Results 11 to 20 of about 2,998 (132)

Environmental Antidepressants Disrupt Metabolic Pathways in Spirostomum ambiguum and Daphnia magna: Insights from LC-MS-Based Metabolomics [PDF]

Molecules
Pharmaceuticals such as fluoxetine, paroxetine, sertraline, and mianserin occur in aquatic environments at low yet persistent concentrations due to their incomplete removal in wastewater treatment plants.
Artur Jędreas, Sylwia Michorowska, Agata Drobniewska, Joanna Giebułtowicz   +3 more
doaj   +2 more sources

Storage stability of hospital-prepared mianserin suppositories: evaluation of residual active ingredient content and bacteriological contamination under different storage conditions [PDF]

Journal of Pharmaceutical Health Care and Sciences
Background Mianserin suppositories are a hospital preparation usable for patients who cannot take oral medication. However, data on the stability of hospital preparations are limited.
Rei Tanaka, Tomoe Ichikawa, Junya Sato
doaj   +2 more sources

A New Trick of Old Dogs: Can Kappa Opioid Receptor Antagonist Properties of Antidepressants Assist in Treating Treatment-Resistant Depression (TRD)? [PDF]

Pharmaceuticals
Background/Objectives: Approximately one in five individuals will experience major depressive disorder (MDD), and 30% exhibit resistance to standard antidepressant treatments, resulting in a diagnosis of treatment-resistant depression (TRD). Historically,
Shaul Schreiber, Lee Keidan, Chaim G. Pick   +2 more
doaj   +2 more sources

Prescription Drugs in Pregnancy and Congenital Malformations: A Population‐Based Safety Screening Study [PDF]

Pharmacoepidemiology and Drug Safety, Volume 34, Issue 9, September 2025.
ABSTRACT Background Counseling women who are either pregnant or contemplating pregnancy on their use of prescribed drugs remains a major clinical challenge. Since the thalidomide tragedy in the 1960s, the use of drugs during pregnancy has been subject to widespread concern due to the potential for unwanted effects on the unborn child, notably major ...
Anne Broe, Anton Pottegård, Trine Munk‐Olsen, Jesper Hallas, Mette Bliddal, Irene Petersen, Per Damkier   +6 more
wiley   +2 more sources

Long‐Term Use of Benzodiazepines and Related Drugs in Persons With Major Depressive Disorder [PDF]

Brain and Behavior, Volume 15, Issue 11, November 2025.
ABSTRACT Introduction Benzodiazepines and related drugs (BZDRs) may be prescribed to treat anxiety and insomnia in persons with depression. Although BZDRs are recommended for short‐term use only, their use may be prolonged. Despite research on the use of BZDRs in depression, to our knowledge, long‐term use and its predictors have not been previously ...
Heli Laitinen, Miia Tiihonen, Antti Tanskanen, Jari Tiihonen, Johannes Lieslehto, Marjaana Koponen, Heidi Taipale   +6 more
wiley   +2 more sources

Validation in Drosophila of the in silico predicted clomipramine as repurposable for SOD1-ALS [PDF]

Neurotherapeutics
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by progressive motor neuron degeneration and muscle weakness, generally leading to death due to respiratory failure within 2–5 years of symptom onset.
Francesco Liguori, Susanna Amadio, Chiara Angioli, Angelo Ferriero, Iolanda Passaro, Francesca Alberti, Fiammetta Vernì, Cinzia Volonté   +7 more
doaj   +2 more sources

Evaluation of Methods Adjusting for Unmeasured Confounding Using Large Healthcare Databases: An Empirical Study Concerning Drugs Inducing Prematurity [PDF]

Clinical and Translational Science, Volume 18, Issue 11, November 2025.
ABSTRACT With the growing availability of large healthcare databases for clinical science, mitigating unmeasured confounding has emerged as a major issue in pharmacoepidemiologic studies. Extensions of causal inference methods to high‐dimensional settings could help address this problem, but studies comparing their performance in real‐world databases ...
Chi‐Hong Duong, Sylvie Escolano, Romain Demailly, Anne Thiebaut, Jonathan Cottenet, Catherine Quantin, Pascale Tubert‐Bitter, Ismaïl Ahmed   +7 more
wiley   +2 more sources

Antidepressants Use Among Pregnant Women in Denmark From 2001 to 2023: A Population‐Level Drug Utilization Study [PDF]

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 4, October 2025.
ABSTRACT We evaluated trends in antidepressant use among pregnant women in Denmark from 2001 to 2023, comparing them with a matched comparison group from the general population. Data from the Danish Health Data Authority were used to assess annual antidepressant prescription redemption rates per 1000 pregnancies, with a focus on total antidepressant ...
Anne‐Johanne Andersen, Kasper Nørlund Enevoldsen, Anne Sophie Enevoldsen, Erika B. Gram, Per Damkier   +4 more
wiley   +2 more sources

Utilization of psychotropic drugs in Serbia from 2006 to 2021: Patterns before and during the COVID-19 pandemic. [PDF]

PLoS ONE
BackgroundThe increasing global prevalence of mental disorders as well as a persistent stigma make mental disorders a public health priority. The aim of this study was to provide a comprehensive overview of psychotropic drugs utilization from 2006 to ...
Jelena Filimonovic, Milena Stevanovic, Tatjana Gazibara, Vladan Saponjic, Jelena Dotlic, Perisa Simonovic, Ivana Vukajlovic, Mirjana Stojanovic Tasic, Bojan Joksimovic, Maja Stosic, Miljan Adamovic, Marina Jelic, Jelena Perovic, Danijela Nastic Simovic, Ana Adamovic, Anastasija Karapandzic, Dajana Nogo Zivanovic, Zorica Stanojevic Ristic, Marija Milic   +18 more
doaj   +2 more sources

High-performance liquid chromatography–tandem mass spectrometry for simultaneous determination of 23 antidepressants and active metabolites in human serum and its application in therapeutic drug monitoring [PDF]

Frontiers in Pharmacology
IntroductionThe incidence and mortality rate from depression are increasing year by year, and depression has become the main cause of global health loss and disability. Currently, the treatment of depression mainly relies on drug intervention.
Jinglong Wang, Junjie Wang, Chenxiao Zhang, Guofei Li   +3 more
doaj   +2 more sources