Results 111 to 120 of about 4,155,608 (362)

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Comprehensive mapping and modelling of the rice regulome landscape unveils the regulatory architecture underlying complex traits

Nature Communications
Unraveling the regulatory mechanisms that govern complex traits is pivotal for advancing crop improvement. Here we present a comprehensive regulome atlas for rice (Oryza sativa), charting the chromatin accessibility across 23 distinct tissues from three ...
Tao Zhu, Chunjiao Xia, Ranran Yu, Xinkai Zhou, Xingbing Xu, Lin Wang, Zhanxiang Zong, Junjiao Yang, Yinmeng Liu, Luchang Ming, Yuxin You, Dijun Chen, Weibo Xie   +12 more
doaj   +1 more source

Increasing values and worth of the Naga fireball tradition in Nong Khai Province: Creative learning of cultural tourism for international tourists. [PDF]

African Journal of Hospitality, Tourism and Leisure, 2019
The study has three major objectives. Firstly, it aims to study the local community participation in the conservation and preservation of the Naga Fireball tradition in Nong Khai Province.
Asst. Prof. Dr. Thirachaya Chaigassem, Patipat Tunming   +1 more
doaj  

Measures in Mice [PDF]

arXiv, 2013
This thesis analyses extenders in fine structural mice. Kunen showed that in the inner model for one measurable cardinal, there is a unique measure. This result is generalized, in various ways, to mice below a superstrong cardinal. The analysis is then used to show that certain tame mice satisfy $V=\mathsf{HOD}$. In particular, the approach proides a
arxiv  

Notes from data flow workshop [PDF]

, 2009
Copyright @ 2009 MICEThis document summarises the discussions at the MICE Data Flow Workshop held at Brunel University on 30th June 2009. Background information about job submission and file storage on the Grid can be found in previous MICE Notes and the
Nebrensky, JJ
core  

Palmoplantar keratoderma along with neuromuscular and metabolic phenotypes in Slurp1-deficient mice. [PDF]

, 2014
Mutations in SLURP1 cause mal de Meleda, a rare palmoplantar keratoderma (PPK). SLURP1 is a secreted protein that is expressed highly in keratinocytes but has also been identified elsewhere (e.g., spinal cord neurons).
Adeyo, Oludotun, Allan, Bernard B, Barnes, Richard H, Beigneux, Anne P, Fong, Loren G, Goulbourne, Chris N, Tatar, Angelica, Tontonoz, Peter, Tu, Yiping, Weinstein, Michael M, Young, Lorraine C, Young, Stephen G   +11 more
core   +2 more sources

Targeting rapid TKI‐induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia

Molecular Oncology, EarlyView.
Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale, Li Li, J. Kyle Bruner, Melody Chou, Bao Nguyen, Jaesung Seo, Ruiqi Zhu, Mark J. Levis, Christine A. Pratilas, Donald Small   +9 more
wiley   +1 more source

Evaluation of anti-inflammatory, anti-nociceptive, and anti-pyretic potential of hydroalcoholic extract of Trifolium pratense in mice

Complementary Medicine Journal of Faculty of Nursing and Midwifery, 2019
Introduction: There are some reports in traditional medicine concerning the anti-inflammatory, anti-nociceptive and anti-pyretic effects of Trifolium pretense (red clover).
Parandin R
doaj  

SIRT1 Is Necessary for Proficient Telomere Elongation and Genomic Stability of Induced Pluripotent Stem Cells

Stem Cell Reports, 2014
The NAD-dependent deacetylase SIRT1 is involved in chromatin silencing and genome stability. Elevated SIRT1 levels in embryonic stem cells also suggest a role for SIRT1 in pluripotency.
Maria Luigia De Bonis, Sagrario Ortega, Maria A. Blasco   +2 more
doaj   +1 more source

Progress on Cherenkov Reconstruction in MICE [PDF]

arXiv, 2016
Two beamline Cherenkov detectors (Ckov-a,-b) support particle identification in the MICE beamline. Electrons and high-momentum muons and pions can be identified with good efficiency. We report on the Ckov-a,-b performance in detecting pions and muons with MICE Step I data and derive an upper limit on the pion contamination in the standard MICE muon ...
arxiv