Results 221 to 230 of about 1,897,120 (285)

Cardiac CapZ Regulation During Acute Exercise in Female Mice. [PDF]

FASEB J
Townsend LK, Wright D, Pyle WG.
europepmc   +1 more source

PDGFRα+DPP4+ Fibroblasts‐Macrophage Crosstalk Induces Orbital Fibrosis in Treatment‐Resistant Thyroid Eye Disease via the GAS6‐AXL Pathway

Advanced Science, EarlyView.
This study elucidates macrophage‐induced orbital fibrosis in TED via the GAS6‐AXL pathway, a treatment‐resistant disorder lacking non‐surgical therapies. Using a novel patient cell‐derived orthotopic animal model of orbital fibrosis for TED, we repurpose an existing fibrosis therapy, addressing the absence of stable models and offering a potential ...
Lu Cheng, Jinwei Cheng, Guiling Liang, Xiaorui Wang, Yanwen Ge, Jiapei Liu, Luwei Cai, Hui Ying, Fenfen Wang, Jing Hu, Yufan Wang, Philipp E. Scherer, Ben Zhou, Mengle Shao, Fang Zhang   +14 more
wiley   +1 more source

Transgenic expression of the human Glucose Transporter1 (GLUT1) gene locus reduces disease burden in Glut1 deficiency syndrome model mice. [PDF]

Neurobiol Dis
Tang M, Teng S, Kim AY, Peng Y, Monani UR.   +4 more
europepmc   +1 more source

High‐Throughput Strategies for Streamlining Lipid Nanoparticle Development Pipeline

Advanced Science, EarlyView.
This review highlights emerging state‐of‐the‐art high‐throughput strategies for optimising lipid nanoparticle formulation. By integrating combinatorial design, characterization, in vitro/in vivo screening, automation, and machine learning into a closed‐loop framework, it provides a roadmap to streamline discovery and accelerate the translation of ...
Lois Lam, Stephanie Watson, Yogambha Ramaswamy, Gurvinder Singh   +3 more
wiley   +1 more source

Mechanism of Tiaogeng decoction in a cognitive dysfunction mouse model. [PDF]

J Tradit Chin Med
Shuang NI, Xiaofei L, Xiaoyan G, Zuxi GU, Panqing WU, Chao C, Shengnan LI, Xianwei G, Lianwei XU.   +8 more
europepmc   +1 more source

A Transmembrane Protein WAI‐B2 Confers Multiple Disease Resistance in Wheat by Activating Autoimmunity

Advanced Science, EarlyView.
Wheat production is under threat from multiple diseases. This study clones the wheat autoimmunity gene WAI‐B2 from an EMS‐induced mutant that encodes a distinct transmembrane protein conferring resistance to wheat rusts and powdery mildew ‐ two major diseases affecting wheat crops.
Wenling Li, Yongxing Chen, Lei Dong, Guanghao Guo, Huaizhi Zhang, Tao Shen, Gaojie Wang, Lingli Dong, Ping Lu, Miaomiao Li, Dan Qiu, Keyu Zhu, Beibei Li, Yikun Hou, Xuejia Cui, Baoge Huang, Fugang Yang, Hongkui Fu, Delin Li, Zhan Li, Jinghuang Hu, Yunfeng Qu, Huanhuan Lou, Shisheng Chen, Zaifeng Li, Ling Kang, Wuyun Yang, Chengguo Yuan, Hongjie Li, Yusheng Zhao, Zhiyong Liu, Haiyan Jia, Qiuhong Wu   +32 more
wiley   +1 more source

What can Animal Models tell us About T Cells in Spondyloarthritis Pathogenesis? [PDF]

Curr Rheumatol Rep
Smith JA.
europepmc   +1 more source

Polo‐Like Kinase 1 Phosphorylation Tunes the Functional Viscoelastic Properties of the Centrosome Scaffold

Advanced Science, EarlyView.
To enable mitotic spindle assembly during cell division, centrosomes must bear tensile stresses generated by microtubule‐mediated pulling forces. Micro‐rheology reveals that PLK‐1 phosphorylation of the scaffold protein SPD‐5 tunes the viscoelasticity, size, and morphology of the centrosome scaffold in C. elegans.
Matthew Amato, June Ho Hwang, Manolo U. Rios, Nicole E. Familiari, Michael K. Rosen, Jeffrey B. Woodruff   +5 more
wiley   +1 more source

Spatial metabolomics reveals the effects of Acanthopanax senticosus on region-specific alterations in neurotransmitters and metabolites levels in the brains of α-syn transgenic Parkinson's disease model mice. [PDF]

Metab Brain Dis
Zheng Q, Lu Y, Yu D, Zhao L, Wang Y, Chen P, Lu F, Liu S.   +7 more
europepmc   +1 more source

Vitamin D Binding Protein, a Ligand of Integrin beta 1, Motivates Both Tumor Cells and Schwann Cells to Promote Perineural Invasion in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
Group‐specific component protein (GC) promotes perineural invasion (PNI) in pancreatic ductal adenocarcinoma (PDAC) by activating Schwann cell dedifferentiation and by enhancing tumor–Schwann cell chemoattraction, independently of vitamin D transport. Integrin β1 (ITGB1) functions as a GC receptor in both cancer cells and Schwann cells.
Shan Zhang, Luju Jiang, Shuqi Cai, Zheqi Weng, Yuheng Zhu, Zhi‐Wei Cai, Hui Li, Qing Li, Li‐Peng Hu, Hong‐Fei Yao, Rong Hua, Yu Zhao, Dongxue Li, Xiao‐Mei Yang, Jun‐Feng Zhang, Shu‐Heng Jiang   +15 more
wiley   +1 more source