Results 221 to 230 of about 2,313,243 (300)

Proteomic Profiling of the Large‐Vessel Vasculitis Spectrum Identifying Shared Signatures of Innate Immune Activation and Stromal Remodeling

Arthritis &Rheumatology, EarlyView.
Objective Takayasu arteritis (TAK) and giant cell arteritis (GCA), the most common forms of large‐vessel vasculitis (LVV), can result in serious morbidity. Understanding the molecular basis of LVV should aid in developing better biomarkers and treatments. Methods Plasma proteomic profiling of 184 proteins was performed in two cohorts. Cohort 1 included
Robert T. Maughan, Erin Macdonald‐Dunlop, Lubna Haroon‐Rashid, Louise Sorensen, Natalie Chaddock, Shauna Masters, Andrew Porter, Marta Peverelli, Charis Pericleous, Andrew Hutchings, James Robinson, Taryn Youngstein, Raashid A. Luqmani, Justin C. Mason, Ann W. Morgan, James E. Peters   +15 more
wiley   +1 more source

A human-ACE2 knock-in mouse model for SARS-CoV-2 infection recapitulates respiratory disorders but avoids neurological disease associated with the transgenic K18-hACE2 model. [PDF]

mBio
Pons-Grífols A, Tarrés-Freixas F, Pérez M, Riveira-Muñoz E, Raïch-Regué D, Perez-Zsolt D, Muñoz-Basagoiti J, Tondelli B, Pradenas E, Izquierdo-Useros N, Capdevila S, Vergara-Alert J, Urrea V, Carrillo J, Ballana E, Forrow S, Clotet B, Segalés J, Trinité B, Blanco J.   +19 more
europepmc   +1 more source

Mitochondria and Endoplasmic Reticulum Contact Site as a Regulator of Proteostatic Stress Responses in Neurodegenerative Diseases

BioEssays, EarlyView.
Recent findings indicate that mitochondria‐associated membranes (MAMs), where the endoplasmic reticulum directly contacts the mitochondria, are a novel microdomain essential for cellular homeostasis, including proteostasis. We summarize the disruption of protein homeostasis and MAM alteration in neurodegenerative diseases, then discuss challenges and ...
Seiji Watanabe, Koji Yamanaka
wiley   +1 more source

AARS2 ameliorates myocardial ischemia <i>via</i> fine-tuning PKM2-mediated metabolism. [PDF]

Elife
Zhang Z, Zheng L, Chen Y, Chen Y, Hou J, Xiao C, Zhu X, Zhao SM, Xiong JW.   +8 more
europepmc   +1 more source

Improved engraftment of human acute myeloid leukemia progenitor cells in beta 2-microglobulin-deficient NOD/SCID mice and in NOD/SCID mice transgenic for human growth factors

Leukemia, 2003
M. Feuring‐Buske, B. Gerhard, J. Cashman, R. Humphries, C. Eaves, Hogge De   +5 more
semanticscholar   +1 more source

The contribution of extracellular RNA and its derived biomaterials in disease management

BMEMat, EarlyView.
The implications of exRNA's biological function and the structural uniqueness of RNA help establish a close connection between RNA, material, and modern medicine. Abstract The RNA found in the circular system is known as extracellular RNA (exRNA). This kind of RNA has been found to play a biological role similar to that of a messenger. They can be used
Yu Wei, Zhangyi Wang, Zixuan Qin, Qianqian Wan, Yutao Li, Franklin R. Tay, Chenyu Wang, Tong Zhang, Lina Niu   +8 more
wiley   +1 more source

Correction: Urolithin a Improves Motor Dysfunction Induced by Copper Exposure in SOD1^G93A Transgenic Mice Via Activation of Mitophagy. [PDF]

Mol Neurobiol
Zhang H, Gao C, Yang D, Nie L, He K, Chen C, Li S, Huang G, Zhou L, Huang X, Wu D, Liu J, Huang Z, Wang J, Li W, Zhang Z, Yang X, Zou L.   +17 more
europepmc   +1 more source

Engineering antibodies with cancer‐associated binding sites

BMEMat, EarlyView.
This review describes antibodies that perform direct/indirect roles in cancer treatment by binding to effective targets and discusses how antibodies kill tumors and modulate tumor microenvironment through these targets. The classification of expression systems for antibody production is summarized to guide appropriate selection based on different ...
Yinqi Tian, Yumeng Pan, Yingchun Zhang, Fangling Wang, Zejun Wang   +4 more
wiley   +1 more source

Research models to study lewy body dementia. [PDF]

Mol Neurodegener
Boschen SL, A Mukerjee A, H Faroqi A, E Rabichow B, Fryer J.   +4 more
europepmc   +1 more source

Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities

BMEMat, EarlyView.
This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan, Ye Zhu, Zhi Ye, Huayang Zhang, Junxi Wang, Guozhong Yi, Zhiyong Li, Rongyang Xu, Luyao Wang, Zhenzhen Wu, Songtao Qi, Guanglong Huang, Shanqiang Qu   +12 more
wiley   +1 more source