Results 61 to 70 of about 4,097 (189)
Antidepressant Adverse Reactions in Adult and Older Adult Populations: A Comparative Study From the Portuguese Pharmacovigilance System (2010–2020)
Journal of Clinical Pharmacy and Therapeutics, Volume 2026, Issue 1, 2026.Background
The use of antidepressants in Portugal has been increasing, raising concerns about their potential to cause adverse drug reactions (ADRs), particularly in vulnerable populations. This study aimed to characterize all ADRs associated with antidepressant use reported between January 1, 2010, and December 31, 2020, and to compare these findings ...Ana Catarina Coelho, Cristina Monteiro, Maria Vaz Patto, Anjali Chauhan +3 morewiley +1 more sourceChronic imipramine, L-sulpiride and mianserin decrease Corticotropin releasing Factor levels in the rat brain
, 1995 Among clinically effective antidepressant drugs, the action mechanism of mianserin has recently been related to variations in corticotropin releasing factor (CRF) levels in the rat locus coeruleus.Pani L., Fratta W., Anna Porcella, Walter Fratta, PANI L, Luca Pani, PORCELLA A, Fadda P., FADDA, PAOLA, FRATTA, WALTER, Porcella A., Paola Fadda +11 morecore +1 more sourceThe Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors
British Journal of Pharmacology, Volume 182, Issue S1, Page S24-S151, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,Stephen P. H. Alexander, Anthony P. Davenport, Eamonn Kelly, Alasdair J. Gibb, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Maria Pia Abbracchio, George R. Abraham, Alexander Agoulnik, Wayne Alexander, Khaled Al‐hosaini, Magnus Bäck, Jillian G. Baker, Nicholas M. Barnes, Ross Bathgate, Jean‐Martin Beaulieu, Annette G. Beck‐Sickinger, Maik Behrens, Kirstie A. Bennett, Kenneth E. Bernstein, Bernhard Bettler, Nigel J. M. Birdsall, Victoria A. Blaho, Pascal Bonaventure, Francois Boulay, Corinne Bousquet, Hans Bräuner‐Osborne, Andrew J. Brown, Geoffrey Burnstock, Marta Busnelli, Girolamo Caló, Vanni Caruso, Justo P. Castaño, Kevin J. Catt, Stefania Ceruti, Paul Chazot, Nan Chiang, Bice Chini, Arthur Christopoulos, Jerold Chun, Antonia Cianciulli, Olivier Civelli, Lucie H. Clapp, Réjean Couture, Helen M. Cox, Zsolt Csaba, Claes Dahlgren, Frank M. Dautzenberg, Gordon Dent, Steven D. Douglas, Pascal Dournaud, Margarita L. Dubocovich, Satoru Eguchi, Emanuel Escher, Edward J. Filardo, Tung Fong, Huamei Fu Forsman, Marta Fumagalli, Raul R. Gainetdinov, Michael L. Garelja, Marc de Gasparo, Florence Gbahou, Craig Gerard, Marvin Gershengorn, Michelle Glass, David E. Gloriam, Fernand Gobeil, Theodore L. Goodfriend, Cyril Goudet, Lukas Grätz, Karen J. Gregory, Christian Gruber, Andrew L. Gundlach, Jörg Hamann, Julien Hanson, Deborah S. Hartman, Richard L. Hauger, Debbie L. Hay, Akos Heinemann, Laura Heitman, Deron R. Herr, Morley D. Hollenberg, Nicholas D. Holliday, Birgitte Holst, Mastgugu Horiuchi, Daniel Hoyer, László Hunyady, Ahsan Husain, Adriaan P. IJzerman, Tadashi Inagami, Paul A. Insel, Kenneth A. Jacobson, Laura H. Jacobson, Robert T. Jensen, Ralf Jockers, Deepa Jonnalagadda, Sadashiva Karnik, Klemens Kaupmann, Jacqueline Kemp, Charles Kennedy, Yasuyuki Kihara, Julia Kinsolving, Takio Kitazawa, Pawel Kozielewicz, Hans‐Jürgen Kreienkamp, Jyrki P. Kukkonen, Luxmichan Laishram, Tobias Langenhan, Christopher J. Langmead, Dan Larhammar, Katie Leach, Davide Lecca, John D. Lee, Susan E. Leeman, Jérôme Leprince, Rob Leurs, Xaria X. Li, Ines Liebscher, Stephen J. Lolait, Amelie Lupp, Robyn Macrae, Janet J. Maguire, Davide Malfacini, Maurice Manning, Davide Marangon, Kirill Martemyanov, Jean Mazella, Craig A. McArdle, Shlomo Melmed, Martin C. Michel, Laurence J. Miller, Vincenzo Mitolo, Bernard Mouillac, Christa E. Müller, Philip M. Murphy, Jean‐Louis Nahon, Richard R. Neubig, Tony Ngo, Xavier Norel, Duuamene Nyimanu, Anne‐Marie O’Carroll, Stefan Offermanns, Maria Antonietta Panaro, Marc Parmentier, Nicole Perry‐Hauser, Roger G. Pertwee, Jean‐Philippe Pin, Eric R. Prossnitz, Helena Chengxue Qin, Mark Quinn, Stefano Raffaele, Rithwik Ramachandran, Manisha Ray, Rainer K. Reinscheid, Alejandro Romeral Buzón, Philippe Rondard, Mette M. Rosenkilde, G. Enrico Rovati, Chiara Ruzza, Gareth J. Sanger, Nicole Scholz, Torsten Schöneberg, Gunnar Schulte, Stefan Schulz, Deborah L. Segaloff, Charles N. Serhan, Arun K. Shukla, Khuraijam Dhanachandra Singh, Craig M. Smith, Nicola J. Smith, Claudia Stäubert, Leigh A. Stoddart, Yukihiko Sugimoto, Roger Summers, Valerie P. Tan, David M. Thal, Walter ( Wally) Thomas, Pieter B. M. W. M. Timmermans, Kalyan Tirupula, Lawrence Toll, Giovanni Tulipano, Hamiyet Unal, Thomas Unger, Celine Valant, Patrick Vanderheyden, David Vaudry, Hubert Vaudry, Joseph G. Verbalis, Jean‐Pierre Vilardaga, Christopher S. Walker, Ji Ming Wang, Donald T. Ward, Hans‐Jürgen Wester, Gary B. Willars, Tom Lloyd Williams, Trent M. Woodruff, Huixian Wu, Cheng Yang, Chengcan Yao, Richard D. Ye, Nathan Zaidman +206 morewiley +1 more sourceDelphi Consensus Among French Obesity Experts on Clinical Recommendations for Drug Prescription in Patients With Severe Obesity
