Results 251 to 260 of about 206,641 (309)

Senomorphic Small Extracellular Vesicles Delivered by a Tissue‐Adhesive α‐Lipoic‐Acid Hydrogel Enable Immuno‐Rejuvenation for Bone‐Tendon Interface Regeneration

open access: yesAdvanced Science, EarlyView.
This work identifies M1 macrophage‐mediated inflammation as a key driver of BMSC senescence and bone microstructural deterioration at the enthesis. A tissue‐adhesive hydrogel delivering senomorphic small extracellular vesicles suppresses this inflammatory‐senescent cascade and enhances BMSC resilience by inhibiting the cGAS‐STING‐NF‐κB pathway.
Lingzhi Kong   +8 more
wiley   +1 more source

Micro-CT in drug delivery

European Journal of Pharmaceutics and Biopharmaceutics, 2010
Micro-computed tomography (micro-CT) has not to date been fully exploited in the area of controlled drug delivery despite its capability for providing detailed, 3-D images of morphology and the opportunity this presents for exploring the relationships between delivery device formulation, structure and performance.
Wang, Y.   +3 more
openaire   +3 more sources

Spectral optimization for micro‐CT

Medical Physics, 2012
Purpose:To optimize micro‐CT protocols with respect to x‐ray spectra and thereby reduce radiation dose at unimpaired image quality.Methods:Simulations were performed to assess image contrast, noise, and radiation dose for different imaging tasks. The figure of merit used to determine the optimal spectrum was the dose‐weighted contrast‐to‐noise ratio ...
Martin, Hupfer   +4 more
openaire   +2 more sources

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