Results 21 to 30 of about 2,093 (92)
OCH Ameliorates Bone Marrow Failure in Mice via Downregulation of T‐Bet Expression
Journal of Immunology Research, Volume 2014, Issue 1, 2014., 2014 The aim of this study is to evaluate the immune mechanism of OCH in the treatment of AA (also named bone marrow failure, BMF) induced in mice. OCH at a dose of 400 μg/kg was injected intraperitoneally (I.P.) prior to the induction of BMF. Our study showed that the incidence of BMF was 100% in BMF group and 13% in OCH treatment group. Significant higher
Xiaohong Qiao +6 more
wiley +1 more source
Role of MHC‐Linked Susceptibility Genes in the Pathogenesis of Human and Murine Lupus
Journal of Immunology Research, Volume 2012, Issue 1, 2012., 2012 Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies against nuclear antigens and a systemic inflammation that can damage a broad spectrum of organs. SLE patients suffer from a wide variety of symptoms, which can affect virtually almost any tissue.
Manfred Relle +2 more
wiley +1 more source
Murine Models of Systemic Lupus Erythematosus
BioMed Research International, Volume 2011, Issue 1, 2011., 2011 Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disorder. The study of diverse mouse models of lupus has provided clues to the etiology of SLE. Spontaneous mouse models of lupus have led to identification of numerous susceptibility loci from which several candidate genes have emerged.
Daniel Perry +5 more
wiley +1 more source
Current Concepts: Mouse Models of Sjögren′s Syndrome
BioMed Research International, Volume 2011, Issue 1, 2011., 2011 Sjögren′s syndrome (SjS) is a complex chronic autoimmune disease of unknown etiology which primarily targets the exocrine glands, resulting in eventual loss of secretory function. The disease can present as either primary SjS or secondary SjS, the latter of which occurs concomitantly with another autoimmune disease such as rheumatoid arthritis ...
Tegan N. Lavoie +3 more
wiley +1 more source
BioMed Research International, Volume 2011, Issue 1, 2011., 2011 Rodent models of immune‐mediated arthritis (RMIA) are the conventional approach to evaluating mechanisms of inflammatory joint disease and the comparative efficacy of antiarthritic agents. Rat adjuvant‐induced (AIA), collagen‐induced (CIA), and streptococcal cell wall‐induced (SCW) arthritides are preferred models of the joint pathology that occurs in ...
Brad Bolon +7 more
wiley +1 more source
Mass Spectrometry Reviews, Volume 44, Issue 3, Page 213-453, May/June 2025.Abstract The use of matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this review is the 12th update of the original article published in 1999 and brings coverage of the literature to the end of 2022.
David J. Harvey
wiley +1 more source
The Current Concept of TH17 Cells and Their Expanding Role in Systemic Lupus Erythematosus
Arthritis, Volume 2011, Issue 1, 2011., 2011 Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a multifaceted range of symptoms affecting almost every organ system. The prototypical pathology of SLE involves the production of antinuclear antibodies and the deposition of immune complexes in basement membranes throughout the body where they induce inflammatory responses.
Daniel Perry +5 more
wiley +1 more source
Signaling Activation and Modulation in Extrafollicular B Cell Responses
Immunological Reviews, Volume 330, Issue 1, March 2025.ABSTRACT The differentiation of naive follicular B cells into either the germinal center (GC) or extrafollicular (EF) pathway plays a critical role in shaping the type, affinity, and longevity of effector B cells. This choice also governs the selection and survival of autoreactive B cells, influencing their potential to enter the memory compartment ...
Julian Staniek, Marta Rizzi
wiley +1 more source
Cytokines and Cytokine Profiles in Human Autoimmune Diseases and Animal Models of Autoimmunity
Mediators of Inflammation, Volume 2009, Issue 1, 2009., 2009 The precise pathomechanisms of human autoimmune diseases are still poorly understood. However, a deepened understanding of these is urgently needed to improve disease prevention and early detection and guide more specific treatment approaches. In recent years, many new genes and signalling pathways involved in autoimmunity with often overlapping ...
Manfred Kunz +2 more
wiley +1 more source
A Novel Human Interleukin‐23A Overexpressing Mouse Model of Systemic Lupus Erythematosus
Arthritis &Rheumatology, Volume 76, Issue 7, Page 1085-1095, July 2024.Objective Interleukin‐23 (IL‐23) is a crucial cytokine implicated in chronic inflammation and autoimmunity, associated with various diseases such as psoriasis, psoriatic arthritis, and systemic lupus erythematosus (SLE). This study aimed to create and characterize a transgenic mouse model overexpressing human IL‐23A (TghIL‐23A), providing a valuable ...
Eleni Christodoulou‐Vafeiadou +6 more
wiley +1 more source