Results 11 to 20 of about 2,313,243 (300)
FcRn Expression in Wildtype Mice, Transgenic Mice, and in Human Tissues. [PDF]
Biomolecules, 2018 Quantitative real-time PCR and Western blot methods were developed to assess neonatal Fc-receptor (FcRn) mRNA and protein expression in human FcRn transgenic mice, Swiss Webster mice, and in select human tissues. Additionally, FcRn turnover was evaluated
Li T, Balthasar JP.
europepmc +2 more sources
PLoS ONE, 2012 The effects of tau hyperphosphorylation and aggregation on axonal transport were investigated in the optic nerve of mice transgenic for human mutant P301S tau. Transport was examined using cholera toxin B tracing.
Natalie D Bull +4 more
doaj +2 more sources
Molecules, 2022 COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global pandemic that might lead to very serious consequences. Notably, mental status change, brain confusion, and smell and taste disorders along with neurological ...
Simona Dedoni +6 more
doaj +1 more source
Tiam1 transgenic mice display increased tumor invasive and metastatic potential of colorectal cancer after 1,2-dimethylhydrazine treatment. [PDF]
PLoS ONE, 2013 BACKGROUND: T lymphoma invasion and metastasis 1 (Tiam1) is a potential modifier of tumor development and progression. Our previous study in vitro and in nude mice suggested a promotion role of Tiam1 on invasion and metastasis of colorectal cancer (CRC).
Li-Na Yu +7 more
doaj +1 more source
Transgenic Mouse Models for the Study of Neurodegenerative Diseases
Frontiers in Bioscience-Landmark, 2023 Neurodegenerative diseases (NDs) are some of the most important health challenges modern medicine and advanced societies face. Indeed, the number of patients affected by one of these illnesses will increase in the following years at the same rate that ...
Alba Marín-Moreno +4 more
doaj +1 more source
Comparative Analysis of Gastrointestinal Microbiota Between Normal and Caudal-Related Homeobox 2 () Transgenic Mice [PDF]
Intestinal Research, 2015 Background/AimsCaudal-related homeobox 2 (Cdx2) is expressed in the human intestinal metaplastic mucosa and induces intestinal metaplastic mucosa in the Cdx2 transgenic mouse stomach.
Hirotsugu Sakamoto +7 more
doaj +1 more source
Low CD4/CD8 T-cell ratio associated with inflammatory arthropathy in human T-cell leukemia virus type I Tax transgenic mice. [PDF]
PLoS ONE, 2011 BACKGROUND: Human T-cell leukemia virus type I (HTLV-1) can cause an aggressive malignancy known as adult T-cell leukemia/lymphoma (ATL) as well as inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP).
Takeo Ohsugi, Toshio Kumasaka
doaj +1 more source
Thy1 transgenic mice expressing the red fluorescent calcium indicator jRGECO1a for neuronal population imaging in vivo. [PDF]
PLoS ONE, 2018 Calcium imaging is commonly used to measure the neural activity of large groups of neurons in mice. Genetically encoded calcium indicators (GECIs) can be delivered for this purpose using non-invasive genetic methods.
Hod Dana +8 more
doaj +1 more source
Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice
Nature Communications, 2020 Vaccine and antiviral development against SARS-CoV-2 infection or COVID-19 disease would benefit from validated small animal models. Here, we show that transgenic mice expressing human angiotensin-converting enzyme 2 (hACE2) by the human cytokeratin 18 ...
Fatai S. Oladunni +41 more
semanticscholar +1 more source
Journal of Diabetes Research, 2021 To rigorously explore the role of omega-3 polyunsaturated fatty acids (PUFA) in the treatment of diabetic peripheral neuropathy (DPN), we have created a transgenic mouse utilizing a Cre-lox promoter to control overexpression of human 15-lipoxygenase-1 ...
Lawrence Coppey +5 more
doaj +1 more source