Results 31 to 40 of about 3,684,237 (327)

Functionalization and Characterization of Magnetic Nanoparticles for the Detection of Ferritin Accumulation in Alzheimer's Disease [PDF]

, 2018
Early diagnosis in Alzheimer's disease (AD), prior to the appearance of marked clinical symptoms, is critical to prevent irreversible neuronal damage and neural malfunction that lead to dementia and death.
Cussó, Lorena, Desco, Manuel, Fernández Cabada, Tamara, Martínez Serrano, Alberto, Ramos Gómez, Milagros   +4 more
core   +1 more source

Application of transgenic mice to the molecular pathogenesis of cataract [PDF]

International Journal of Ophthalmology
One of the most prevalent disorders that cause blindness worldwide is cataract, and its essence is the visual disorder caused by the opacity of the lens. The significant degree of variation in cataracts and the fact that a variety of factors can impact a
Yue Zhang, Xiao-Ya Chen, Yu-Zhu Hu, Xiao Zhang, Shun-Fei Zheng, Shan-Shan Hu   +5 more
doaj   +1 more source

Generation of Fad2 and Fad3 transgenic mice that produce n-6 and n-3 polyunsaturated fatty acids [PDF]

Open Biology, 2019
Linoleic acid (18 : 2, n-6) and α-linolenic acid (18 : 3, n-3) are polyunsaturated fatty acids (PUFAs), which are essential for mammalian health, development and growth.
Lishuang Song, Lei Yang, Jiapeng Wang, Xuefei Liu, Lige Bai, Anqi Di, Guangpeng Li   +6 more
doaj   +1 more source

Galanin overexpressing transgenic mice [PDF]

Neuropeptides, 2002
Galanin overexpressing transgenic mice (GAL-tg) were generated on two different promoters. Both lines of GAL-tg displayed high levels of galanin in the hippocampus and reduced sensitivity to seizures, as compared to their respective wildtype littermate controls (WT).
Bartfai, Tamas, Hohmann, John G., Steiner, Robert A., Xu, Zhi-Qing D., Xu, Xiao-Jun, Holmberg, Kristina, Blakeman, Karin H., Hokfelt, Tomas, Mufson, Elliott J., Crawley, Jacqueline N., Wiesenfeld-Hallin, Zsuzsanna, Teklemichael, Dawit N.   +11 more
openaire   +2 more sources

Fecal microbiota transplantation alleviated Alzheimer’s disease-like pathogenesis in APP/PS1 transgenic mice

Translational Psychiatry, 2019
Alzheimer’s disease (AD) is the most common dementia in the elderly. Treatment for AD is still a difficult task in clinic. AD is associated with abnormal gut microbiota. However, little is known about the role of fecal microbiota transplantation (FMT) in
Jing Sun, Jingxuan Xu, Yi Ling, Fangyan Wang, Tianyu Gong, Changwei Yang, Shiqing Ye, Keyue Ye, Dianhui Wei, Ziqing Song, Danna Chen, Jiaming Liu   +11 more
semanticscholar   +1 more source

Reduced body weight and increased energy expenditure in transgenic mice over-expressing soluble leptin receptor. [PDF]

PLoS ONE, 2010
Soluble leptin receptor (OBRe), one of several leptin receptor isoforms, is the only bona fide leptin binding protein in plasma. Our earlier studies demonstrated that OBRe modulates leptin levels in circulation.
Phing-How Lou, Guoqing Yang, Lu Huang, Yunxia Cui, Tiffany Pourbahrami, George K Radda, Cai Li, Weiping Han   +7 more
doaj   +1 more source

Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota

Scientific Reports, 2017
Alzheimer’s disease is the most common form of dementia in the western world, however there is no cure available for this devastating neurodegenerative disorder. Despite clinical and experimental evidence implicating the intestinal microbiota in a number
T. Harach, N. Marungruang, N. Duthilleul, V. Cheatham, K. D. M. Coy, G. Frisoni, J. Neher, F. Fåk, M. Jucker, T. Lasser, T. Bolmont   +10 more
semanticscholar   +1 more source

Functional Genomics for the Identification of Modulators of Platelet-Dependent Thrombus Formation

TH Open, 2018
Despite the absence of the genome in platelets, transcription profiling provides important insights into platelet function and can help clarify abnormalities in platelet disorders.
Elien Vermeersch, Benedicte P. Nuyttens, Claudia Tersteeg, Katleen Broos, Simon F. De Meyer, Karen Vanhoorelbeke, Hans Deckmyn   +6 more
doaj   +1 more source

The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer’s disease

Journal of Neuroinflammation, 2020
Background Tau hyper-phosphorylation has been considered a major contributor to neurodegeneration in Alzheimer’s disease (AD) and related tauopathies, and has gained prominence in therapeutic development for AD.
Yao Sun, Yongqing Guo, Xuejian Feng, Meng Jia, Ning Ai, Yue Dong, Yayuan Zheng, Lu Fu, Bin Yu, Haihong Zhang, Jiaxin Wu, Xianghui Yu, Hui Wu, Wei Kong   +13 more
doaj   +1 more source

Factors Affecting Production Efficiency of Bacterial Artificial Chromosome Transgenic Mice

Shiyan dongwu yu bijiao yixue, 2021
ObjectiveBy comparing some key factors in generating bacterial artificial chromosome (BAC) transgenic mice, such as the background of strains, the concentration of the BAC DNA used for injection, the size of the BAC DNA, and the storage time of the BAC ...
WANG Qianqian, WANG Wei, LIU Rui, WEI Zhen, LIU Chong   +4 more
doaj   +1 more source