Results 211 to 220 of about 6,887,725 (399)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Microglial VRK2 Regulates Astrocytic GABA Synthesis and Tonic Inhibition in the Thalamus. [PDF]

Glia
Lee D, Ha GE, Lee Y, Lee D, Lee J, Yoon JH, Chang L, Jo KW, Kwon HK, Kim KT, Cheong E.   +10 more
europepmc   +1 more source

Polysaccharides from Platycodon grandiflorus attenuates high-fat diet induced obesity in mice through targeting gut microbiota

, 2023
Weixin Ke, Kate J. Flay, Xiaoning Huang, Xiao Hu, Fang Chen, Chunbao Li, Danchen Aaron Yang   +6 more
openalex   +1 more source

Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice

Science, 2017
J. Fuster, Susan MacLauchlan, M. Zuriaga, Maya N. Polackal, Allison C. Ostriker, Raja Chakraborty, Chia-Ling Wu, S. Sano, S. Muralidharan, C. Rius, Jacqueline T Vuong, S. Jacob, Varsha Muralidhar, A. Robertson, M. Cooper, V. Andrés, K. Hirschi, K. Martin, K. Walsh   +18 more
semanticscholar   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Age-dependent removal of Atg9-containing vesicle accumulations in motoneuron disease models by physical exercise. [PDF]

Transl Neurodegener
Veh A, Ewald M, da Cruz Neris Geßner V, Giridhar NJ, Hutchings AJ, Stigloher C, Binotti B, Heinze KG, Lüningschrör P.   +8 more
europepmc   +1 more source

Nicotinamide mononucleotide alters mitochondrial dynamics by SIRT3‐dependent mechanism in male mice

, 2019
Nina Klimova, Aaron Long, Tibor Kristián   +2 more
openalex   +2 more sources

Running enhances neurogenesis, learning, and long-term potentiation in mice.

Proceedings of the National Academy of Sciences of the United States of America, 1999
H. V. Praag, B. Christie, T. Sejnowski, F. Gage   +3 more
semanticscholar   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Development of a floxed Gabbr2 gene allows for widespread conditional disruption of GABBR2 and recapitulates the phenotype of germline Gabbr2 knockout mice. [PDF]

PLoS One
Hens JR, Brown S, Licznerski P, Suarez J, Jonas E, Wysolmerski JJ.   +5 more
europepmc   +1 more source