Results 61 to 70 of about 9,080 (185)

Foxn1 Control of Skin Function

Applied Sciences, 2020
The forkhead box N1 (Foxn1) transcription factor regulates biological processes of the thymus and skin. Loss-of-function mutations in Foxn1 cause the nude phenotype in humans, mice, and rats, which is characterized by hairless skin and a lack of thymus ...
Barbara Gawronska-Kozak
doaj   +1 more source

Mechanistic investigation of Liujing Toutong tablet in the treatment of cerebral ischemia–reperfusion injury in rats by the integration of serum pharmacochemistry and metabolomics

Animal Models and Experimental Medicine, Volume 9, Issue 6, Page 1105-1125, June 2026.
The research strategy for pharmacodynamics, serum pharmacochemistry, metabolomics, and network pharmacology analysis method in intervention effects of LTT are illustrated. Abstract Background Liujing Toutong tablet (LTT) is a traditional Chinese patent medicine.
Zihan Yu, Ke Pei, Xiulin Wang, Wenling Li, Hongchang Li, Wangyang Xie, Xianglong Meng, Tingting Zhao, Yan Ning, Haixin Liu, Wenbin He   +10 more
wiley   +1 more source

Acid ceramidase overactivity drives ceramide loss, leading to atopic dry skin and Th2‐skewed immune polarization

The Journal of Pathology, Volume 269, Issue 2, Page 232-247, June 2026.
Abstract Ceramide deficiency in the stratum corneum (SC) is a key etiological factor in atopic dermatitis (AD). To clarify the direct role of SC ceramide depletion in impairing SC barrier and water‐holding functions and in initiating AD‐like skin symptoms and disease‐specific molecular alterations, we generated Tg mice overexpressing a mutant form of ...
Mariko Takada, Miho Sashikawa‐Kimura, Yusuke Ohno, Md Razib Hossain, Xiaonan Xie, Kazuhisa Iwabuchi, Mayumi Komine, Mamitaro Ohtsuki, Genji Imokawa   +8 more
wiley   +1 more source

Shrubs and trees as natural insect protection for grazing animals in Switzerland and the alpine region: A systematic review of in vitro, in vivo and clinical trials Sträucher und Bäume als natürlicher Insektenschutz für Weidetiere in der Schweiz und im Alpenraum: Eine systematische Literaturübersicht über in vitro‐, in vivo‐ und klinische Studien

Medical and Veterinary Entomology, Volume 40, Issue 2, Page 221-245, June 2026.
Biting or irritating insects are a threat to the health and welfare of grazing animals. This systematic review reveals that several shrubs and bushes growing in the alpine area have insecticidal, insect‐repellent and/or attractant properties. The alder Alnus glutinosa, juniper Juniperus communis, spruce Picea abies and walnut Juglans regia are ...
Theresa Schlittenlacher, Sofie Egli, Michael Walkenhorst, Veronika Maurer   +3 more
wiley   +1 more source

Protective effects of gallocatechin gallate against ultraviolet B induced skin damages in hairless mice

Scientific Reports, 2022
Epigallocatechin gallate (EGCG) has the effect to protect skin from ultraviolet B (UVB) induced damages, but it is unstable under ambient conditions, being susceptible to become brown in color.
Yue-Yue Sheng, Jing Xiang, Jian-Liang Lu, Jian-Hui Ye, Zi-Jiu Chen, Jian-Wen Zhao, Yue-Rong Liang, Xin-Qiang Zheng   +7 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, Volume 20, Issue 5, Page 1220-1236, May 2026.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Effects of Ozone‐Depleting Substances on Ultraviolet Radiation and Skin Cancer Rates in Australia and the United States of America

GeoHealth, Volume 10, Issue 5, May 2026.
Abstract Stratospheric ozone (O3) losses and consequent increases in surface ultraviolet (UV) radiation remain a health concern due to close association with skin cancers and cataracts. This study estimated how emissions of ozone‐depleting substances (ODS) affect, via O3 reductions, surface UV radiation and associated health impacts in Australia ...
Julia Lee‐Taylor, Zeyu Hu, Jessica Kyle, Ken Karipidis, Stuart Henderson, Robert Landolfi, Christopher M. Tasich, Sasha Madronich   +7 more
wiley   +1 more source

The hairless (hr) gene is involved in the congenital hypotrichosis of Valle del Belice sheep

Genetics Selection Evolution, 2003
Congenital hypotrichosis in mammalian species consists of partial or complete absence of hair at birth. The hairless gene is often responsible for this disorder in men, mice and rats.
Finocchiaro Raffaella, Portolano Baldassare, Damiani Giuseppe, Caroli Anna, Budelli Elena, Bolla Patrizia, Pagnacco Giulio   +6 more
doaj   +1 more source

Far-infrared suppresses skin photoaging in ultraviolet B-exposed fibroblasts and hairless mice. [PDF]

PLoS ONE, 2017
Ultraviolet (UV) induces skin photoaging, which is characterized by thickening, wrinkling, pigmentation, and dryness. Collagen, which is one of the main building blocks of human skin, is regulated by collagen synthesis and collagen breakdown.
Hui-Wen Chiu, Cheng-Hsien Chen, Yi-Jie Chen, Yung-Ho Hsu   +3 more
doaj   +1 more source

Bruton tyrosine kinase (Btk) in neutrophils is indispensable for initiating and maintaining skin inflammation in a model of pemphigoid diseases

British Journal of Pharmacology, Volume 183, Issue 10, Page 2446-2463, May 2026.
Background and Purpose Bruton tyrosine kinase (Btk) is essential for B cell function. Its role in myeloid cells is less understood. Greater insights into Btk significance in myeloid cells are needed to evaluate its potential as a therapeutic target during the effector phase of antibody‐induced autoimmune diseases, where inhibiting autoantibody ...
Henning Olbrich, Paul Schilf, Sripriya Murthy, Sina Gonther, Mareike Neumann, Christoph M. Hammers, Jasper N. Pruessmann, Christian D. Sadik   +7 more
wiley   +1 more source