Results 181 to 190 of about 1,947,841 (302)

Methylomic signatures of tau and amyloid-beta in transgenic mouse models of Alzheimer's disease neuropathology. [PDF]

NPJ Dement
Leung SK, Walker EM, Policicchio S, Dahir A, Vellame DS, Smith AR, Swarbrick R, Lunnon K, Dempster EL, Ahmed Z, Hannon E, Castanho I, Mill J.   +12 more
europepmc   +1 more source

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source

Efficient generation of single-copy transgenic mice using piggyBat transposase from the little brown bat Myotis lucifugus†. [PDF]

Biol Reprod
Okamura E, Matsumoto S, Suzuki H, Tanimoto Y, Dinh TTH, Mikami N, Muto M, Matsumoto T, Sugiyama F, Takahashi S, Woltjen K, Mizuno S, Ema M.   +12 more
europepmc   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Modification of early behavioural, physiological and neuropathological endpoints by syntaxin-6 knockout in a humanised P301S transgenic model of tauopathy. [PDF]

Acta Neuropathol
Hill E, Linehan J, Farmer M, Jakubcova T, Hamdan S, Tomlinson A, Purro S, Argentina F, Jones E, Kaye N, Fitzhugh C, de Silva R, Brandner S, Collinge J, Cunningham TJ, Mead S.   +15 more
europepmc   +1 more source

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

In vivo Assessment of the Potential Protective Effects of Traditional Kumis Against SARS-CoV-2 in a Transgenic Mouse Model. [PDF]

Food Environ Virol
Kocaman B, Aydin HN, Istanbullugil FR, Sahin M, Bayraktar IA, Ekiz AT, Yaman OA, Polat HU.   +7 more
europepmc   +1 more source

GCaMP transgenic mice [PDF]

Nature Methods, 2012
openaire   +1 more source

Deciphering the Impact of RAC1‐SPTAN1 in ARPKD Cystogenesis Using Multifaceted Models

Advanced Science, EarlyView.
Distal/connecting tubules expressing SLC8A1 have been suggested as a potential origin of ARPKD cysts. SPTAN1 has been identified as a key molecule in ARPKD cyst formation. Restoring SPTAN1 in PKHD1−/− organoids reduced cyst formation, normalized calcium levels, and decreased RAC1/c‐FOS expression, highlighting SPTAN1's role in ARPKD and the potential ...
Shohei Kuraoka, Yuhei Higashi, Suguru Saito, Solmaz Pourgonabadi, Honami Honjoh, Sho Ishigaki, Peter C. Harris, Lisa M. Satlin, Michifumi Yamashita, Ryuji Morizane   +9 more
wiley   +1 more source

Complement activation and M2-like macrophage accumulation in anti-MDA5 monoclonal antibody-induced hepatic injury in mice. [PDF]

Front Immunol
Koga T, Zaizen Y, Suzuki H, Sugi S, Hozumi H, Sakamoto N, Suda T, Mukae H, Kusano H, Kawahara A, Akiba J, Kawaguchi T, Kaieda S, Hoshino T.   +13 more
europepmc   +1 more source