MMI‐0100 Inhibits Cardiac Fibrosis in a Mouse Model Overexpressing Cardiac Myosin Binding Protein C
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 BackgroundCardiac stress can trigger production of a 40‐kDa peptide fragment derived from the amino terminus of the cardiac myosin‐binding protein C.
Qinghang Meng +9 more
doaj +1 more source
Application of transgenic mice to the molecular pathogenesis of cataract [PDF]
International Journal of OphthalmologyOne of the most prevalent disorders that cause blindness worldwide is cataract, and its essence is the visual disorder caused by the opacity of the lens. The significant degree of variation in cataracts and the fact that a variety of factors can impact a
Yue Zhang +5 more
doaj +1 more source
Generation of Fad2 and Fad3 transgenic mice that produce n-6 and n-3 polyunsaturated fatty acids [PDF]
Open Biology, 2019 Linoleic acid (18 : 2, n-6) and α-linolenic acid (18 : 3, n-3) are polyunsaturated fatty acids (PUFAs), which are essential for mammalian health, development and growth.
Lishuang Song +6 more
doaj +1 more source
Neuronal Cell Type Classification using Deep Learning [PDF]
arXiv, 2023 The brain is likely the most complex organ, given the variety of functions it controls, the number of cells it comprises, and their corresponding diversity. Studying and identifying neurons, the brain's primary building blocks, is a crucial milestone and essential for understanding brain function in health and disease.
arxiv
Pain pathogenesis in rheumatoid arthritis -- what have we learned from animal models [PDF]
PAIN 2018 Sep; 159 Suppl:S98-S109, 2019 Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by joint inflammation and joint pain. Much of RA treatment is focused on suppressing inflammation, with the idea being that if inflammation is controlled other symptoms, such as pain, will disappear. However, pain is the most common complaint of RA patients, is often still present
arxiv +1 more source
Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota
Scientific Reports, 2017 Alzheimer’s disease is the most common form of dementia in the western world, however there is no cure available for this devastating neurodegenerative disorder. Despite clinical and experimental evidence implicating the intestinal microbiota in a number
T. Harach +10 more
semanticscholar +1 more source
Reduced body weight and increased energy expenditure in transgenic mice over-expressing soluble leptin receptor. [PDF]
PLoS ONE, 2010 Soluble leptin receptor (OBRe), one of several leptin receptor isoforms, is the only bona fide leptin binding protein in plasma. Our earlier studies demonstrated that OBRe modulates leptin levels in circulation.
Phing-How Lou +7 more
doaj +1 more source
Bayesian latent hierarchical model for transcriptomic meta-analysis to detect biomarkers with clustered meta-patterns of differential expression signals [PDF]
Ann Appl Stat. 2019 Mar 13(1), 2017 Due to the rapid development of high-throughput experimental techniques and fast-dropping prices, many transcriptomic datasets have been generated and accumulated in the public domain. Meta-analysis combining multiple transcriptomic studies can increase the statistical power to detect disease-related biomarkers.
arxiv +1 more source
Molecular Biology of the Cell, 2003 Macroautophagy mediates the bulk degradation of cytoplasmic components. It accounts for the degradation of most long-lived proteins: cytoplasmic constituents, including organelles, are sequestered into autophagosomes, which subsequently fuse with ...
N. Mizushima +4 more
semanticscholar +1 more source
Journal of Neuroinflammation, 2020 Background Tau hyper-phosphorylation has been considered a major contributor to neurodegeneration in Alzheimer’s disease (AD) and related tauopathies, and has gained prominence in therapeutic development for AD.
Yao Sun +13 more
doaj +1 more source