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Altered ion permeability would clearly affect intercellular signaling and may precipitate the paroxysmal episodes. But how can a channelopathy generate a prolonged paroxysmal event? The episodic events observed in FHM/EA-2 and tottering/leaner generally last for tens of minutes to tens of hours; the shortest events, the spike and wave discharges ...
openaire +3 more sources
Echocardiography in Mice [PDF]
AbstractMurine models have been utilized with increasing frequency mainly due to availability of genetically engineered models. With advancement in high spatial and temporal resolution, echocardiography is used extensively for the evaluation of cardiovascular function in murine models of cardiovascular disease.
Dorothy E. Vatner+3 more
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Effects of Raw Ethanolic Seed Extract of Tetracarpidium conophorum on Heamatological and Histopathological Parameters in Swiss Albino Mice Infected with Plasmodium berghei [PDF]
Study was carried out to determine the heamatological and histopathological effects of raw ethanolic seed extract of Tetracarpidium conophorum in swiss albino mice infected with Plasmodium berghei (NK65).
D. A. Oloruntola+3 more
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Periprosthetic fracture around total knee arthroplasty (TKA) is a well-described complication. Yet, report of medial tibial plateau stress fracture after unicompartmental knee arthroplasty (UKA) is limited.
Hung Yuk-Wah+4 more
doaj +1 more source
Novel Omega-3 Fatty Acid Epoxygenase Metabolite Reduces Kidney Fibrosis. [PDF]
Cytochrome P450 (CYP) monooxygenases epoxidize the omega-3 polyunsaturated fatty acid (PUFA) docosahexaenoic acid into novel epoxydocosapentaenoic acids (EDPs) that have multiple biological actions.
Hammock, Bruce D+5 more
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Effect of FSH on testicular morphology and spermatogenesis in gonadotrophin-deficient hypogonadal mice lacking androgen receptors [PDF]
Follicle stimulating hormone (FSH) and androgen act to stimulate and maintain spermatogenesis. FSH acts directly on the Sertoli cells to stimulate germ cell number and acts indirectly to increase androgen production by the Leydig cells.
Abel, M.H.+4 more
core +2 more sources
PON2 Deficiency Leads to Increased Susceptibility to Diet-Induced Obesity. [PDF]
(1) Background: Paraoxonase 2 (PON2) is a ubiquitously expressed protein localized to endoplasmic reticulum and mitochondria. Previous studies have shown that PON2 exhibits anti-oxidant and anti-inflammatory functions, and PON2-deficient (PON2-def) mice ...
Fogelman, Alan M+9 more
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Hyperlipidemia is a chronic disease that seriously affects human health. Due to the fact that traditional animal models cannot fully mimic hyperlipidemia in humans, new animal models are urgently needed for basic drug research on hyperlipidemia. Previous
Xu Li+6 more
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An interleukin-33/ST2 signaling deficiency reduces overt pain-like behaviors in mice [PDF]
Interleukin (IL)-33, the most recent member of the IL family of cytokines, signals through the ST2 receptor. IL-33/ST2 signaling mediates antigen challenge-induced mechanical hyperalgesia in the joints and cutaneous tissues of immunized mice. The present
Alves-Filho, J.C.+9 more
core +3 more sources