Results 191 to 200 of about 3,675,695 (304)

CircTspan3 Promotes Cartilage Development Through ANNEXIN A2‐Mediated Ferroptosis and Apoptosis Inhibition and Exosome‐Mediated Paracrine Signaling

Advanced Science, EarlyView.
This study reveals that XBP1s drives production of circTspan3, a circular RNA that strengthens cartilage by boosting anabolic activity and limiting cell death. Phosphorylated ANXA2 directs circTspan3 into exosomes, enabling paracrine repair. Exosomal circTspan3 expands growth‐plate cartilage and promotes in vivo regeneration, highlighting its promise ...
Yiming Pan, Fengmei Zhang, Jiayan Zhong, Qian Gong, Nana Geng, Biao Kuang, Qiumei Lan, Miao Yi, Qiqi Zeng, Cheng Chen, Mengtian Fan, Chunliang Zhao, Deping Zeng, Yu Du, Mao Nie, Zhibiao Wang, Fengjin Guo   +16 more
wiley   +1 more source

Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.

EMBO Journal, 1991
J. Keffer, L. Probert, Haris Caziaris, S. Georgopoulos, E. Kaslaris, D. Kioussis, G. Kollias   +6 more
semanticscholar   +1 more source

Identification and Mechanisms of Osteocyte Subsets Involved in the Pathological Progression of Osteoporosis

Advanced Science, EarlyView.
Osteocyte heterogeneity in bone remains poorly understood. This study identifies six distinct osteocyte subsets in mice, revealing a key subpopulation (BHR‐Ocys) that drives bone loss in osteoporosis. BHR‐Ocys promote osteoclast‐mediated resorption via a novel Sema5a‐Plxna1 signaling axis.
Zengxin Jiang, Biyu Rui, Xuecheng He, Jiajun Wang, Xiangdong Wu, Rui Shao, Xue Meng, Xiaochun Peng, Hengfeng Yuan   +8 more
wiley   +1 more source

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

Nature, 1988
P. Kisielow, H. Blüthmann, U. Staerz, M. Steinmetz, H. Boehmer   +4 more
semanticscholar   +1 more source

A Modular Vaccine Platform Against SARS‐CoV‐2 Based on Self‐Assembled Protein Nanoparticles

Advanced Science, EarlyView.
A modular BP26 nanoparticle vaccine platform incorporating the SpyTag/SpyCatcher system enables high‐density, repetitive antigen display with post‐expression flexibility. Conjugation of the SARS‐CoV‐2 RBD to BP26 nanoparticles elicits strong humoral immunity and confers protection against viral challenge in vivo.
Seojung Lee, Yejin Jang, Yujin Kim, Yumi Shin, Ji‐Joon Song, Meehyein Kim, Sangyong Jon   +6 more
wiley   +1 more source

Co-presence of classical scrapie but not classical Bovine Spongiform Encephalopathy in transmissions from Dutch sheep with atypical scrapie. [PDF]

J Gen Virol
van Keulen LJ, Dolstra CH, Bossers-de Vries R, Bossers A.   +3 more
europepmc   +1 more source

Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia

Advanced Science, EarlyView.
Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with
Yijie Shen, Jiale Wei, Shibing Tang, Dongliang Wu, Liangyi Zong, Shuyuan Ma, Qing Xiong, Ruijie Gong, Siyuan Xu, Chuxuan Peng, Qin Feng, Songchen Liu, Qitong Liu, Yuhua Ye, Quan Zhao, Cheng Luo, Peng Huang, Zhihai Li, Xiangqian Kong, Xianjiang Lan   +19 more
wiley   +1 more source

Behavior‐ and Cell Type‐Specific Cortico‐Striatal Decoupling in a Parkinson's Disease‐Like Mouse Model

Advanced Science, EarlyView.
Utilizing dual‐site fiber photometry, this study examines cortico‐striatal coupling with cell type resolution, identifying behavior‐ and cell type‐specific cortico striatal decoupling and its dopamine‐dependent mechanism in a Parkinson's disease mouse model.
Xu‐Ran Yao, Yang Liu, Wei‐Tong Zheng, Mao‐Qing Huang, Kai‐Wen He   +4 more
wiley   +1 more source

AldoC BAC-GFP transgenic mice as a reliable model for astrocyte identification and functional studies in the brain. [PDF]

Mol Brain
Kim J, Yang H, Kim SS, Cho E, Her S, Hwang EM, Shim S, Park JY.   +7 more
europepmc   +1 more source

Mice Transgenic for a Human Porcine Endogenous Retrovirus Receptor Are Susceptible to Productive Viral Infection

Journal of Virology, 2006
Y. Martina, K. Marcucci, S. Cherqui, A. Szabo, T. Drysdale, U. Srinivisan, Carolyn Wilson, C. Patience, D. Salomon   +8 more
semanticscholar   +1 more source