Results 241 to 250 of about 6,817,423 (401)

Two‐way inhibition of PAX5 transcriptional activity by PAX5::CBFA2T3

open access: yesFEBS Open Bio, EarlyView.
PAX5::CBFA2T3 (PAX5‐C) is a fusion protein of the B‐cell transcription factor, PAX5, and is found in B‐cell ALL. We propose a putative model of two‐way inhibition of PAX5 transcriptional activity by PAX5‐C. There are two ways of repression by PAX5‐C: DNA‐binding‐dependent way and HDAC‐dependent way, with either being sufficient for the repression. HDAC
Reina Ueno   +12 more
wiley   +1 more source

GLUCOSE-6-PHOSPHATASE AND PHOSPHORYLASE ACTIVITIES IN MICE BEARING CORTICOTROPIN-SECRETING TUMORS

open access: hybrid, 1956
Kenneth H. Shull   +3 more
openalex   +1 more source

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

open access: yesFEBS Open Bio, EarlyView.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu   +12 more
wiley   +1 more source

The gut microbiota influences blood-brain barrier permeability in mice

open access: yesScience Translational Medicine, 2014
V. Braniste   +17 more
semanticscholar   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

open access: yesFEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr   +5 more
wiley   +1 more source

Deletion of C3G in hepatocytes impairs full liver maturation and alters glucose homeostasis. [PDF]

open access: yesCell Death Dis
Palao N   +11 more
europepmc   +1 more source

Ablation of progranulin augments microglial activation and accelerates prion progression. [PDF]

open access: yesActa Neuropathol Commun
Li B   +10 more
europepmc   +1 more source

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