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Of Mice, Dirty Mice, and Men: Using Mice To Understand Human Immunology [PDF]
Abstract Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans. This review provides a brief summary of mouse natural history, husbandry, and the pros and cons of pursuing basic research in mice ...
Stephen C. Jameson+2 more
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Animal welfare concerns, reduced flight options and increased costs are pushing researchers to consider shipping frozen sperm and embryos rather than live mice.
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Rancangan Soal Geografi Menggunakan Taxonomy of Spatial Thinking Melalui Aplikasi Android
Geography learning outcomes need to be measured with an effective instrument to determine the achievement of learning outcomes. This study aims to produce a geographic question model that is developed using a taxonomy of spatial thinking.
Syahrul Ridha+3 more
doaj +1 more source
Particle swarm optimization with sequential niche technique for dynamic finite element model updating [PDF]
Peer ...
Abdel-Ghaffar+74 more
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Restless legs syndrome (RLS) is a neurological disorder that entails an urge to move with a circadian pattern during the evening/night. RLS may be accompanied by decreased sleep time and increased occurrence of periodic leg movements during sleep (PLMS),
Viviana Lo Martire+8 more
doaj +1 more source
The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL/MP-lpr/lpr mice [PDF]
MRL/MP-lpr/lpr (MRL/lpr) mice develop a spontaneous autoimmune disease. Serum from these mice contained significantly higher concentrations of nitrite/nitrate than serum from age-matched control MRL/MP-+/+ (MRL/+), BALB/c or CBA/6J mice.
Feng, G.J.+4 more
core +3 more sources
Transgenic mouse model faithfully reproduces human ovarian carcinoma and offers new opportunities for understanding the natural history of this frequently fatal disease.
openaire +3 more sources
The recent paper by Tang et al. (1999) describing the genetic enhancement of learning and memory in mice sparked a media frenzy that even a reclusive scientist could not avoid. For a brief period we were saturated by stories from newspapers, television, and radio reporting on these “smart” mice and the “IQ gene” and, inevitably, the possibility of ...
Edward B. Han, Charles F. Stevens
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Background Recent findings from studies of mouse models of Mendelian disorders of epigenetic machinery strongly support the potential for postnatal therapies to improve neurobehavioral and cognitive deficits. As several of these therapies move into human
Sarah Jessica Goodman+6 more
doaj +1 more source