Results 201 to 210 of about 2,583,516 (268)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Aging-Related Muscle Bmal1 Decline Contributes to Bone Loss in Mice via Enhancing IL-1α-Mediated Osteoclastogenesis. [PDF]

Aging Cell
Huang K, Qian J, Wang Y, Zhang F, Xu Y, Zhai Q.   +5 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Altered cognitive processes shape tactile perception in autism. [PDF]

Elife
Semelidou O, Tortochot-Megne Fotso M, Winderickx A, Frick AA.   +3 more
europepmc   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

GPR37 modulates body weight and insulin sensitivity in a sex-biased manner. [PDF]

PLoS One
Ahmed M, Santos MN, Abdelsayed K, Liu C, Xuseen N, Boakye PA, Owino S.   +6 more
europepmc   +1 more source

Oxytocin attenuates fear learning via enhancing somatostatin interneuron-mediated local GABAergic inhibition in the prelimbic cortex. [PDF]

Sci Adv
Xu H, Li Y, Cui X, Zhang Y, Wu X, Zhuo SS, He M, Xiao L.   +7 more
europepmc   +1 more source

Angiotensin II Induces Abdominal Aortic Branch Aneurysms in <i>Fibrillin-1^C1041G/+</i>Mice. [PDF]

Arterioscler Thromb Vasc Biol
Franklin MK, Howatt DA, Moorleghen JJ, Sheppard MB, Katsumata Y, Sawada H, Lu HS, Daugherty A.   +7 more
europepmc   +1 more source

Clustering Properties of Neuronal Ryanodine Receptor 2 and Remodeling in the APP/PS1 Mouse Model of Alzheimer's Disease. [PDF]

Acta Physiol (Oxf)
Munro ML, Silva RV, Ohline SM, Khaing EP, Chan JA, Ibrahim MF, Tausi TF, Abraham WC, Jones PP.   +8 more
europepmc   +1 more source