Two‐way inhibition of PAX5 transcriptional activity by PAX5::CBFA2T3
PAX5::CBFA2T3 (PAX5‐C) is a fusion protein of the B‐cell transcription factor, PAX5, and is found in B‐cell ALL. We propose a putative model of two‐way inhibition of PAX5 transcriptional activity by PAX5‐C. There are two ways of repression by PAX5‐C: DNA‐binding‐dependent way and HDAC‐dependent way, with either being sufficient for the repression. HDAC
Reina Ueno+12 more
wiley +1 more source
LRRK2 deficiency mitigates amyloid β deposition-mediated pathology in a murine Alzheimer's disease model by reprogramming microglia. [PDF]
Zhang Q+7 more
europepmc +1 more source
GLUCOSE-6-PHOSPHATASE AND PHOSPHORYLASE ACTIVITIES IN MICE BEARING CORTICOTROPIN-SECRETING TUMORS
Kenneth H. Shull+3 more
openalex +1 more source
Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu+12 more
wiley +1 more source
Age and learning shapes sound representations in auditory cortex during adolescence. [PDF]
Praegel B+5 more
europepmc +1 more source
The gut microbiota influences blood-brain barrier permeability in mice
V. Braniste+17 more
semanticscholar +1 more source
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr+5 more
wiley +1 more source
Deletion of C3G in hepatocytes impairs full liver maturation and alters glucose homeostasis. [PDF]
Palao N+11 more
europepmc +1 more source
The Intracellular Metabolism of 3:4 Benzpyrene: Metabolism in the Kidneys and Skin of Rats and Mice [PDF]
G Calcutt
openalex +1 more source
Ablation of progranulin augments microglial activation and accelerates prion progression. [PDF]
Li B+10 more
europepmc +1 more source