Results 161 to 170 of about 5,339,934 (354)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Inhibition of IDO leads to IL-6-dependent systemic inflammation in mice when combined with photodynamic therapy [PDF]

, 2020
Małgorzata Wachowska, Joanna Stachura, Katarzyna Tonecka, Klaudyna Fidyt, Agata Braniewska, Zuzanna Sas, Iwona Kotuła, Tomasz P. Rygiel, Louis Boon, Jakub Gołąb, Angelika Muchowicz   +10 more
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

PGE2‐EP3 signaling exacerbates hippocampus‐dependent cognitive impairment after laparotomy by reducing expression levels of hippocampal synaptic plasticity‐related proteins in aged mice [PDF]

, 2018
Jing‐Yu Xiao, Bingrui Xiong, Wen Zhang, Wenchang Zhou, Hui Yang, Feng Gao, Hong‐Bing Xiang, Anne Manyande, Xuebi Tian, Yuke Tian   +9 more
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Knockout Mice [PDF]

BioTechniques, 2013
openaire   +2 more sources

Biodistribution, pharmacokinetics, and blood compatibility of native and PEGylated tobacco mosaic virus nano-rods and -spheres in mice

, 2013
Michael A. Bruckman, Lauren N. Randolph, Allen VanMeter, Stephen Hern, Andrew J. Shoffstall, Rebecca E. Taurog, Nicole F. Steinmetz   +6 more
openalex   +2 more sources

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Analysis of the Correlation Between English Language Proficiency and the Professional Readiness of Students in Teacher Education Study Programs in Entering the Workforce

Jurnal Inovasi Pendidikan dan Sains
This study aims to analyze the correlation between English language proficiency and the professional readiness of students in teacher education study programs for entering the workforce. Students in teacher education study programs in Indonesia generally
Mella Narolita, Sri Rahayu
doaj  

Oxidative stress and inflammatory mediators contribute to endothelial dysfunction in high-fat diet-induced obesity in mice

, 2010
Renata Kobayasi, Eliana Hiromi Akamine, Ana Paula Davel, Maria Aparecida Marchesan Rodrigues, Carla Roberta de Oliveira Carvalho, Luciana Venturini Rossoni   +5 more
openalex   +1 more source