Dissolution Test for Mianserin Hydrochloride in Tablets [PDF]
Drug Analytical Research, 2019 A dissolution test for mianserin hydrochloride in coated tablets containing 30 mg was developed and validated using a fast ultraviolet spectrophotometric method.
Letícia Lenz Sfair +3 more
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Environmental Antidepressants Disrupt Metabolic Pathways in Spirostomum ambiguum and Daphnia magna: Insights from LC-MS-Based Metabolomics [PDF]
MoleculesPharmaceuticals such as fluoxetine, paroxetine, sertraline, and mianserin occur in aquatic environments at low yet persistent concentrations due to their incomplete removal in wastewater treatment plants.
Artur Jędreas +3 more
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Storage stability of hospital-prepared mianserin suppositories: evaluation of residual active ingredient content and bacteriological contamination under different storage conditions [PDF]
Journal of Pharmaceutical Health Care and SciencesBackground Mianserin suppositories are a hospital preparation usable for patients who cannot take oral medication. However, data on the stability of hospital preparations are limited.
Rei Tanaka, Tomoe Ichikawa, Junya Sato
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A New Trick of Old Dogs: Can Kappa Opioid Receptor Antagonist Properties of Antidepressants Assist in Treating Treatment-Resistant Depression (TRD)? [PDF]
PharmaceuticalsBackground/Objectives: Approximately one in five individuals will experience major depressive disorder (MDD), and 30% exhibit resistance to standard antidepressant treatments, resulting in a diagnosis of treatment-resistant depression (TRD). Historically,
Shaul Schreiber +2 more
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Validation in Drosophila of the in silico predicted clomipramine as repurposable for SOD1-ALS [PDF]
NeurotherapeuticsAmyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by progressive motor neuron degeneration and muscle weakness, generally leading to death due to respiratory failure within 2–5 years of symptom onset.
Francesco Liguori +7 more
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Ameliorating calcium homeostasis improves longevity and healthspan in progeroid and naturally aged mice [PDF]
Nature CommunicationsCellular calcium (Ca2+)-regulating systems are compromised during aging-related disorders. Here, we show that disruption of Ca2+ homeostasis leads to the cytoplasmic accumulation of Ca2+ binding protein S100A6, which promotes Hutchinson-Gilford progeria ...
Weifang Xiang +19 more
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Utilization of psychotropic drugs in Serbia from 2006 to 2021: Patterns before and during the COVID-19 pandemic. [PDF]
PLoS ONEBackgroundThe increasing global prevalence of mental disorders as well as a persistent stigma make mental disorders a public health priority. The aim of this study was to provide a comprehensive overview of psychotropic drugs utilization from 2006 to ...
Jelena Filimonovic +18 more
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Неврология, нейропсихиатрия, психосоматика, 2020 The paper systematizes the history of studying the neurochemical activity of mianserin and mirtazapine. The concept of the development of the antidepressant effect of these drugs, by stimulating the release of norepinephrine into the synaptic cleft, is ...
D. S. Danilov +2 more
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Molecules, 2020 The present study aimed to evaluate the effect of the most common antidepressants on aquatic protozoa. Spirostomum ambiguum was used as the model protozoan.
Grzegorz Nałęcz-Jawecki +4 more
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Frontiers in Pharmacology, 2023 Aim: We aimed to systematically evaluate the prevalence and clinical characteristics of adverse events associated with the adaptogens and antidepressant drug interactions in a retrospective chart review.Methodology: A total of 1,816 reports of adverse ...
Marcin Siwek +7 more
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