Results 161 to 170 of about 38,276 (260)

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, EarlyView.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

Alpha-Fetoprotein Stimulates Cleavage of Membranal MICA/B on Liver Cancer Cell Lead to Escape Immune Surveillance of Natural Killer Cells. [PDF]

J Cell Mol Med
Li X, Feng S, Wu X, Pan Y, Zhou Y, Liu K, Lin B, Li W, Li M, Zhu M.   +9 more
europepmc   +1 more source

tRNA‐Derived Small RNAs in Digestive Cancers: From Translational Regulation to Immune and Extracellular Communication

Cancer Science, EarlyView.
tRNA‐derived small RNAs (tsRNAs) function in digestive cancers across three scales: intracellular translational and metabolic control, extracellular vesicle–mediated immune remodeling, and systemic and host–microbe communication. This review organizes these mechanisms by evidence strength, from well‐established intracellular roles to emerging ...
Wang Xitan, Li Han
wiley   +1 more source

Targeting SLC5A2 suppresses colorectal tumour development by enhancing NK cell activity through extracellular vesicle-dependent MICA/B signalling. [PDF]

Clin Transl Med
Xiao J, Wu J, Deng F, Liu C, Chen Y, Shen K, Wang C, Lin W, Liu W, Ning Z, Zhou R, Zhao L.   +11 more
europepmc   +1 more source

Integrated Engineering of CAR‐T Cells for Solid Tumours

Cell Proliferation, EarlyView.
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang, Tan Li, Ping He, Zhijie Zhao, Shenglong Li, Liming Wang   +5 more
wiley   +1 more source

A fully human IgG1 antibody targeting MICA α1 domain inhibits interaction with NKG2D and activates immune effector functions against MICA-expressing cells. [PDF]

Front Immunol
Campos I, González-Herrera F, Guerra Y, Garrido MJ, Fehring N, Diaz C, Matthies DJ, González M, Tello S, Tempio F, Vásquez G, Rodríguez-Siza J, Gutiérrez M, Leiva L, Romero A, Collazo N, Zúñiga R, Valck C, Ribeiro CH, Altamirano C, Toledo-Stuardo K, Molina MC.   +21 more
europepmc   +1 more source

Understanding and addressing resistance to IMiDs immunomodulatory compounds in multiple myeloma

The FEBS Journal, EarlyView.
IMiDs are pivotal in the treatment of multiple myeloma. Mechanisms of resistance comprise cell intrinsic and extrinsic pathways, involving tumour microenvironment, immune cell dysfunction, CRBN‐dependent and independent genetic drivers and epigenetic changes.
Maria‐Cynthia Fuentes‐Lacouture, Devi Nandana, Karthik Ramasamy, Anjan Thakurta   +3 more
wiley   +1 more source

Measuring Extended Water Interfacial Structures. Water Nanoclusters (∼50 nm) Involved by Ice-like II Walls (∼10 nm). [PDF]

Langmuir
Teschke O, Gomes WE, Casagrande PS, deCastro JR, Soares DM.   +4 more
europepmc   +1 more source

Influence of Polymer and Rubber Modification on Fatigue Crack Propagation in Asphalt Mixtures: A Cyclic SCB and Paris Law Investigation

Fatigue &Fracture of Engineering Materials &Structures, EarlyView.
ABSTRACT Fatigue cracking is a major distress limiting asphalt pavement service life, and Paris law–based fracture mechanics offers a more mechanistic understanding than conventional fatigue testing. However, systematic characterization across diverse modifiers, dosages, notch depths, and temperatures remains limited.
Abdullah Demirbag, Erkut Yalcin, Ragip Ince, Mehmet Yilmaz   +3 more
wiley   +1 more source

Water doping sodium battery electrolyte controls nanostructure, interactions, and electrochemical properties. [PDF]

Sci Adv
Zhang X, Zheng Q, Li H, Goodwin ZAH, Hoane AG, Deptula A, Johnson OM, Song J, Markiewitz DM, Bazant MZ, Leal C, Mangolini F, Gewirth AA, Atkin R, Rutland MW, Espinosa-Marzal RM.   +15 more
europepmc   +1 more source