Results 201 to 210 of about 151,615 (262)

Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer

Advanced Science, EarlyView.
This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, Xiaowu Dong, Jinzhou Huang, Xing Huang, Kai Miao, Qian Hua, Fangfang Tao, Weidong Zhang, Jiang‐Jiang Qin   +17 more
wiley   +1 more source

Agent-based modeling demonstrates how target-independent processes supplement killing by antibody-drug conjugates in cancer therapy. [PDF]

PLoS Comput Biol
Calopiz MC, Linderman JJ, Thurber GM.
europepmc   +1 more source

REGγ Suppresses Ferroptosis and Induces Drug Resistance by Degrading WDR6 in Chondrosarcoma

Advanced Science, EarlyView.
Here, we identified REGγ as a susceptibility factor in chondrosarcoma. Our study demonstrates that abnormally activated REGγ‐20S proteasome promotes chondrosarcoma development and progression. Further validation in animal models revealed that blocking REGγ function induced ferroptosis, suppressed malignant progression of chondrosarcoma, and uncovered a
Fanrong Liu, Shihui Shen, Dongxia Li, Peilin Shi, Jiaming Xu, Tongxin Lv, Yingying Du, Jingwei Zhang, Bo Yang, Hansen Chen, Zhuoya Peng, Wenjie Ren, Lu Zhang, Sheng Cheng, Tongjin Yin, Wencai Sheng, Lei Li, Juan Wu, Qingcheng Yang, Shuogui Xu, Wei Zheng   +20 more
wiley   +1 more source

Matrix-free cryo-microneedles array patch for 3D hair follicle organoids delivery and rapid hair regeneration. [PDF]

Mater Today Bio
Wang S, Sun J, Li Y, Zhou Y, Cai Y, Simayijiang Z, Gu Z, Xie Z.   +7 more
europepmc   +1 more source

Dual-ligand-modified cantharidin nanoparticles for the treatment of hepatocellular carcinoma via the inhibition of Ephb4. [PDF]

Drug Deliv
Jiang W, Zheng H, Wang S, Xu R, Chen X, Yang J, Xia X.   +6 more
europepmc   +1 more source

MEK inhibitor cobimetinib increases calreticulin and induces immune modulation in TNBC. [PDF]

J Mol Med (Berl)
Tseng LM, Lau KY, Chen JL, Chu PY, Huang CT, Wang WL, Chang YY, Lai JI, Huang CC, Dai MS, Liu CY.   +10 more
europepmc   +1 more source

Tanshinone IIA inhibits epithelial-mesenchymal transition in ovarian cancer by promoting NR3C2 transcriptional activation of ING1. [PDF]

iScience
Wang X, Zhang D, Wang T, Li X, Zhang J.
europepmc   +1 more source

Reversing ABCB1-Mediated Multidrug Resistance in Colorectal Cancer: electroacupuncture shows therapeutic potential <i>in vivo</i>. [PDF]

J Pharmacopuncture
Qiu Y, Fan Z, Qi X, Jiang H, Zhao W, Wan Y, Huang J.   +6 more
europepmc   +1 more source

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Tamoxifen administration and metabolism in nude mice and nude rats

Journal of Steroid Biochemistry and Molecular Biology, 2003
We investigated the kinetics of tamoxifen (tam) in immunodeficient mice and rats after oral treatment and compared drug and metabolite profile in nude rat serum and tissues after oral and subcutaneous (s.c.) routes of administration. The serum levels were compared to those observed in man.
Gunnar Mellgren, E A Lien
exaly   +3 more sources

Toxoplasmosis in Nude Mice

The Journal of Parasitology, 1977
Immunity to the intracellular protozoan, Toxoplasma gondii, in mice is of the premunition type. Chemoprophylaxis with sulfadiazine normally permits mice to develop immunity to virulent organisms. However, nude (nu/nu) mice, which lack the thymus, failed to develop immunity to toxoplasma during 3 weeks of drug therapy while their hirsute littermates ...
Lindberg, R E, Frenkel, J K
openaire   +2 more sources