Obesity Reviews, Volume 26, Issue 12, December 2025.ABSTRACT Introduction
Although the physiologic alterations seen in obesity often affect the pharmacokinetics and pharmacodynamics of drugs, most clinical trials do not consider these aspects specifically for this population. To date, there is no list of potentially inappropriate medications for patients living with obesity. The aim of this study was to Sarah Berdot, Germain Perrin, Emmanuel Disse, Armelle Arnoux, Eric Bertin, Anne‐Laure Borel, Marie‐Claude Brindisi, Arnaud De Luca, Edouard‐Jules Laforgue, Jean‐Daniel Lalau, Yann Matussiere, Emilie Montastier, Agnès Sallé, Bérénice Segrestin, Valentine Suteau, French Hospital Expert Panel, Sebastien Czernichow, Brigitte Sabatier +17 morewiley +1 more sourceSuppression of transcriptional drift extends C. elegans lifespan by postponing the onset of mortality
eLife, 2015 Longevity mechanisms increase lifespan by counteracting the effects of aging. However, whether longevity mechanisms counteract the effects of aging continually throughout life, or whether they act during specific periods of life, preventing changes that ...Sunitha Rangaraju, Gregory M Solis, Ryan C Thompson, Rafael L Gomez-Amaro, Leo Kurian, Sandra E Encalada, Alexander B Niculescu III, Daniel R Salomon, Michael Petrascheck +8 moredoaj +1 more sourceLong‐Term Use of Benzodiazepines and Related Drugs in Persons With Major Depressive Disorder
Brain and Behavior, Volume 15, Issue 11, November 2025.ABSTRACT Introduction
Benzodiazepines and related drugs (BZDRs) may be prescribed to treat anxiety and insomnia in persons with depression. Although BZDRs are recommended for short‐term use only, their use may be prolonged. Despite research on the use of BZDRs in depression, to our knowledge, long‐term use and its predictors have not been previously ...Heli Laitinen, Miia Tiihonen, Antti Tanskanen, Jari Tiihonen, Johannes Lieslehto, Marjaana Koponen, Heidi Taipale +6 morewiley +1 more sourceEvaluation of Methods Adjusting for Unmeasured Confounding Using Large Healthcare Databases: An Empirical Study Concerning Drugs Inducing Prematurity
Clinical and Translational Science, Volume 18, Issue 11, November 2025.ABSTRACT
With the growing availability of large healthcare databases for clinical science, mitigating unmeasured confounding has emerged as a major issue in pharmacoepidemiologic studies. Extensions of causal inference methods to high‐dimensional settings could help address this problem, but studies comparing their performance in real‐world databases ...Chi‐Hong Duong, Sylvie Escolano, Romain Demailly, Anne Thiebaut, Jonathan Cottenet, Catherine Quantin, Pascale Tubert‐Bitter, Ismaïl Ahmed +7 morewiley +1 more sourceLithium Augmentation in Treatment‐Resistant Depression: A Qualitative Review of the Literature
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 45, Issue 10, Page 688-701, October 2025.ABSTRACT
Depression is the leading cause of disability worldwide, affecting people of all ages. Both pharmacological and non‐pharmacological therapies are available for its treatment. However, some patients do not respond to first‐line pharmacological interventions, referred to as treatment‐resistant depression (TRD).Angela Acero‐González, Yahira Guzman, Nadia Juliana Proaños, Rosa‐Helena Bustos, María Aconcha, Ivan Guerrero, Laura Alejandra Martinez, Michael Berk, Seetal Dodd +8 morewiley +1 more sourceThe Effect of ABCB1 Polymorphisms on the Efficacy of Antidepressants
Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 4, October 2025.ABSTRACT
This scoping review investigates the association between ABCB1 polymorphisms and antidepressant efficacy in humans. A systematic search identified 630 records, of which 58 met the inclusion criteria, resulting in 42 unique studies (five randomised controlled trials (RCTs), two randomised studies (non‐RCTs), 30 prospective cohort studies, three Sofie Voss Thorsen, Cille Bülow, Kim Dalhoff, David Peick Sonne +3 morewiley +1 more source
