Results 41 to 50 of about 234,016 (301)
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Generation of micro channels in AlMg4.5Mn0.7 sheets using a vibration-assisted micro forming process
MATEC Web of Conferences, 2018 Micro forming can be used for a highly efficient manufacturing of small parts like screws or caps. Because of the small dimensions of the structures, high stresses and forming forces occur, especially in the case of micro bulk forming.
Müller Benedikt, Schubert Andreas
doaj +1 more source
Microstructure Evolution and Material Flow of Steel in Semi-solid Forming Process [PDF]
, 2011 The present study aims to identify and characterize the development of microstructure and deformation characteristics of steel grades in semi-solid state which is affected by the change in morphologies of microstructure at high temperature ...
GU, Guochao +4 more
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
A new micro scale FE model of crystalline materials in micro forming process
MATEC Web of Conferences, 2016 Micro forming of metals has drawn global attention due to the increasing requirement of micro metal products. However, the size effects become significant in micro forming processes and affect the application of finite element (FE) simulation of micro ...
Luo Liang +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
EngIn the manufacturing of micro-scale components, geometric dimensional accuracy and product quality are critical factors that directly influence both production costs and efficiency.
Thu Nguyen Thi +2 more
doaj +1 more source
MATEC Web of Conferences, 2018 There is an increased demand for miniature/micro products (such as MEMS) and nanotechnology-based products (such as nano-materials). Micro-manufacturing is a link between Macro-and Nano Manufacturing and an effective means for transferring nanotechnology-
Hijji Hasan +4 more
doaj +1 more source
Convenient Form of Stand for Use as a Micro‐Colorimeter and with the Micro‐Spectroscope [PDF]
Journal of the Royal Microscopical Society, 1910 n ...
openaire +1 more source