Results 91 to 100 of about 695,874 (306)

Glycosylation Gene Signatures as Prognostic Biomarkers in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioblastoma (GBM) is an aggressive brain tumor characterized by significant heterogeneity. This study investigates the role of glycosylation‐related genes in GBM subtyping, prognosis, and response to therapy. Methods We analyzed mRNA expression data and clinical information from The Cancer Genome Atlas (TCGA) and Gene Expression ...
Tong Zhao, Hongliang Ge, Chenchao Lin, Xiyue Wu, Jianwu Chen   +4 more
wiley   +1 more source

Malignancy-Associated Regions of Transcriptional Activation: Gene Expression Profiling Identifies Common Chromosomal Regions of a Recurrent Transcriptional Activation in Human Prostate, Breast, Ovarian, and Colon Cancers

Neoplasia: An International Journal for Oncology Research, 2003
Despite remarkable advances in our understanding of a genetic basis of cancer, the precise molecular definition of the phenotypically relevant genetic features associated with human epithelial malignancies remains a significant and highly relevant ...
Gennadi V. Glinsky, Anja Krones-Herzig, Anna B. Glinskii   +2 more
doaj   +1 more source

Microarrays denoising via smoothing of coefficients in wavelet domain [PDF]

arXiv, 2018
We describe a novel method for removing noise (in wavelet domain) of unknown variance from microarrays. The method is based on a smoothing of the coefficients of the highest subbands. Specifically, we decompose the noisy microarray into wavelet subbands, apply smoothing within each highest subband, and reconstruct a microarray from the modified wavelet
arxiv  

Whole‐Blood RNA Sequencing Profiling of Patients With Rheumatoid Arthritis Treated With Tofacitinib

ACR Open Rheumatology, EarlyView.
Objective Patients with rheumatoid arthritis (RA) often fail to respond to therapies, including JAK inhibitors (JAKi), and treatment allocation is made via a trial‐and‐error strategy. A comprehensive analysis of responses to JAKi, including tofacitinib, by RNA sequencing (RNAseq) would allow the discovery of transcriptomic markers with a two‐fold ...
Chiara Bellocchi, Ennio Giulio Favalli, Gabriella Maioli, Elena Agape, Marzia Rossato, Matteo Paini, Adriana Severino, Barbara Vigone, Martina Biggioggero, Elena Trombetta, Roberto Caporali, Lorenzo Beretta   +11 more
wiley   +1 more source

Transcriptome Changes in Relation to Manic Episode

Frontiers in Psychiatry, 2019
Bipolar disorder (BD) is highly heritable and well known for its recurrent manic and depressive episodes. The present study focused on manic episode in BD patients and aimed to investigate state-specific transcriptome alterations between acute episode ...
Ya-Chin Lee, Yu-Lin Chao, Chiao-Erh Chang, Ming-Hsien Hsieh, Kuan-Ting Liu, Hsi-Chung Chen, Mong-Liang Lu, Mong-Liang Lu, Wen-Yin Chen, Chun-Hsin Chen, Chun-Hsin Chen, Mong-Hsun Tsai, Tzu-Pin Lu, Ming-Chyi Huang, Ming-Chyi Huang, Po-Hsiu Kuo, Po-Hsiu Kuo   +16 more
doaj   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Techniques for clustering gene expression data [PDF]

, 2007
Many clustering techniques have been proposed for the analysis of gene expression data obtained from microarray experiments. However, choice of suitable method(s) for a given experimental dataset is not straightforward. Common approaches do not translate
Crane, Martin, Doolan, Padraig, Kerr, Gráinne, Ruskin, Heather J.   +3 more
core   +3 more sources

Overview of Microarray Analysis of Gene Expression and its Applications to Cervical Cancer Investigation

Taiwanese Journal of Obstetrics & Gynecology, 2007
Cervical cancer is one of the leading female cancers in Taiwan and ranks as the fifth cause of cancer death in the female population. Human papillomavirus has been established as the causative agent for cervical neoplasia and cervical cancer.
Angel Chao, Tzu-Hao Wang, Chyong-Huey Lai   +2 more
doaj   +1 more source

Microarray Data Management. An Enterprise Information Approach: Implementations and Challenges [PDF]

arXiv, 2006
The extraction of information form high-throughput experiments is a key aspect of modern biology. Early in the development of microarray technology, researchers recognized that the size of the datasets and the limitations of both computational and visualization techniques restricted their ability to find the biological meaning hidden in the data.
arxiv  

Nucleic acid - protein fingerprints. Novel protein classification based on nucleic acid - protein recognition [PDF]

, 2012
Protein chemistry uses protein description and classification based on molecular mass and isoelectric point as general features. Enzymes are also compared by enzymatic reaction constants, namely Km and kcat values. Proteins are also studied by binding to
Alexander Krylov, Renad Zhdanov
core   +1 more source