Results 211 to 220 of about 515,000 (271)

DNA Molecular Computing with Weighted Signal Amplification for Cancer miRNA Biomarker Diagnostics

Advanced Science, EarlyView.
A molecular computing approach is presented with weighted signal amplification. Polymerase‐mediated strand displacement is employed to assign weights to target miRNAs, reflecting the miRNAs’ diagnostic values, followed by amplification of the weighted signals using localized DNA catalytic hairpin assembly.
Hongyang Zhao, Yumin Yan, Linghao Zhang, Xin Li, Lan Jia, Liang Ma, Xin Su   +6 more
wiley   +1 more source

A tumor-binding antibody with cross-reactivity to viral antigens. [PDF]

Cancer Immunol Immunother
Campa MJ, Gottlin EB, Wiehe K, Patz EF.
europepmc   +1 more source

Halofuginone Disrupted Collagen Deposition via mTOR‐eIF2α‐ATF4 Axis to Enhance Chemosensitivity in Ovarian Cancer

Advanced Science, EarlyView.
COL1A1, a major component of ECM, contributes to chemoresistance and poor prognosis in ovarian cancer. Halofuginone (HF) attenuates CAF‐secreted COL1A1 through mTOR‐eIF2α‐ATF4 axis. Notably, HF disrupts collagen deposition to form the looser ECM and facilitates CD8+ T cell infiltration, partially via M2‐M1 macrophage polarization to enhance ...
Wenxin Li, Yenan Wu, Yanan Zhang, Wenyan Gao, Xin Li, Haixia Luo, Mengmeng Lu, Zhihua Liu, Aiping Luo   +8 more
wiley   +1 more source

Novel Detection and Clinical Utility of Serum-Derived Extracellular Vesicle in Angiosarcoma. [PDF]

Acta Derm Venereol
Yokoi K, Wang J, Yoshioka Y, Fujisawa Y, Fujimoto M, Ochiya T, Tanemura A.   +6 more
europepmc   +1 more source

ALKBH3‐Mediated M1A Demethylation of METTL3 Endows Pathological Fibrosis:Interplay Between M1A and M6A RNA Methylation

Advanced Science, EarlyView.
RNA modification is crucial in fibrosis diseases, but the role of m1A modification remains elusive. This study reveals that ALKBH3, an m1A demethylase, drives skin fibrosis by reshaping m6A RNA modification and stabilizing COL1A1 and FN1 mRNAs through METTL3, uncovering a crosstalk between m1A and m6A methylation in pathological events.
Liying Tu, Shuchen Gu, Ruoqing Xu, En Yang, Xin Huang, Hsin Liang, Shenying Luo, Haizhou Li, Yixuan Zhao, Tao Zan   +9 more
wiley   +1 more source

Omalizumab Treated Urticaria Patients Display T Cell and Thrombocyte-Associated Gene Regulation. [PDF]

Immun Inflamm Dis
Smola A, Hawerkamp HC, Oláh P, Kislat A, Duschner N, Homey B, Meller S.   +6 more
europepmc   +1 more source

Plac1+ Tumor Cell‐Treg Interplay Supports Tumorigenesis and Progression of Head and Neck Cancer

Advanced Science, EarlyView.
Meng et al. screen genes in the CTAs family and find Plac1 is specifically expressed in head and neck squamous cell carcinoma (HNSCC) cells. They reveal that Plac1 expression promotes HNSCC progression directly by activating PI3K/AKT signaling pathway.
Xiaoyan Meng, Zhonglong Liu, Lu Zhao, Ran Li, Luoman Gan, Liren Cao, Jingjing Sun, Lingfang Zhang, Yue He   +8 more
wiley   +1 more source

Development and application of a cGPS 20K liquid-phase SNP microarray in Jiaji ducks. [PDF]

Poult Sci
Xu T, Xu Z, Bai D, Wu F, Shang Y, Li M, Rong G, Gu L.   +7 more
europepmc   +1 more source

Microarray data analysis: from disarray to consolidation and consensus

Nature reviews genetics, 2006
D. Allison, X. Cui, G. Page, M. Sabripour   +3 more
semanticscholar   +1 more source

Distinct CTC Specific RNA Profile Enables NSCLC Early Detection and Dynamic Monitoring of Advanced NSCLC

Advanced Science, EarlyView.
A quantitative CTC RNA assay is developed by incorporating multi‐antibody‐based CTC isolation and specific mRNA quantification using RT‐ddPCR. The NSCLC CTC ScoreD demonstrates high accuracy for early‐stage NSCLC detection, significantly outperforming serum CEA. NSCLC CTC ScoreM exhibits a more accurate early‐warning of responses to different therapies
Xiaoyu Wang, Pi Ding, Wenjuan Xu, Lei Qiu, Jing Ren, Yucheng Fei, Zhili Wang, Cheng Li, Yufei Xing, Mingjing Shen, Yawen Zhu, Yun Guo, Na Sun, Renjun Pei, Minhua Shi   +14 more
wiley   +1 more source