Results 161 to 170 of about 13,850 (186)

A major influence of sex-specific loci on alcohol preference in C57Bl/6 and DBA/2 inbred mice

Mammalian Genome, 1998
C57Bl/6 mice reproducibly prefer to ingest more 10% ethanol in a two-bottle choice paradigm than do DBA/2J mice. In this paper we report the identification of two new sex-specific alcohol preference (Alcp) loci. Melo and associates (1996) identified two loci: Alcp1, a male-specific locus on Chromosome (Chr) 2, and Alcp2, a female- and cross-specific ...
Lee M. Silver, Therese Kolata, Jeremy L. Peirce, Jay Shendure, Rachel Derr   +4 more
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Characterization of cortical spindles in DBA/2 and C57BL/6 inbred mice

Brain Research Bulletin, 1984
Continuous twenty-four hour EEG recordings were conducted on freely-moving DBA/2 and C57BL/6 inbred mice. No brief spindle episodes (BSEs: 6-7 cps, 1-5 sec duration, high amplitude spindle bursts) were seen in the waking EEG of C57BL/6 mice. BSEs were a conspicuous element of the EEG during active waking (AW) and quiet waking (QW) in DBA/2 mice.
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Locomotor stimulant effects of cocaine and novel cocaine analogs in DBA/2J and C57BL/6J inbred mice

Pharmacology Biochemistry and Behavior, 1995
The current study compared the potencies of cocaine and a series of substituted phenyltropane analogs of cocaine in stimulating locomotor activity in two genetically distinct strains of mice previously shown to differ in their locomotor responsiveness to cocaine.
Bryan K. Tolliver, John M. Carney
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Discriminative stimulus effects of 5.6mg/kg pregnanolone in DBA/2J and C57BL/6J inbred mice

Alcohol, 2005
Neurosteroids represent a class of endogenous compounds that exert rapid, nongenomic effects through neurotransmitter receptor systems such as gamma-aminobutyric acid(A) (GABA(A)). Two neurosteroids, allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one) and pregnanolone (3alpha-hydroxy-5beta-pregnan-20-one), possess anxiolytic and sedative properties
Kathleen A. Grant, Erin E. Shannon, Robert H. Purdy, Robert H. Purdy   +3 more
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A comparison of the discriminative stimulus properties of the atypical antipsychotic drug clozapine in DBA/2 and C57BL/6 inbred mice

Behavioural Pharmacology, 2008
Inbred mouse strain comparisons are an important aspect of pharmacogenetic research, especially in strains known to differ in regard to specific neurotransmitter systems. DBA/2 mice differ from C57BL/6 mice in terms of both functional and anatomical characteristics of dopamine systems.
Joseph H. Porter, Sarah A. Vunck, John C. Crabbe, David Matthew Walentiny, Scott D. Philibin   +4 more
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Opposite genotype-specific effects of serotoninergic treatments on Pavlovian Conditioned Approach in mice of two inbred strains C57 BL/6J and DBA/2J

Behavioural Pharmacology, 2021
Individual variability in the response to pharmacological therapies is a major problem in the treatment of psychiatric disorders. Comparative studies of phenotypes expressed by mice of the C57BL/6J (C57) and DBA/2J (DBA) inbred strains can help identify neurobiological determinants of this variability at preclinical levels.
Maiolati, Marzia, Tarmati, Valeria, Latagliata, Claudio, Cabib, Simona, Orsini, Cristina   +4 more
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Strain and sex differences on olfactory discrimination learning in C57BL/6J and DBA/2J inbred mice (Mus musculus).

Journal of Comparative Psychology, 2000
In this study, the authors explored potential strain and sex differences in nonspatial cognitive ability. Beginning around 90 days of age, male and female C57BL/6J (C57) and DBA/2J (DBA) inbred mice (Mus musculus) were tested on a task of simple odor discrimination learning with 3 repeated reversals.
Jason C. Langlois, Sheila M. Mihalick, Jason D. Krienke   +2 more
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Quantitative Trait Loci (QTL) analysis of longevity in C57BL/6J by DBA/2J (BXD) recombinant inbred mice

Aging Clinical and Experimental Research, 2010
Genes associated with longevity have been identified using both single gene and genome-wide approaches in a variety of species. The aim of this study was to identify quantitative trait loci (QTLs) that influence longevity in male and female mice from twenty-three C57BL/6J by DBA/2J (BXD) recombinant inbred (RI) strains.Approximately 12 animals of each ...
Gerald E. McClearn, David A. Blizard, Joseph T. Stout, James W. Griffith, David J. Vandenbergh, Glenn S. Gerhard, George P. Vogler, Dean H. Lang, Joan M. Lakoski   +8 more
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Susceptibility to conditioned place preference induced by addictive drugs in mice of the C57BL/6 and DBA/2 inbred strains

Psychopharmacology, 2005
In previous studies, we have demonstrated that mice of the inbred strain C57BL/6J (C57) are more susceptible to amphetamine-induced conditioned place preference (CPP) than DBA/2J (DBA) mice. Moreover, we also observed parallel strain differences for the locomotor-stimulant effects of the drug.
ORSINI, CRISTINA, BONITO OLIVA, ALESSANDRA, CONVERSI, DAVID, CABIB, Simona   +3 more
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Role of the anterior and posterior Paraventricular Nucleus of the Thalamus on Sign-Tracking in inbred C57BL/6J and DBA/2J mice

2022
Aims: Sign-tracking (ST) behavior is a model of overwhelming attraction to rewards-associated stimuli due to incentive salience attribution as measured by the Pavlovian Conditioned Approach (PCA) paradigm. Previous studies suggested different strain-specific neurobiological substrates underlying ST behavior.
Valeria Tarmati, Cristina Orsini, Simona Cabib   +2 more
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