Results 211 to 220 of about 493,696 (293)

Early Screening for Cervical Squamous Cell Carcinoma and Precancerous Lesions Based on Surface-Enhanced Raman Spectroscopy Microarray Chips. [PDF]

Int J Nanomedicine
Xia J, Sun J, Lu D.
europepmc   +1 more source

A Suspected Mosaic 3q29 Deletion in a Patient With Autism Spectrum Disorder and Multiple Micronutrient Deficiencies: A Case Report. [PDF]

Case Rep Genet
Yatsuga S.
europepmc   +1 more source

Modulation of Animal Gut Health by Milk Oligosaccharide

Animal Research and One Health, EarlyView.
This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen, Nana Jing, Shiyu Tao, Mingyue Fei, Wentao Lv, Hua Yang, Yingping Xiao, Haiqin Wu   +7 more
wiley   +1 more source

A Common Small-Molecule Inhibitor Targeting Multiple Siglecs Associated with Immune Checkpoint Suppression of Cytotoxicity and Phagocytosis. [PDF]

J Am Chem Soc
Chung C, Li R, Cheng LC, Fan CY, Liao KS, Kung CC, Wong CH.   +6 more
europepmc   +1 more source

The Nuclear Receptor Testicular Receptor 4 Orchestrates Cytoskeletal Organization in a G Protein Subunit Alpha 12/Rho‐Associated Protein Kinase–Dependent Manner to Promote Myofibroblast Differentiation and Tissue Fibrosis in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective Members of the superfamily of nuclear receptors have been implicated in inflammatory processes and pathologic tissue remodeling and have emerged as attractive targets for pharmaceutical intervention. However, the role of testicular receptor 4 (TR4; or Nr2c2) in fibroblast activation and rheumatologic diseases has not yet been investigated ...
Yun Zhang, Lichong Shen, Junhui Zheng, Gisela Baur, Dilidaer Yasen, Honglin Zhu, Yi‐Nan Li, Xianyi Meng, Thuong Trinh‐Minh, Tim Filla, Debomita Chakraborty, Andrea‐Hermina Györfi, Christina Bergmann, Adam Reich, Alexander Kreuter, Georg Schett, Jörg H. W. Distler   +16 more
wiley   +1 more source

Chromosome Microarray Analysis of 3832 Patients over 15 Years Confirms Genome-Wide Copy Number Variation in Patients with Developmental Disabilities Including Autism. [PDF]

Curr Issues Mol Biol
Chaval S, Tonk SS, Wilson GN, Tonk VS.
europepmc   +1 more source

Distinct Molecular Pathways Supporting Sjögren Disease Clusters and Disease Progression

Arthritis &Rheumatology, EarlyView.
Objective Sjögren disease (SjD) is a heterogeneous autoimmune disease. We aimed to investigate blood transcriptomic signatures and disease progression among three recently defined clusters of patients with SjD: (1) B cell active disease with low symptom burden (BALS), (2) high systemic activity (HSA), and (3) low systemic activity with high symptom ...
Sacha E. Silva‐Saffar, Yann Nguyen, Raphaèle Seror, Jacques‐Eric Gottenberg, Anna Niarakis, Xavier Mariette, Gaetane Nocturne   +6 more
wiley   +1 more source

Comprehensive Characterization of Cytochrome P450s Reveals Candidate Enzymes Involved in the Metabolic Fate of Absorbed Volatile Organic Compounds in Potato. [PDF]

Antioxidants (Basel)
Bogdanović MD, Devrnja N, Ćuković Janićijević KB, Stupar S, Todorović SI, Savić J.   +5 more
europepmc   +1 more source

MDL‐800‐induced SIRT6 activation decreases age‐associated osteoarthritis in mice

Arthritis &Rheumatology, Accepted Article.
Objective SIRT6 is a nuclear‐localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL‐800, decreases the severity of age‐associated osteoarthritis (OA) in mice.
Matheus Moreira Perez, Pranay Ramteke, Bahiyah Watson, Owen Haslam, Eirene Choi, Susan Chubinskaya, Mandy J. Peffers, William R. Davis, Jacqueline Shine, Brian O. Diekman, Richard F. Loeser, Theresa A. Freeman, Makarand V. Risbud, John A. Collins   +13 more
wiley   +1 more source

Integrated Immune Profiling Identifies Treatment-Associated Immune Patterns in Patients with B-Cell Hematological Malignancies. [PDF]

J Proteome Res
Arias-Hidalgo C, Hernández-Vazquez J, Teodosio C, Juanes-Velasco P, Nuño-Soriano A, Cal-Sabater P, Arribas-Rodríguez E, Fiz-López A, Pérez-Mazzali M, Martín-Muñoz Á, Tellería P, Vicuña MG, Gamazo-Herrero J, Fuente-Graciani I, Pérez-González S, Bravo S, García-Alonso C, Dueñas C, Peñarrubia MJ, Vigo-Aceves M, Núñez-Abascal C, Neira-González L, Gongora R, Cuesta-Sancho S, Bernardo D, Hernández ÁP, Fuentes M.   +26 more
europepmc   +1 more source