Results 191 to 200 of about 1,947,841 (302)

Molecularly Engineered Phenoxazinone‐Skeleton Cascade‐Activated NIR Probes for Monitoring Fe2+/Viscosity in Ferroptosis‐Mediated Parkinson's Disease

Advanced Science, EarlyView.
A series of Fe2+/viscosity cascade‐activated NIR fluorescence probes (NP1–5) are synthesized, and NP3 is selected for its optimal properties. To verify application of NP3 in ferroptosis intervention in PD, PQR NPs, is constructed by NP3 and quercetin self‐assembling.
Lixia Guo, Tao Liu, Hongfei Wang, Qi Gao, Zhaobo Yang, Zumeng Wang, Chenlong Li, Yubing Kang, Kahleong Lim, Wen Liu, Li Lu, Chengwu Zhang   +11 more
wiley   +1 more source

Human umbilical cord mesenchymal stem cells therapy for Alzheimer's disease: a systematic review and meta-analysis of mouse models. [PDF]

Front Neurol
Si C, Ma L, Ding W, Tian Y, Zhang J, Cao H, Shao Y, Fan Z.   +7 more
europepmc   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Modest rescue of RBFOX1 splicing function attenuates Huntington's disease features. [PDF]

Mol Med
Lozano-Muñoz D, Elorza A, Lucas-Santamaría M, Santos-Galindo M, Parras A, Lucas JJ.   +5 more
europepmc   +1 more source

Deep Volumetric Super‐Resolution Imaging in Thick Biological Specimens With Sparse Scanning SIM

Advanced Science, EarlyView.
Sparse scanning structured illumination microscopy (SS‐SIM) extends the axial depth in super‐resolution fluorescence imaging by combining rapid laser scanning, pixel‐addressed intensity modulation, and sCMOS camera detection. SS‐SIM yields 1.6× lateral and 1.7× axial resolution gains over wide‐field microscopy and enables imaging through 300–600 µm ...
Sha An, Xuhong Guo, Zhongxia Cai, Yunze Lei, Kai Wen, Hongfei Suo, Xiaoyu Kong, Gerd Ulrich Nienhaus, Peng Gao   +8 more
wiley   +1 more source

Restoring <i>Ag1</i>, an ancient regeneration gene lost in amniotes, accelerates skin healing in mice. [PDF]

Front Cell Dev Biol
Kosykh AV, Zhigmitova EB, Evtushenko NA, Gurskaia TH, Martynova AA, Silaeva YY, Ivanova AS, Martynova NY, Tereshina MB, Rudyak SG, Panteleyev AA, Makarenkova HP, Gurskaya NG, Lukyanov SA, Zaraisky AG.   +14 more
europepmc   +1 more source

Plant‐Derived Melatonin Inhibits Bacterial Virulence via CpxA/R Two‐Component System

Advanced Science, EarlyView.
Plant‐derived melatonin is sensed by CpxAE48/T51, which inhibits the phosphorylation cascade transmission from CpxAH240 to CpxRD52, resulting in the inhibition of DNA‐binding capacity of CpxR and subsequent T3SS genes expression in Pst DC3000. ABSTRACT In defending against pathogens, plants deploy diverse secondary metabolites and signaling molecules ...
Jin‐Wei Wei, Wei Liu, Bili Cao, Dan Zhao, Chengqiang Wang, Xin Hou, Tangyuan Ning, Biao Gong   +7 more
wiley   +1 more source

Fluorescence Detection of Alpha-Synuclein Aggregates in the Gut Using a Peptide Probe. [PDF]

ACS Chem Neurosci
Sim R, Lee J, Chieng J, Tan KH, Lim G, Foo A, Wong SH, Lim KL, Liang K.   +8 more
europepmc   +1 more source

Kinsenoside Targets IDH1 to Restore Microglial Immune‐Metabolic Homeostasis for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li, Yajin Liao, Yan‐bo Zhao, Hongxing Wu, Tong Jin, Shuoshuo Li, Yuhan Liu, Peng Li, Songying Ouyang, Zekai Li, YuTing Xia, Qian Hua, Rui‐Yuan Pan, Zengqiang Yuan   +13 more
wiley   +1 more source

The common and specific osteoarthritis gait characteristics: A quantitative grading system for OA associated gait changes in mice. [PDF]

Osteoarthr Cartil Open
Liu Y, Knebel A, Ding J, Jay G, Chen Q.
europepmc   +1 more source