Results 221 to 230 of about 349,535 (265)
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2007
Gene expression microarrays are being used widely to address a myriad of complex biological questions. To gather meaningful expression data, it is crucial to have a firm understanding of the steps involved in the application of microarrays. The available microarray platforms are discussed along with their advantages and disadvantages.
Norman H, Lee, Alexander I, Saeed
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Gene expression microarrays are being used widely to address a myriad of complex biological questions. To gather meaningful expression data, it is crucial to have a firm understanding of the steps involved in the application of microarrays. The available microarray platforms are discussed along with their advantages and disadvantages.
Norman H, Lee, Alexander I, Saeed
openaire +2 more sources
2009
Gene expression analysis has progressed rapidly over the past decade from the historical analyses of individual genes to the sophisticated genome surveys routinely performed today. DNA biochips have facilitated this progression and helped accelerate target validation and drug discovery efforts by the pharmaceutical industry.
Ubaldi, Massimo +6 more
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Gene expression analysis has progressed rapidly over the past decade from the historical analyses of individual genes to the sophisticated genome surveys routinely performed today. DNA biochips have facilitated this progression and helped accelerate target validation and drug discovery efforts by the pharmaceutical industry.
Ubaldi, Massimo +6 more
openaire +4 more sources
Immunohistochemistry Microarrays
Analytical Chemistry, 2017Immunohistochemistry (IHC) on tissue sections is widely used for quantifying the expression patterns of proteins and is part of the standard of care for cancer diagnosis and prognosis, but is limited to staining a single protein per tissue. Tissue microarray and microfluidics staining methods have emerged as powerful high throughput techniques, but ...
Huiyan Li +5 more
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Zeitschrift für Rheumatologie, 2011
Since their development in the 1990s DNA microarrays have advanced to one of the most important technologies for biomedical research. Miniaturization enables up to 1 million different sequence-specific DNA hybridization tests to be performed on an area of less than 2 cm². Depending on the selection of oligonucleotide sequences, which are assembled on a
R, Biesen, T, Häupl
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Since their development in the 1990s DNA microarrays have advanced to one of the most important technologies for biomedical research. Miniaturization enables up to 1 million different sequence-specific DNA hybridization tests to be performed on an area of less than 2 cm². Depending on the selection of oligonucleotide sequences, which are assembled on a
R, Biesen, T, Häupl
openaire +2 more sources
Current Protocols in Protein Science, 2005
AbstractWith the introduction of DNA microarrays as novel analytical tools, the determination of thousands of binding events in one reaction became possible. The developed technology platforms are not limited to nucleic acids, and, in principle, every ligand‐binding assay that works on solid phase can be miniaturized and brought into an array format ...
Stefan, Kramer +2 more
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AbstractWith the introduction of DNA microarrays as novel analytical tools, the determination of thousands of binding events in one reaction became possible. The developed technology platforms are not limited to nucleic acids, and, in principle, every ligand‐binding assay that works on solid phase can be miniaturized and brought into an array format ...
Stefan, Kramer +2 more
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Microarrays in Pharmacogenomics
Journal of Biopharmaceutical Statistics, 2004DNA array technology provides tools for studying the expression profiles of a large number of distinct genes simultaneously.
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2008
High throughput methodologies have increased by several orders of magnitude the amount of experimental microarray data available. Nevertheless, translating these data into useful biological knowledge remains a challenge. There is a risk of perceiving these methodologies as mere factories that produce never-ending quantities of data if a proper ...
Dopazo J, Al-Shahrour F
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High throughput methodologies have increased by several orders of magnitude the amount of experimental microarray data available. Nevertheless, translating these data into useful biological knowledge remains a challenge. There is a risk of perceiving these methodologies as mere factories that produce never-ending quantities of data if a proper ...
Dopazo J, Al-Shahrour F
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MCN: The American Journal of Maternal/Child Nursing, 2016
Abstract Over the last half century, knowledge about genetics, genetic testing, and its complexity has flourished. Completion of the Human Genome Project provided a foundation upon which the accuracy of genetics, genomics, and integration of bioinformatics knowledge and testing has grown exponentially. What is lagging, however, are efforts to
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Abstract Over the last half century, knowledge about genetics, genetic testing, and its complexity has flourished. Completion of the Human Genome Project provided a foundation upon which the accuracy of genetics, genomics, and integration of bioinformatics knowledge and testing has grown exponentially. What is lagging, however, are efforts to
openaire +4 more sources
Cold Spring Harbor Protocols, 2019
Most laboratories will choose to order microarrays from a commercial vendor; however, microarray printing is sufficiently straightforward that even small laboratories with extensive microarray needs may find it cost-effective and worth the effort to produce their own microarrays. Printing microarrays requires a spotting robot.
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Most laboratories will choose to order microarrays from a commercial vendor; however, microarray printing is sufficiently straightforward that even small laboratories with extensive microarray needs may find it cost-effective and worth the effort to produce their own microarrays. Printing microarrays requires a spotting robot.
openaire +2 more sources
2010
Bioinformatics has become an increasingly important tool for molecular biologists, especially for the analysis of microarray data. Microarrays can produce vast amounts of information requiring a series of consecutive analyses to render the data interpretable.
Robert P, Loewe, Peter J, Nelson
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Bioinformatics has become an increasingly important tool for molecular biologists, especially for the analysis of microarray data. Microarrays can produce vast amounts of information requiring a series of consecutive analyses to render the data interpretable.
Robert P, Loewe, Peter J, Nelson
openaire +2 more sources