHCII. It was long hypothesized that human HLA-DM inhibition by H2-O provides protection from autoimmunity by preventing binding of the high ...
Jean Lee, Emily Cullum, Kyle Stoltz, Niklas Bachmann, Zoe Strong, Danielle D Millick, Lisa K Denzin, Anthony Chang, Vera Tarakanova, Alexander V Chervonsky, Tatyana Golovkina   +10 more
openaire   +2 more sources

MHV68 latency modulates host immune responses to H1N1 influenza virus (49.9)

The Journal of Immunology, 2011
Abstract Human gammaherpesviruses such as Epstein-Barr virus (EBV) are clinically important pathogens, as diseases caused by gammaherpesvirus infection are a significant human health concern. Additionally, latent gammaherpesvirus infection is widespread, and can have a profound effect on subsequent immune responses.
Fumitake Saito, Toshihiro Ito, Matthew Schaller, William Carson, Cory Hogaboam, Nicholas Lukacs, Theodore Standiford, Rosemary Rochford, Steven Kunkel   +8 more
openaire   +1 more source

302 CIDOFOVIR THERAPY REDUCES GAMMAHERPESVIRUS (MHV68)-INDUCED PULMONARY FIBROSIS IN INTERFERON-GAMMA RECEPTOR-DEFICIENT MICE.

Journal of Investigative Medicine, 2006
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disorder of unknown cause. Several studies demonstrate an association between pulmonary infection with the herpesvirus, EBV, and IPF. Based on those observations, we have developed a mouse model in which interferon-gamma receptor-deficient (IFNgR 2/2 ) mice infected with herpesvirus ...
A. L. Mora, E. Torres-González, J. Xu, J. Ritzenthaler, J. Roman, M. Rojas, K. L. Brigham, A. Stecenko   +7 more
openaire   +1 more source

Abstract 329: Myxomavirus-derived Serpin Prolongs Survival and Reduces Vasculitis in MHV68 Infected Mice by Enhancing IL-10

Arteriosclerosis, Thrombosis, and Vascular Biology, 2013
Background Lethal viral infections produce widespread inflammation with vascular leaking, clotting and bleeding (DIC), and high mortality. Serine proteases in clot-forming (thrombotic) and clot-dissolving (thrombolytic) cascades are activated by a cytokine storm and also induce systemic inflammation. Normal host
Hao Chen, Donghang Zheng, Liu Liying, Bartee Mee Y, Jennifer Davids, Jennifer Davids, Colin Macaulay, Grant McFadden, Robert Thoburn, David A Lomas, Herbert W Virgin, Alexandra Lucas   +11 more
openaire   +1 more source

The endosomal Toll-like receptors 7 and 9 cooperate in detection of MHV68 infection.

2018
Murine gammaherpesvirus 68 (MHV68) is an amenable small animal model for study of the human pathogens Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus. Here, we have characterized the roles of the endosomal TLR escort protein UNC93B, endosomal TLR7, 9, and 13, and cell surface TLR2 in MHV68 detection. We found that the interferon α (IFNα)
Bussey, Kendra A, Murthy, Sripriya, Reimer, Elisa, Chan, Baca, Hatesuer, Bastian, Schughart, Klaus, Glaunsinger, Britt, Adler, Heiko, Brinkmann, Melanie M   +8 more
openaire   +2 more sources

MHV68 is responsible for immune maturation in sequentially infected mice 4791

The Journal of Immunology
Abstract Description   Up to 80% of therapies found effective in mice are not effective in humans due to factors such as differences in immune maturation, microbiota diversity, and genetic expression.
Crystal L. Lovato, Megan Tierney Baldridge, Yuhao Li, Jerome Molleston   +3 more
openaire   +1 more source

SEPARATING ANTIVIRAL RESPONSE FROM HETEROLOGOUS ALLOREACTIVITY: Vβ4 CD8 T CELLS MAY NOT DIRECTLY CAUSE ALLOGRAFT REJECTION IN LATENT MHV68 INFECTION

Transplantation Journal, 2010
J. Beus, S. Selvaraj, S. Gangappa, A. Kirk, C. Larsen, S. Speck, L. S. Kean   +6 more
openaire   +1 more source