Results 151 to 160 of about 145,801 (250)
The Evolution of Locally Adaptive Chromosome Inversions in Mimulus guttatus
Molecular Ecology, EarlyView.ABSTRACT Chromosomal inversion polymorphisms are ubiquitous across the diversity of diploid organisms and play a significant role in the evolution of adaptations in those species. Inversions are thought to operate as supergenes by trapping adaptive alleles at multiple linked loci through the suppression of recombination. While there is now considerable
Leslie M. Kollar +4 more
wiley +1 more source
Immunomodulation of salivary gland function due to cancer therapy
Oral Diseases, EarlyView.Abstract Functional salivary glands (SG) are essential for maintaining oral health, and salivary dysfunction is a persistent major clinical challenge. Several cancer therapies also have off‐target effects leading to SG dysfunction. Recent advances highlight the role of SG immune populations in homeostasis, dysfunction and gland regeneration.
Ana C. Costa‐da‐Silva +3 more
wiley +1 more source
Plant Biotechnology Journal, EarlyView.Summary The CRISPR/Cas9 system is a powerful tool for genomic editing with significant potential for gene function validation and molecular breeding in medicinal plants. Salvia miltiorrhiza, a model medicinal plant, was among the pioneers to utilize CRISPR/Cas9 technology, though achieving high‐efficiency homozygous knockout mutants has been ...
Mei Tian +11 more
wiley +1 more source
Veterinary Clinical Pathology, EarlyView.Abstract MicroRNAs (miRNAs or miRs) are small, non‐coding RNAs that play a crucial role in gene regulation, making them potential biomarkers for various diseases. In the field of veterinary medicine, there is a growing interest in exploring the diagnostic and therapeutic potential of miRNAs in kidney diseases affecting dogs and cats.
Candice P. Chu, Mary B. Nabity
wiley +1 more source
In Silico Approaches and the Role of Ontologies in Aging Research [PDF]
, 2013 The 2013 Rostock Symposium on Systems Biology and Bioinformatics in Aging Research was again dedicated to dissecting the aging process using in silico means.
Busch, Hauke +14 more
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The Journal of Physiology, EarlyView.Abstract figure legend Both ATP synthase and adenine nucleotide translocator (ANT) play key roles in mediating the permeability transition. The contribution of ANT becomes evident in the presence of atractylate (ATR) at pH 6.5, a condition that prevents ATP synthase channel activity. At pH 7.4, this effect is minimal, suggesting a critical role for ATP
Ludovica Tommasin +7 more
wiley +1 more source
Mass Spectrometry Reviews, Volume 44, Issue 3, Page 213-453, May/June 2025.Abstract The use of matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this review is the 12th update of the original article published in 1999 and brings coverage of the literature to the end of 2022.
David J. Harvey
wiley +1 more source
Effects of Aging on Glucose and Lipid Metabolism in Mice
Aging Cell, Volume 24, Issue 4, April 2025.Lien et al. report a characterization of metabolism with aging across three different strains of mice. They find that glucose metabolism is robust during healthy aging; however, aging tissues exhibit evidence of upregulated fatty acid and sphingolipid metabolism reactions that regenerate NAD+ from NADH.
Evan C. Lien +8 more
wiley +1 more source
Genetic Loci Influencing Cue‐Reactivity in Heterogeneous Stock Rats
Genes, Brain and Behavior, Volume 24, Issue 2, April 2025.A genome‐wide association study characterizing individual differences in cue‐reactivity (sign‐tracking; A) identifies multiple genetic loci, particularly on chromosomes 1 and 18 (B). Multiple candidate genes in these regions were identified, including those with known psychiatric relevance (e.g., Tenm4; C) and novel candidates with heritable ...
Christopher P. King +23 more
wiley +1 more source
A novel mouse model of diverse tumors derived from epithelial cells
Physiological Reports, Volume 13, Issue 7, April 2025.CK19‐CreER/LSL‐KRasG12D/P53L/L/R26‐LSL‐LacZ mice could recapitulate multiple tumors originating from epithelial cells. Abstract A deeper understanding of pathophysiology, from the initiation of tumors of epithelial cells to the outcomes associated with it, is imperative to test potential interventions for these diseases.
Bin Wang +9 more
wiley +1 more source