Results 61 to 70 of about 2,998 (132)

National Prescribing Trends and Cost Analysis of Antidepressants, Anxiolytics, and Hypnotics in England, 2010–2023

Human Psychopharmacology: Clinical and Experimental, Volume 40, Issue 5, September 2025.
ABSTRACT Introduction We describe prescribing of anxiolytics/hypnotics/antidepressants at an all‐England level between 2010 and 2023, taking account of the influence of the COVID‐19 pandemic‐period. Methods All Primary Care Prescribing data for England for anxiolytics/hypnotics/antidepressant agents taken as tablets or capsules from 1 January 2010 to ...
Mike Stedman, Mark Davies, John Warner‐ Levy, Joseph Ingram, David Taylor, Adrian Heald   +5 more
wiley   +1 more source

Toxicological analyses of the bone matrix: Successes and challenges

Archaeometry, Volume 67, Issue 4, Page 1001-1021, August 2025.
Abstract This study aimed to conduct an in‐depth and systematic literature review dealing with toxicological analyses on human bone tissue and focusing on the forensic toxicological and archaeotoxicological field. Several studies have focused their research on medical drugs, drugs of abuse, and trace elements on both human cadavers and skeletal remains,
Gaia Giordano, Lucie Biehler‐Gomez, Cristina Cattaneo, Domenico Di Candia   +3 more
wiley   +1 more source

Inhibition of G protein-activated inwardly rectifying K+ channels by different classes of antidepressants. [PDF]

PLoS ONE, 2011
Various antidepressants are commonly used for the treatment of depression and several other neuropsychiatric disorders. In addition to their primary effects on serotonergic or noradrenergic neurotransmitter systems, antidepressants have been shown to ...
Toru Kobayashi, Kazuo Washiyama, Kazutaka Ikeda   +2 more
doaj   +1 more source

Serotonin Receptors in Areas of the Emotion Regulation Network in Human and Rat Brains—A Comparative Autoradiographic Study

Journal of Comparative Neurology, Volume 533, Issue 7, July 2025.
Serotonin receptors in areas of the emotion regulation network in human and rat brains a comparative autoradiographic study. Our systematic comparative analysis revealed significant differences of 5‐HT1A and 5‐HT2 receptor distributions and of their balance within and across components of the human emotion regulation network and homolog areas in rats ...
Anika Kuckertz, Ling Zhao, Olga Kedo, Katrin Amunts, Nicola PalomeroGallagher   +4 more
wiley   +1 more source

The Interplay of Cross‐Organ Immune Regulation in Inflammation and Cancer

MedComm, Volume 6, Issue 7, July 2025.
Organs interact dynamically through immune regulation, influencing systemic immune responses and disease progression. We review molecular and cellular mechanisms of cross‐organ immune regulation in inflammation and cancer, focusing on gut, liver, and brain interactions with other organs.
Jie Dou, Jinzuo Jiang, Yangtao Xue, Xiaoqi Jiang, Yongzhuo Jiang, Peng Xiao, Junjie Xu   +6 more
wiley   +1 more source

AI‐Driven Identification of Exceptionally Efficacious Polypharmacological Compounds That Extend the Lifespan of Caenorhabditis elegans

Aging Cell, Volume 24, Issue 7, July 2025.
A retrospective analysis of the most effective known geroprotectors shows that they act by polypharmacological mechanisms. Using graph neural networks, we predict polypharmacological geroprotectors, validate their polypharmacological mechanisms experimentally, and show them to be exceptionally effective.
Konstantin Avchaciov, Khalyd J. Clay, Kirill A. Denisov, Olga Burmistrova, Michael Petrascheck, Peter O. Fedichev   +5 more
wiley   +1 more source

Permanent relief from intermittent cold stress-induced fibromyalgia-like abnormal pain by repeated intrathecal administration of antidepressants

Molecular Pain, 2011
Background Fibromyalgia (FM) is characterized by chronic widespread pain, which is often refractory to conventional painkillers. Numerous clinical studies have demonstrated that antidepressants are effective in treating FM pain. We previously established
Mukae Takehiro, Araki Kohei, Nagai Jun, Uchida Hitoshi, Nishiyori Michiko, Kishioka Shiroh, Ueda Hiroshi   +6 more
doaj   +1 more source

Assessing the prevalence of anticholinergic and sedative medications to avoid in older adults from the French Health Data System

Journal of the American Geriatrics Society, Volume 73, Issue 5, Page 1542-1550, May 2025.
Abstract Background In older people, medications with anticholinergic or sedative properties are associated with falls, frailty, and functional and cognitive impairment. These medications are often described as a subset of potentially inappropriate medications (PIMs).
Teddy Novais, Antoine Garnier‐Crussard, Elsa Reallon, Christelle Mouchoux, Frederic Gervais   +4 more
wiley   +1 more source

The relative toxicity of medicines detected after poisoning suicide deaths in Australia, 2013–19: a data linkage case series study

Medical Journal of Australia, Volume 222, Issue 7, Page 339-347, April 2025.
Abstract Objective To compare the toxicity (relative to population use) and lethality (relative to poisoning events) of medicines involved in poisoning suicides in Australia; to determine the proportions of cases in which the medicines had recently been dispensed to the deceased person.
Jessy Lim, Nicholas A Buckley, Kate Chitty, Andrea L Schaffer, Jennifer Schumann, Zein Ali, Rose Cairns   +6 more
wiley   +1 more source

Deciphering the function of octopaminergic signaling on wing polyphenism of the pea aphid Acyrthosiphon pisum

Frontiers in Physiology, 2016
Aphids exhibit wing polyphenism (winged or wingless) for adaption to predictable or temporally heterogeneous environmental changes; however, the underlying mechanism is still unclear.
Xing-Xing Wang, Yi Zhang, Zhan-Feng Zhang, Hong-gang Tian, Tong-Xian Liu   +4 more
doaj   +1 more source