Results 181 to 190 of about 6,539,286 (354)

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Nature Cell Biology, 2014
J. Angeli, Manuela Schneider, B. Proneth, Y. Tyurina, V. Tyurin, V. Hammond, N. Herbach, M. Aichler, A. Walch, E. Eggenhofer, Devaraj Basavarajappa, O. Rådmark, Sho Kobayashi, Tobias Seibt, H. Beck, F. Neff, I. Esposito, R. Wanke, H. Förster, O. Yefremova, Marc Heinrichmeyer, G. Bornkamm, E. Geissler, Stephen B. Thomas, B. Stockwell, V. O’Donnell, V. Kagan, Joel A. Schick, M. Conrad   +28 more
semanticscholar   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Correction: TSG101 depletion dysregulates mitochondria and PML NBs, triggering MAD2-overexpressing interphase cell death (MOID) through AIFM1-PML-DAXX pathway

Cell Death and Disease
Yao Xi, Rui Xu, Shengnan Chen, Jiezhu Fang, Xiang Duan, Yidan Zhang, Guoli Zhong, Zhifei He, Yan Guo, Xinyu Li, Wenzhi Tao, Yang Li, Yan Li, Lei Fang, Yohei Niikura   +14 more
doaj   +1 more source

Synaptic Potentiation in Hippocampus by eEF2K Inhibitor A484954. [PDF]

Hippocampus
Yang Q, Li T, Jester HM, Su Q, Zhou X, Ryazanov AG, Ma T.   +6 more
europepmc   +1 more source

Running enhances neurogenesis, learning, and long-term potentiation in mice.

Proceedings of the National Academy of Sciences of the United States of America, 1999
H. V. Praag, B. Christie, T. Sejnowski, F. Gage   +3 more
semanticscholar   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Stress-Enhanced Fear Learning (SEFL) Is Associated With Enhanced Reactivation of Fear Engrams in Caudal But Not Rostral Dentate Gyrus. [PDF]

Hippocampus
Paredes D, Drew MR.
europepmc   +1 more source

Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation.

Cell, 1999
R. Chemelli, J. Willie, C. M. Sinton, J. Elmquist, T. Scammell, Charlotte E. Lee, James A. Richardson, S. Williams, Yumei Xiong, Y. Kisanuki, T. Fitch, M. Nakazato, Robert E. Hammer, C. B. Saper, M. Yanagisawa   +14 more
semanticscholar   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

IDH3A Deficiency Compromises Adaptive Thermogenesis and Exacerbates Obesity-Induced Metabolic Dysfunction via Impaired BCKDHA-Dependent BCAA Catabolism. [PDF]

Diabetes
Lu X, Bai N, Lyu J, Sun J, Su Y, Ye Y, Hu T, Liu T, Li W, Li X, Ma X, Yang Y, Bao Y.   +12 more
europepmc   +1 more source