Results 11 to 20 of about 6,114 (196)

Pharmacotherapeutic Management of Depression in Patients With Cancer: A Review of Mechanistic and Clinical Evidence. [PDF]

Cancer Rep (Hoboken)
ABSTRACT Background Depression is a prevalent comorbidity in cancer, yet conventional treatments show inconsistent efficacy. This review sought to provide a mechanism‐based framework for managing cancer‐related depression by exploring its unique pathophysiology and evaluating promising pharmacotherapies based on their alignment with these biological ...
Hajivalizadeh S, Farahmand K, Kazemzadeh K, Hajivalizadeh G, Shamabadi A.   +4 more
europepmc   +2 more sources

Imagery rehearsal therapy and/or mianserin in treatment of refugees diagnosed with PTSD: Results from a randomized controlled trial

Journal of Sleep Research, 2021
Sleep disturbances are frequently part of the symptomatology in refugees with post‐traumatic stress disorder (PTSD). It has been suggested that targeting sleep disturbances may enhance the outcome of PTSD treatment.
Hinuga Sandahl, P. Jennum, L. Baandrup, Erik Lykke Mortensen, J. Carlsson   +4 more
semanticscholar   +1 more source

A Scoping Review of Non-Opioid Therapeutics for Opioid Withdrawal: Translational Relevance to Neonatal Opioid Withdrawal Syndrome (NOWS) Research. [PDF]

Clin Transl Sci
ABSTRACT In the wake of the ongoing opioid epidemic, the incidence of neonatal opioid withdrawal syndrome (NOWS) has surged. While the short‐term effects of NOWS are well‐characterized, long‐term physiological and molecular consequences remain unclear.
Mills-Huffnagle SL, Lowden OM, Sullivan RE, McFadden TE, Nyland JE.   +4 more
europepmc   +2 more sources

The history of mianserin and mirtazapine: study of their neurochemical activity and determination of their position in the classification of antidepressants

Неврология, нейропсихиатрия, психосоматика, 2020
The paper systematizes the history of studying the neurochemical activity of mianserin and mirtazapine. The concept of the development of the antidepressant effect of these drugs, by stimulating the release of norepinephrine into the synaptic cleft, is ...
D. S. Danilov, Yu. G. Tyulpin, V. D. Morozova   +2 more
doaj   +1 more source

Influence of Selected Antidepressants on the Ciliated Protozoan Spirostomum ambiguum: Toxicity, Bioaccumulation, and Biotransformation Products

Molecules, 2020
The present study aimed to evaluate the effect of the most common antidepressants on aquatic protozoa. Spirostomum ambiguum was used as the model protozoan.
Grzegorz Nałęcz-Jawecki, Milena Wawryniuk, Joanna Giebułtowicz, Adam Olkowski, Agata Drobniewska   +4 more
doaj   +1 more source

Harder, better, faster, stronger? Retrospective chart review of adverse events of interactions between adaptogens and antidepressant drugs

Frontiers in Pharmacology, 2023
Aim: We aimed to systematically evaluate the prevalence and clinical characteristics of adverse events associated with the adaptogens and antidepressant drug interactions in a retrospective chart review.Methodology: A total of 1,816 reports of adverse ...
Marcin Siwek, Jarosław Woroń, Jarosław Woroń, Jarosław Woroń, Anna Wrzosek, Anna Wrzosek, Jarosław Gupało, Adrian Andrzej Chrobak   +7 more
doaj   +1 more source

Mianserin suppresses R-spondin 2-induced activation of Wnt/β-catenin signaling in chondrocytes and prevents cartilage degradation in a rat model of osteoarthritis

Scientific Reports, 2019
Aberrant activation of the Wnt/β-catenin signaling pathway promotes the progression of osteoarthritis (OA). We previously reported that R-spondin 2 (Rspo2), an activator of the Wnt/β-catenin signaling, facilitates differentiation of proliferating ...
Toshiaki Okura, B. Ohkawara, Y. Takegami, Mikako Ito, A. Masuda, T. Seki, N. Ishiguro, K. Ohno   +7 more
semanticscholar   +1 more source

Structural Modification of the Antidepressant Mianserin Suggests That Its Anti-inflammatory Activity May Be Independent of 5-Hydroxytryptamine Receptors

Frontiers in Immunology, 2019
Antidepressants are increasingly recognized to have anti-inflammatory properties in addition to their ability to treat major depressive disorders. To explore if engagement of 5-hydroxytryptamine (5-HT) receptors was required for the anti-inflammatory ...
Sandra Sacre, Albert Jaxa-Chamiec, Caroline M. R. Low, Giselle Chamberlain, Cathy Tralau-Stewart   +4 more
doaj   +1 more source

ANTIDEPRESSANT EFFICACY AND SAFETY OF MIANSERIN : A DOUBLE-BLIND, PLACEBO AND AMITRIPTYLINE CONTROLLED COMPARISON STUDY IN DEPRESSION

Psychiatry and Clinical Psychopharmacology, 2021
A double-blind,placebo and amitriptyline-controlled comparison study was performed to evaluate the antidepressant efficacy and safety of mianserin. Patients with DSM-III-R defined major depression (N=60) and dysthymic disorder (n=60) randomly received ...
Mesut Çetin
doaj  

DETERMINATION OF MIANSERIN USING TROPAEOLIN-OOO BY ION PAIR FORMATION

International Journal of Applied Pharmaceutics, 2019
Objective: The present study was aimed at the development of a simple visible spectrophotometric method for the assay of mianserin, a drug used for the treatment of depression.Methods: The method was developed using tropaeolin-ooo (TPooo) as an ion ...
G. Gorumutchu, V. N. Ratnakaram
semanticscholar   +1 more source