Results 91 to 100 of about 14,460 (241)

The Evolution in Understanding the Physiological Causes of Dyspnoea in Large Hiatal Herniation: A Narrative Review

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background The symptomatology of large hiatus hernia (LHH) has been historically poorly understood, with cardiorespiratory symptoms caused by LHH being underappreciated by clinicians. This study reports on the mechanisms of dyspnoea in LHH through a historical review of symptoms and evolved physiological literature, discussing likely causation.
Arunan Mahendravarman, Fienne Cordeschi, Gregory Leighton Falk   +2 more
wiley   +1 more source

Direct evidence implicating the asymmetrical dimethylarginine (ADMA)‐dimethylarginine dimethylaminohydrolase 1 (DDAH1) pathway in cerebrovascular dysfunction and stroke pathogenesis in mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Asymmetrical dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS), whereas dimethylaminohydrolase 1 (DDAH1) is primarily responsible for its metabolism. However, the roles of DDAH1 in cerebrovascular regulation are poorly understood. Furthermore, despite evidence that elevated ADMA levels are
Arun Flynn, Alexandra Riddell, Ashton Bernard, Jennifer Haggarty, Stefan Weidt, Jawza Alenazi, Erika Trabold, Delyth Graham, Laura B. Dowsett, James Leiper, Alyson A. Miller   +10 more
wiley   +1 more source

Mitral regurgitation and decompensated heart failure in a young pregnant pony mare: An aetiological challenge

Equine Veterinary Education, EarlyView.
Summary A 4‐year‐old, 6‐month pregnant, Welsh pony mare presented with severe acute clinical signs including depression, anorexia, pale mucous membranes, tachycardia with a grade 4/6 holosystolic murmur and moderate expiratory dyspnoea with diffuse wheezes. There was no evidence of placentitis or fetal distress.
M. F. David, L. Cannon, A. Tortereau, A. Thomas‐Cancian, I. Desjardins   +4 more
wiley   +1 more source

European S2k guidelines for hidradenitis suppurativa/acne inversa Part 1. Epidemiology, diagnosis and clinical assessment

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Updated S2k hidradenitis suppurativa (HS) guidelines provide expert consensus on diagnosis, assessment and comorbidities. Expanded substantially since the 2015 version, they reflect rapid growth in HS literature and aim to improve generalist‐level patient care through evidence‐informed, consensus‐based guidance.
G. B. E. Jemec, B. Villumsen, K. R. van Straalen, H. H. van der Zee, S. Valiukevičienė, T. Tzellos, J. C. Szepietowski, A. Szegedi, D. M. L. Saunte, M. Romanelli, H. Raynal, F. Prignano, E. P. Prens, M. Podda, A. Nassif, A. Molina‐Leyva, Ł. Matusiak, A. V. Marzano, B. M. McGrath, A. I. Liakou, B. Kirby, L. Kemény, E. Just, D. Ioannidis, J. R. Ingram, R. E. Hunger, B. Horváth, P. Guillem, Ø. Grimstad, E. J. Giamarellos‐Bourboulis, M. Dolenc‐Voljč, V. Del Marmol, Z. Bukvić Mokos, V. Bettoli, F. Benhadou, F. G. Bechara, C. C. Zouboulis   +36 more
wiley   +1 more source

Cyclin‐dependent kinase 13 is indispensable for normal mouse heart development

Journal of Anatomy, Volume 246, Issue 4, Page 616-630, April 2025.
Congenital heart disease (CHD) is the most common defect in live births. The role of cyclin‐dependent kinase (CDK13) in cardiogenesis and CHD was studied using a transgenic mouse model (Cdk13tm1b) carrying deletion of exons 3 and 4, causing loss of function.
Qazi Waheed‐Ullah, Anna Wilsdon, Aseel Abbad, Sophie Rochette, Frances Bu'Lock, Asma Ali Saed, Marc‐Phillip Hitz, J. David Brook, Siobhan Loughna   +8 more
wiley   +1 more source

Fracture resistance and behavior of endodontically treated maxillary premolars with varying ferrule heights and post numbers: A laboratory study

Journal of Prosthodontics, EarlyView.
Abstract Purpose To investigate how varying ferrule heights and the number of glass fiber posts affect fracture resistance and behavior of endodontically treated maxillary first premolars with substantial loss of tooth structure. Materials and Methods Twenty‐four extracted endodontically treated human maxillary first premolars were divided into three ...
Mohammad D. Aljanakh, Fahad A. Bakitian, Sami A. Almohefer, Hatem D. Alshammari, Anmar Kensara, Ahmed A. Madfa   +5 more
wiley   +1 more source

Intermittent hypoxia increases lipid insulin resistance in healthy humans: A randomized crossover trial

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
This scheme illustrates the main results of the present study showing an increase in circulating free fatty acids (FFA) that are likely to be related to several mechanisms like decrease in FFA insulin sensitivity and increase in FFA production. Significant changes are labelled in white, and non‐significant or hypothesis are labelled in pale green ...
Anne Briançon‐Marjollet, Marie Netchitaïlo, Fanny Fabre, Elise Belaidi, Claire Arnaud, Anne‐Laure Borel, Patrick Levy, Jean‐Louis Pépin, Renaud Tamisier   +8 more
wiley   +1 more source

Cardiovascular Responses to Natural and Auditory Evoked Slow Waves Predict Post‐Sleep Cardiac Function

Journal of Sleep Research, EarlyView.
ABSTRACT The importance of sleep as a key component of cardiovascular health has been increasingly recognized. Our previous research demonstrated that auditory‐enhanced slow waves increase cardiac function, but the underlying mechanisms behind these beneficial effects remain uncertain. In this study, we examined the influence of two types of slow waves
Giulia Alessandrelli, Stephanie Huwiler, Giulio Bernardi, Manuel Carro‐Domínguez, Fabia Stich, Rossella Sala, Florent Aziri, Anna Trippel, Susanne Markendorf, David Niederseer, Philipp Bohm, Pietro Cerveri, Francesca Siclari, Reto Huber, Nicole Wenderoth, Christian Schmied, Caroline Lustenberger   +16 more
wiley   +1 more source

Safety and Stability of a Combined C2 Screw Placement Strategy With Vertebral Artery Mobilization

Orthopaedic Surgery, EarlyView.
An individualized C2 screw fixation strategy incorporating vertebral artery mobilization and atlantoaxial fusion cage support ensures safe, stable, and effective fixation in complex upper cervical anatomies, providing a reproducible approach for challenging craniovertebral junction reconstruction.
Peng Song, Shuangyin He, Tao Chen, Han Chen, Wenfu Yang, Xiyuan Tang, Tingting Xu, Xiaohong Yin, Bo Tan   +8 more
wiley   +1 more source

Three‐dimensional digital quantitative analysis of periodontal and peri‐implant phenotype—A narrative review

Periodontology 2000, EarlyView.
Abstract 3D digital evaluation of the periodontal and peri‐implant tissue, including CBCT, intraoral scanning, optical surface scanning, and ultrasonography, is being used in the clinical arena with increasing frequency. Thus, to validate the utilization of 3D digital analysis for this purpose, a critical evaluation of the reliability of digital ...
Yi Te Lin, Chenshuang Li, Jonathan Korostoff, Joseph P. Fiorellini, Jie Yang, Yu‐Cheng Chang   +5 more
wiley   +1 more source