The enantioselective synthesis of (S)-(+)-mianserin and (S)-(+)-epinastine
Beilstein Journal of Organic Chemistry, 2015 A simple enantioselective synthetic procedure for the preparation of mianserin and epinastine in optically pure form is described. The key step in the synthetic pathway is the asymmetric reduction of the cyclic imine using asymmetric transfer ...
Piotr Roszkowski +2 more
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Mianserin induced periorbital edema: a case report
Psychiatry and Clinical Psychopharmacology, 2017 Objectives: The rare side effects as periorbital edema are worth to discuss most of the times. Periorbital edema is a rare and serious allergic condition. The etiology of this situation might be seen in different status that they are commonly independent
Ibrahim Gundogmus +2 more
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Environmental Antidepressants Disrupt Metabolic Pathways in Spirostomum ambiguum and Daphnia magna: Insights from LC-MS-Based Metabolomics [PDF]
MoleculesPharmaceuticals such as fluoxetine, paroxetine, sertraline, and mianserin occur in aquatic environments at low yet persistent concentrations due to their incomplete removal in wastewater treatment plants.
Artur Jędreas +3 more
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Storage stability of hospital-prepared mianserin suppositories: evaluation of residual active ingredient content and bacteriological contamination under different storage conditions [PDF]
Journal of Pharmaceutical Health Care and SciencesBackground Mianserin suppositories are a hospital preparation usable for patients who cannot take oral medication. However, data on the stability of hospital preparations are limited.
Rei Tanaka, Tomoe Ichikawa, Junya Sato
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A New Trick of Old Dogs: Can Kappa Opioid Receptor Antagonist Properties of Antidepressants Assist in Treating Treatment-Resistant Depression (TRD)? [PDF]
PharmaceuticalsBackground/Objectives: Approximately one in five individuals will experience major depressive disorder (MDD), and 30% exhibit resistance to standard antidepressant treatments, resulting in a diagnosis of treatment-resistant depression (TRD). Historically,
Shaul Schreiber +2 more
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Validation in Drosophila of the in silico predicted clomipramine as repurposable for SOD1-ALS [PDF]
NeurotherapeuticsAmyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by progressive motor neuron degeneration and muscle weakness, generally leading to death due to respiratory failure within 2–5 years of symptom onset.
Francesco Liguori +7 more
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High-performance liquid chromatography–tandem mass spectrometry for simultaneous determination of 23 antidepressants and active metabolites in human serum and its application in therapeutic drug monitoring [PDF]
Frontiers in PharmacologyIntroductionThe incidence and mortality rate from depression are increasing year by year, and depression has become the main cause of global health loss and disability. Currently, the treatment of depression mainly relies on drug intervention.
Jinglong Wang +3 more
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Utilization of psychotropic drugs in Serbia from 2006 to 2021: Patterns before and during the COVID-19 pandemic. [PDF]
PLoS ONEBackgroundThe increasing global prevalence of mental disorders as well as a persistent stigma make mental disorders a public health priority. The aim of this study was to provide a comprehensive overview of psychotropic drugs utilization from 2006 to ...
Jelena Filimonovic +18 more
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Dissolution Test for Mianserin Hydrochloride in Tablets
Drug Analytical Research, 2019 A dissolution test for mianserin hydrochloride in coated tablets containing 30 mg was developed and validated using a fast ultraviolet spectrophotometric method.
Letícia Lenz Sfair +3 more
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