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A multiomic network approach uncovers disease modifying mechanisms of inborn errors of metabolism
Bender A+11 more
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Genetic control of hepatocarcinogenesis in C57BL/6J and C3H/HeJ inbred mice.
Carcinogenesis, 1986Treatment of newborn male C3H/HeJ mice with N,N-diethyl-nitrosamine (DEN) or N-ethyl-N-nitrosourea (ENU) resulted in the induction of hepatocellular adenomas and carcinomas with a mean number of tumors per animal that was approximately 20- to 50-fold ...
N. Drinkwater, J. Ginsler
semanticscholar +4 more sources
Alcoholism: Clinical and Experimental Research, 1989
Sensitivity to alcohol may influence the severity of ethanol teratogenesis. To examine this hypothesis, the teratogenic effects of ethanol were compared in Long-Sleep (LS) and Short-Sleep (SS) mice, selectively bred for differences in ethanol-induced ...
D. Gilliam, L. Kotch, B. Dudek, E. Riley
semanticscholar +3 more sources
Sensitivity to alcohol may influence the severity of ethanol teratogenesis. To examine this hypothesis, the teratogenic effects of ethanol were compared in Long-Sleep (LS) and Short-Sleep (SS) mice, selectively bred for differences in ethanol-induced ...
D. Gilliam, L. Kotch, B. Dudek, E. Riley
semanticscholar +3 more sources
Behavior Genetics, 1994
Exploratory behaviors as well as pharmacological actions of gamma-aminobutyric acidA (GABAA)/benzodiazepine receptor agonists and inverse agonists were characterized in C57BL/6J and A/J strains of mice. C57BL/6J mice displayed higher levels of exploratory behavior than A/J mice in the light in equilibrium with dark exploration model of anxiety and in ...
C. Mathis, S. Paul, J. Crawley
semanticscholar +4 more sources
Exploratory behaviors as well as pharmacological actions of gamma-aminobutyric acidA (GABAA)/benzodiazepine receptor agonists and inverse agonists were characterized in C57BL/6J and A/J strains of mice. C57BL/6J mice displayed higher levels of exploratory behavior than A/J mice in the light in equilibrium with dark exploration model of anxiety and in ...
C. Mathis, S. Paul, J. Crawley
semanticscholar +4 more sources
Quantitative trait loci for bone density in C57BL/6J and CAST/EiJ inbred mice [PDF]
Genetic analyses for loci regulating bone mineral density have been conducted in a cohort of F(2) mice derived from intercross matings of (C57BL/6J x CAST/EiJ)F(1) parents. Femurs were isolated from 714 4-month-old females when peak adult bone density had been achieved.
W. Beamer+6 more
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Behavioral sensitization to drug stimulant effects in C57BL/6J and DBA/2J inbred mice.
Behavioral Neuroscience, 1994Common features shared by addictive drugs have been difficult to identify. One ubiquitous effect of these drugs is psychomotor stimulation. Further, repeated exposure commonly results in sensitization to drug stimulant effects.
Tamara J. Phillips+2 more
semanticscholar +4 more sources
Behavior genetics, 1998
The role of genotype in susceptibility to the behavioral actions of benzodiazepines is not well characterized. To develop a model for such studies, we have characterized the anxiolytic and sedative activities of diazepam in C57BL/6J and A/J inbred mice. C57BL/6J mice were more responsive than A/J mice to diazepam-induced anxiolytic-like activity in the
K. Garrett+4 more
semanticscholar +4 more sources
The role of genotype in susceptibility to the behavioral actions of benzodiazepines is not well characterized. To develop a model for such studies, we have characterized the anxiolytic and sedative activities of diazepam in C57BL/6J and A/J inbred mice. C57BL/6J mice were more responsive than A/J mice to diazepam-induced anxiolytic-like activity in the
K. Garrett+4 more
semanticscholar +4 more sources
Identification of vacuolar autophagic aggregates in the skeletal muscles of inbred C57BL/6NCrl mice
Laboratory Animals, 2023A comprehensive pathological analysis of inbred strains is essential to define strain-specific spontaneous lesions and to understand whether a specific phenotype results from experimental intervention or reflects a naturally occurring disease. This study aimed to report and describe a novel condition affecting the skeletal muscles of an inbred C57BL ...
De Biase D.+10 more
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Maternal Behavior in Female C57BL/6J and DBA/2J Inbred Mice
Physiology & Behavior, 1999Inbred strains of mice exhibit different patterns of maternal behavior, providing material for studies of genetic influences on the expression of maternal behavior. Beginning 1 day after birth, maternal behavior was recorded daily for 14 days in the first and second litters of C57BL/6J (B6) and DBA/2J (D2) mothers.
Richard E. Brown+3 more
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