Results 51 to 60 of about 234,016 (301)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Electrohydraulic incremental bulk metal forming
MATEC Web of Conferences, 2018 Electrohydraulic forming is a working media based high speed technique that is usually applied for sheet metal processing. In this process a shock wave acts as a flexible punch that transmits the punching force in a very short period of time.
Langstädtler Lasse +4 more
doaj +1 more source
Development and Measurement of 5 kN µ-Forming Machine
JEMMME (Journal of Energy, Mechanical, Material, and Manufacturing Engineering), 2016 The need of micro part become increasingly popular which make increase of the need of production technology with high accuracy, productivity, efficiency, and reliability. Metal forming technology offers the solution to answer the challenge.
Aida Mahmudah, Gandjar Kiswanto
doaj +1 more source
, 2020 Nowadays, there are increasing demand on micro-systems, micro products/components and micro-devices. Thus,the role of micro manufacturing in all aspects of modern industry is taken for granted. Then, typical processes inmicro manufacturing are discussed.
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Form measurements of micro-holes [PDF]
Measurement Science and Technology, 2007 The form measurement and gauge repeatability and reproducibility (R&R) of a micro-hole using a coordinate measurement machine (CMM) with a combination of optical and contact sensors were conducted in this study. The micro-holes, about 160 µm in diameter and 0.9 mm in depth, were fabricated using the electrical discharge machining process for diesel ...
Kao, Chen-Chun, Shih, Albert J.
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Nature CommunicationsAmorphous powder cores are promising components for next-generation power electronics. However, they present inherent challenges of internal air gaps and stresses during cold compaction, which significantly deteriorate soft magnetic properties.
H. Z. Li +11 more
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FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Research on the Micro-Extrusion Process of Copper T2 with Different Ultrasonic Vibration Modes
Metals, 2019 As an effective method for the fabrication of miniature metallic parts, the development of micro-forming process (MFP) is still restricted by the existence of size effect.
Linhong Xu +5 more
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FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source