Results 261 to 270 of about 6,539,286 (354)

Blockage of autophagy causes severe skeletal muscle disruption in a mouse model for myofibrillar myopathy 6. [PDF]

Nat Commun
Filippi K, Graf-Riesen K, Kuppusamy M, Unger A, Kimura K, Matijass M, Baeta H, Podlacha M, Haertter D, Kudin AP, Wiemann M, Węgrzyn G, Kornblum C, Reimann J, Linke WA, Huesgen PF, Kunz WS, Fleischmann BK, Hesse M.   +18 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

NDST3 suppression restores lysosomal acidification and ameliorates amyloid-β and MAPT/tau pathology in Alzheimer's disease. [PDF]

Transl Neurodegener
Ge C, Wang K, Tang H, Ke Y, Wang H, Fu Q, Xiu Y, Guo Y, Jia YF, Long Z, He G, Tang Q.   +11 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

GM-CSF orchestrates monocyte and granulocyte responses to Cryptococcus gattii. [PDF]

PLoS Pathog
Ricafrente A, Acharya S, Chen S, Abass A, Arshakyan A, Olson TJ, Trivedi A, Heung LJ.   +7 more
europepmc   +1 more source

Peripheral vaccination-induced brain-resident memory CD8+ T cells durably protect mice against intracranial malignancy. [PDF]

J Clin Invest
Mix MR, Sievers CM, Hassert M, Kannan SK, Pewe LL, Huang SC, He R, Fain CE, Heidarian M, Hancox LS, Arumugam SA, Beltz TG, Jin F, Johnson AJ, Carter CS, Butler NS, Salem AK, Badovinac VP, Harty JT.   +18 more
europepmc   +1 more source

Targeting Blimp-1 in T cells results in activation of T-bet-mediated control of immunosuppression in lung cancer. [PDF]

Cancer Immunol Immunother
Finotto S, Chiriac MT, Krammer S, Yang Z, Neurath L, Geppert CI, Nendel E, Trump S, Geiger A, Wirtz S, Zundler S, Neurath MF.   +11 more
europepmc   +1 more source

4-Phenylbutyrate mitigates renal pathology linked to ER stress related pathways in C57BL/6J mice with hindlimb unloading. [PDF]

Sci Rep
Ranade AV, Bernhardt GV, Jose J, Ramachandran G, Ebby S, Karim A, Ahmad F, Qaisar R, Gowda KMD.   +8 more
europepmc   +1 more source