Results 131 to 140 of about 151,615 (262)

Preclinical Characterization and Clinical Activity of RNK08954, a Highly Selective and Orally Bioavailable KRASG12D Inhibitor. [PDF]

Cancer Discov
Xie L, Xu C, Si H, Fu X, Yang X, Jin J, Yu X, Shao Z, Wang Y, Chu T, Zhang J, Liang R, Meng R, Fei Y, Song H, Ying C, Dai Y, Wang Y, Ei-Hariry I, Wang G, Ying W, Song Z.   +21 more
europepmc   +1 more source

A Non‐Canonical Core Transcriptional Regulatory Circuit Orchestrates Chromatin Reprogramming to Drive Osimertinib Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
A non‐canonical core transcriptional regulatory circuit, composed of ID3, SMAD3, and NR2F2, drives Osimertinib resistance in non‐small cell lung cancer through super‐enhancer‐mediated activation of EPAS1, which couples neuroendocrine differentiation with ferroptosis evasion.
Aochu Liu, Zhenguo Liu, Lizhen Jiang, Andong Huang, Xinqing Lin, Xinyue Li, Bingyuan Liu, Shiwen Hu, Qiang Pan, Junjun Huang, Liyuan Yin, Liling Jiang, Wei Yi, Wenjun Mao, Yueyuan Zheng, Xianping Shi   +15 more
wiley   +1 more source

Preclinical ^203/212Pb-DOTA-Based Pretargeted Radioimmunotherapy in Nude Mice Bearing Established Human Colorectal Cancer Xenografts. [PDF]

J Nucl Med
Vaughn BA, Veach DR, Vargas DB, Seo S, Punzalan B, Rinne SS, Fung EK, Xu H, Guo HF, Yang G, Ouerfelli O, Carrasco SE, St Jean S, Cheung NV, Larson SM, Cheal SM.   +15 more
europepmc   +1 more source

Bandgap‐Engineered PtxTey:Ag2Te Composite Quantum Dots Enable Programmable NIR‐II Imaging and Photothermal‐Immune Synergistic Therapy

Advanced Science, EarlyView.
A bandgap‐engineered PtxTey:Ag2Te quantum dot platform enables tunable NIR‐IIb emission for deep‐tissue imaging and mild photothermal therapy. Conjugation with αPD‐L1 confers dual tumor targeting and real‐time monitoring of PD‐L1 dynamics. Mild photothermal modulation induces immune reprogramming, enhancing checkpoint blockade efficacy and achieving ...
Jing Liu, Rui Xu, Quan Wu, Tian‐Xin Xiao, Lai‐Xi Zhao, Lei Sun, Ya‐Wen Zheng, Liang Dong, Zhi‐Quan Tian, Haibo Wang   +9 more
wiley   +1 more source

Establishment and characterization of an immortalized bovine luteal cell line. [PDF]

Front Vet Sci
Fei G, Zhao Z, Zeng M, Liang Y, Miao T, Liu Y, Yang J, Chen S, Zhu X, Wang J.   +9 more
europepmc   +1 more source

PGK1 Suppresses CD8+ T Cell‐Mediated Antitumor Immunity Through CCL2/CCR2/Tumor‐Associated Macrophages Axis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
PGK1 in tumor cells upregulates CCL2 expression through activation of the AKT/GSK‐3β/β‐catenin signaling axis, thereby promoting the recruitment and M2 polarization of TAMs and ultimately impairing the infiltration and activation of CD8+ T cells within the HCC tumor microenvironment. ABSTRACT Patients with advanced hepatocellular carcinoma (HCC) have a
Xi Liu, Jianpeng Liu, Zhihao Zhang, Xizhi Yu, Junjie Qian, Limin Ding, Qinchuan Wu, Zhe Yang, Xing‐Yu Luo, Xinjiang Ding, Rong Su, Xiaobo Yu, Yiting Qiao, Shengyong Yin, Haiyang Xie, Lin Zhou, Yuanxing Liu, Shusen Zheng   +17 more
wiley   +1 more source

Localization of Dengue Virus in Nude Mice [PDF]

Microbiology and Immunology, 1981
H, Hotta, I, Murakami, K, Miyasaki, Y, Takeda, H, Shirane, S, Hotta   +5 more
openaire   +2 more sources

Methionine Restriction Alone Induces T-cell-mediated Immunotherapy of Osteosarcoma in a Syngeneic Mouse Model. [PDF]

In Vivo
Mizuta K, Kubota Y, Aoki Y, Morinaga S, Asano Y, Miyashi Y, Bouvet M, Tome Y, Nishida K, Hoffman RM.   +9 more
europepmc   +1 more source

A Non‐Canonical Role of SMAD4 in Regulating 3D Genome Architecture to Inhibit Lung Squamous Cell Carcinoma Development

Advanced Science, EarlyView.
SMAD4 is identified as a guardian of 3D genome architecture in lung squamous cell carcinoma. Loss of SMAD4 unleashes EP300 at chromatin loop anchors, strengthening enhancer–promoter looping and H3K27ac at the SOX2 locus to drive aberrant SOX2 activation and tumor cell proliferation.
Qian Tang, Chen Lian, Xinyan Han, Xuhan Zhang, Zihan Wang, Boyu Wang, Taoyu Zhu, Xinrui Lin, Xiaolei Wang, Yaping Xu, Manyu Xiao, Zijin Wang, Junming Li, Silin Chen, Yunze Wang, Yufei Liu, Songsong Li, Zuolin Shen, Xi Lu, Xueqi Han, Yilu Zhou, Mingyang Xiao, Jiayi Ran, Xiaoran Cao, Xinyi Xu, Hugo Sámano‐Sánchez, Alfredo Rodríguez, Lian Wang, Shuifang Chen, Zhanyu Xu, Shirong Zhang, Nuo Yang, Yong Tang, Jian Liu   +33 more
wiley   +1 more source

Exploring the 89Zr/177Lu Theranostic Pairing with an Extracellular Matrix-Targeted Radiopharmaceutical against Triple-Negative Breast Cancer. [PDF]

Clin Cancer Res
Hachey JS, Viray TD, Carrasco SE, Carter LM, Esposito TVF, Matasci M, Ravazza D, Neri D, Lewis JS.   +8 more
europepmc   +1 more source