Results 91 to 100 of about 19,573 (206)
Glucose Homeostasis and Tissue Transcript Content of Insulin Signaling Intermediates in Four Inbred Strains of Mice: C57BL/6, C57BLKS/6, DBA/2, and 129X1 [PDF]
Endocrinology, 2004 Abstract Transgenic mice phenotypes generally depend on the background strains used in their creation. To examine the effects of genetic background on insulin signaling, we analyzed glucose homeostasis in four inbred strains of mice [C57BL/6 (B6), C57BLKS/6 (KLS), DBA/2 (DBA), and 129X1] and quantitated mRNA content of insulin receptor ...
H Joseph, Goren +2 more
openaire +2 more sources
Genes, Brain and Behavior, Volume 24, Issue 2, April 2025.Core symptoms of human DCD modeled in BXD recombinant inbred strains of mice. Significant strain differences for all measures of motor coordination were found. Three significant quantitative trait loci and seven candidate genes for gait were identified.
Jeffy Rajan Soundara Rajan +6 more
wiley +1 more source
Frontiers in Behavioral Neuroscience, 2014 Several behavioral interventions, based on social enrichment and observational learning are applied in treatment of neuropsychiatric disorders. However, the mechanism of such modulatory effect and the safety of applied methods on individuals involved in ...
Natalia eKulesskaya +4 more
doaj +1 more source
Behavioural characterization of C57BL/6N and BALB/c female mice in social home cage – Effect of mixed housing in complex environment [PDF]
, 2018 Developing reliable mouse models for social behaviour is challenging. Different tests have been proposed, but most of them consist of rather artificial confrontations of unfamiliar mice in novel arenas or are relying on social stress induced by ...
Heinla, Indrek +3 more
core +1 more source
To Tweak or Not to Tweak. How Exploiting Flexibilities in Gene Set Analysis Leads to Overoptimism
Biometrical Journal, Volume 67, Issue 1, February 2025.ABSTRACT Gene set analysis, a popular approach for analyzing high‐throughput gene expression data, aims to identify sets of genes that show enriched expression patterns between two conditions. In addition to the multitude of methods available for this task, users are typically left with many options when creating the required input and specifying the ...
Milena Wünsch +4 more
wiley +1 more source
Allele-specific expression and eQTL analysis in mouse adipose tissue. [PDF]
, 2014 BackgroundThe simplest definition of cis-eQTLs versus trans, refers to genetic variants that affect expression in an allele specific manner, with implications on underlying mechanism.
Drake, Thomas A +6 more
core +2 more sources
Addiction Biology, Volume 30, Issue 2, February 2025.The genetic basis for analgesic properties of alcohol was studied using the BXD panel of mice and identified multiple areas of the genome influencing alcohol analgesia. By combining this genetic mapping with bioinformatic analyses of existing pain literature, candidate genes were prioritized and identified Myo6 as a potential regulator of alcohol ...
Walker D. Rogers +3 more
wiley +1 more source
A phenotypic and molecular characterization of the fmr1-tm1Cgr Fragile X mouse [PDF]
, 2004 Fragile X Syndrome is the most common form of\ud inherited mental retardation. It is also known for having\ud a substantial behavioral morbidity, including autistic features. In humans, Fragile X Syndrome is almost always\ud caused by inactivation of the
Bauchwitz, Dr. Robert P.
core +1 more source
Discovery of Novel Pain Regulators Through Integration of Cross‐Species High‐Throughput Data
CNS Neuroscience &Therapeutics, Volume 31, Issue 2, February 2025.Cross‐species analysis was used to identify novel pain mediators based on human DRG expression profiles and RNA‐seq data from a mouse model of neuropathic pain injury. ABSTRACT Aims Chronic pain is an impeding condition that affects day‐to‐day life and poses a substantial economic burden, surpassing many other health conditions.
Ying Chen +9 more
wiley +1 more source
Does tolerance to ethanol-induced ataxia explain the sensitized response to ethanol?
Frontiers in PsychiatryUnder conditions of repeated exposure to ethanol, a sensitized locomotor stimulant response develops in some strains of mice. It has been hypothesized that the sensitized response is a consequence of tolerance development to the sedative/incoordinating ...
Cheryl Reed +4 more
doaj +1 more source