Results 211 to 220 of about 5,339,934 (354)

LRP4+ Astrocytes: A Unique Subpopulation Crucial for Blood Vessel Maintenance and Function in the Somatosensory Cortex of Normal and 5xFAD Mice. [PDF]

Glia
Arzola E, Yu G, Xiong L, Lee D, Wu A, Paruchuri S, Skinner J, Wang M, Zhang B, Mei L, Xiong WC.   +10 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Social rank and social environment combinedly affect REM sleep in mice. [PDF]

Sci Rep
Hayashi N, Kawai A, Hayashi Y.
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Tau pathology reprograms glucose metabolism to support cortical hyperexcitability, excitatory/inhibitory imbalance, and sleep loss. [PDF]

NPJ Dement
Irmen RE, Turner SM, Snipes JA, Schloss KH, Wang X, Williams HC, Velmurugan GV, Hunt JB, Li J, Sullivan PG, Lee DC, Bauer AQ, Johnson LA, Macauley SL.   +13 more
europepmc   +1 more source

Gene expression profiling using DNA microarray analysis of the cerebellum of mice treated with methylmercury

, 2011
Gi‐Wook Hwang, Jin Yong Lee, Katsunori Ryoke, Fujio Matsuyama, Jong-Mu Kim, Tsutomu Takahashi, Akira Naganuma   +6 more
openalex   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Lipopolysaccharide induced mouse depression model can better simulate changes in peripheral blood FFAs in alMDD. [PDF]

PLoS One
Pan J, Liu G, Wang Y, Lan Y, Liang Y, Li W, Zhu K, Zhou Y, Ning Y.   +8 more
europepmc   +1 more source

A Phenotypic Analysis of Involucrin–Membrane-Bound Ovalbumin Mice after Adoptive Transfer of Ovalbumin-Specific CD8+ T Cells

, 2022
Yujin Nakagawa, Gyohei Egawa, T. Miyake, Saeko Nakajima, Atsushi Otsuka, Takashi Nomura, Akihiko Kitoh, Teruki Dainichi, Jun‐ichi Sakabe, Akihiko Shibaki, Y. Tokura, Tetsuya Honda, Kenji Kabashima   +12 more
openalex   +1 more source