Results 151 to 160 of about 259,574 (259)

The Impact of Brain‐Derived Neurotrophic Factor rs6265 (Val66Met) Polymorphism on Therapeutic Electrical Stimulation for Peripheral Nerve Regeneration: A Preclinical Study of Therapy–Genotype Interactions

Muscle &Nerve, Volume 72, Issue 1, Page 149-157, July 2025.
The rs6265 (Val66Met) BDNF SNP determines responsiveness to a clinically relevant therapeutic electrical stimulation (TES) protocol following peripheral nerve injury. This study examined gene–treatment interactions using a rat model of sciatic nerve injury and human iPSC‐derived motor neurons to assess how the common rs6265 BDNF polymorphism influences
Jordan B. Walters, Maria J. Quezada, Suning He, Ciara S. Haynes, Kathy Steece‐Collier, Timothy J. Collier, Caryl E. Sortwell, Colin K. Franz   +7 more
wiley   +1 more source

Aging‐Associated Vacuolation of Multi‐Ciliated Cells in the Distal Mouse Oviduct Reflects Unique Cell Identity and Luminal Microenvironment

Aging Cell, Volume 24, Issue 7, July 2025.
Multi‐ciliated cells in the infundibulum and ampulla (INF/AMP) epithelium are vacuolated in aging. Unique cellular susceptibility of the INF/AMP epithelial population and aging‐associated decline in ovarian artery circulation, which supports the ovary and INF/AMP, contribute to this region‐specific vacuolation phenotype, as a consequence of a mildly ...
Keerthana Harwalkar, Nobuko Yamanaka, Alain S. Pacis, Selina Zhao, Katie Teng, Warwick Pitman, Mitaali Taskar, Vera Lynn, Alex Frances Thornton, Matthew J. Ford, Yojiro Yamanaka   +10 more
wiley   +1 more source

Targeting IGF1‐Induced Cellular Senescence to Rejuvenate Hair Follicle Aging

Aging Cell, Volume 24, Issue 7, July 2025.
Age‐related increases in IGF‐1 expression in the skin accelerate stem cell exhaustion and senescence by impairing SIRT1 function, ultimately driving hair follicle aging. Conversely, activating SIRT1, clearing senescent cells, or adopting dietary restriction can mitigate excessive IGF‐1 signaling and provide a promising strategy to rejuvenate hair ...
Yang Wang, Jian Yang, Yue Luo, Zhiqiang Zhao, Yawen Yuan, Juan Li, Yang Liu, Yong Yi, Xiaoke Xu, Yuankunyu Lan, Juan Zou, Qintong Li, Liang Wang, Yang Pan, Yuanhan Yang, Muzhao Xiong, Min Wu, Jinsong Li, Weiyuxin Li, Yujun Zhang, Yang Cao, Yi Zhu, Zhi‐Xiong Jim Xiao   +22 more
wiley   +1 more source

Phenotype and gene signature of testicular tumors in 129.MOLF‐Chr19 mice resemble human teratomas

Andrology, Volume 13, Issue 5, Page 1213-1222, July 2025.
Abstract Background Testicular germ cell tumor (TGCT) is the most common type of tumor in young men. Type II germ cell tumors including postpubertal‐type teratomas are derived from the germ cell neoplasia in situ (GCNIS), whereas prepubertal‐type teratomas arise independently of the GCNIS.
Fabian A. Gayer, Lucas Klaus, Sybille D. Reichardt, Alexander Fichtner, Holger M. Reichardt   +4 more
wiley   +1 more source

Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders

British Journal of Pharmacology, Volume 182, Issue 14, Page 3044-3067, July 2025.
Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi, Caroline Gora, Ana Dudas, Xavier Leray, Véronique Bozon, Pascale Crépieux, Lucie P. Pellissier   +6 more
wiley   +1 more source

Sociability and preference for social novelty in five inbred strains: an approach to assess autistic‐like behavior in mice

Genes, Brain and Behavior, 2004
S. Moy, Jessica J. Nadler, Antonio Perez, R. P. Barbaro, J. Johns, Terry R. Magnuson, J. Piven, J. Crawley, J. Crawley   +8 more
semanticscholar   +1 more source

A locus conferring resistance to diet-induced hypercholesterolemia and atherosclerosis on mouse chromosome 2

Journal of Lipid Research, 2000
Dietary cholesterol is known to raise total and low density lipoprotein cholesterol concentrations in humans and experimental animals, but the response among individuals varies greatly.
Aram Mouzeyan, Junghee Choi, Hooman Allayee, Xuping Wang, Janet Sinsheimer, Jack Phan, Lawrence W. Castellani, Karen Reue, Aldons J. Lusis, Richard C. Davis   +9 more
doaj  

Assessment of hearing in 80 inbred strains of mice by ABR threshold analyses

Hearing Research, 1999
Q. Zheng, K. Johnson, L. Erway
semanticscholar   +1 more source

Comt1 genotype and expression predicts anxiety and nociceptive sensitivity in inbred strains of mice

Genes, Brain and Behavior, 2010
S. Segall, A. Nackley, L. Diatchenko, William R. Lariviere, X. Lu, J. S. Marron, Laura Grabowski-Boase, John R. Walker, G. Slade, Josee Gauthier, Janice S. Bailey, B. Steffy, Thomas M. Maynard, L. Tarantino, Tim Wiltshire   +14 more
semanticscholar   +1 more source

Relationship between phospholipid transfer protein activity and HDL level and size among inbred mouse strains

Journal of Lipid Research, 1999
Because of the paucity of data on phospholipid transfer protein (PLTP) activity and lipoprotein phospholipid in mouse strains, plasma PLTP activity (PLTA), plasma phospholipid and cholesterol, HDL phospholipid and cholesterol, and HDL size distribution ...
John J. Albers, Wendy Pitman, Gertrud Wolfbauer, Marian C. Cheung, Hal Kennedy, An-Yue Tu, Santica M. Marcovina, Beverly Paigen   +7 more
doaj