Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota
Scientific Reports, 2017 Alzheimer’s disease is the most common form of dementia in the western world, however there is no cure available for this devastating neurodegenerative disorder. Despite clinical and experimental evidence implicating the intestinal microbiota in a number
T. Harach +10 more
semanticscholar +1 more source
Reduced body weight and increased energy expenditure in transgenic mice over-expressing soluble leptin receptor. [PDF]
PLoS ONE, 2010 Soluble leptin receptor (OBRe), one of several leptin receptor isoforms, is the only bona fide leptin binding protein in plasma. Our earlier studies demonstrated that OBRe modulates leptin levels in circulation.
Phing-How Lou +7 more
doaj +1 more source
Functionalization and Characterization of Magnetic Nanoparticles for the Detection of Ferritin Accumulation in Alzheimer's Disease [PDF]
, 2018 Early diagnosis in Alzheimer's disease (AD), prior to the appearance of marked clinical symptoms, is critical to prevent irreversible neuronal damage and neural malfunction that lead to dementia and death.
Cussó, Lorena +4 more
core +1 more source
Human lymphoma mutations reveal CARD11 as the switch between self-antigen-induced B cell death or proliferation and autoantibody production [PDF]
, 2016 Self-tolerance and immunity are actively acquired in parallel through a poorly understood ability of antigen receptors to switch between signaling death or proliferation of antigenbinding lymphocytes in different contexts.
Domaschenz, Heather +8 more
core +1 more source
Functional Genomics for the Identification of Modulators of Platelet-Dependent Thrombus Formation
TH Open, 2018 Despite the absence of the genome in platelets, transcription profiling provides important insights into platelet function and can help clarify abnormalities in platelet disorders.
Elien Vermeersch +6 more
doaj +1 more source
Journal of Neuroscience, 2000 Amyloid plaques are a neuropathological hallmark of Alzheimer's disease (AD), but their relationship to neurodegeneration and dementia remains controversial.
L. Mucke +9 more
semanticscholar +1 more source
Antioxidant properties of HDL in transgenic mice overexpressing human apolipoprotein A-II
Journal of Lipid Research, 2002 Transgenic mice overexpressing human apolipoprotein A-II (huapoA-II) display high VLDL and low HDL levels. To evaluate the antioxidant potential of huapoA-II enriched HDL, we measured the activities of paraoxonase (PON) and platelet-activating factor ...
Elisabeth Boisfer +6 more
doaj +1 more source
Journal of Neuroinflammation, 2020 Background Tau hyper-phosphorylation has been considered a major contributor to neurodegeneration in Alzheimer’s disease (AD) and related tauopathies, and has gained prominence in therapeutic development for AD.
Yao Sun +13 more
doaj +1 more source
Factors Affecting Production Efficiency of Bacterial Artificial Chromosome Transgenic Mice
Shiyan dongwu yu bijiao yixue, 2021 ObjectiveBy comparing some key factors in generating bacterial artificial chromosome (BAC) transgenic mice, such as the background of strains, the concentration of the BAC DNA used for injection, the size of the BAC DNA, and the storage time of the BAC ...
WANG Qianqian +4 more
doaj +1 more source
TT2013 meeting report: the transgenic technology meeting visits Asia for the first time [PDF]
, 2013 The 11th Transgenic Technology meeting was held in Guangzhou, China on 25th–27th February 2013. Over 300 scientists and students from round the world gathered to hear the latest developments in the technologies underpinning the creation of transgenic and
Strathdee, D., Whitelaw, C.B.A.
core +3 more sources