Results 221 to 230 of about 544,008 (293)

SNORA58 Facilitates Radioresistance via Suppressing JNK1‐Mediated Ferroptosis in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
In ESCC patients, SNORA58 exhibits heterogeneous expression patterns. Its aberrant overexpression stabilizes CTCF by inhibiting ubiquitin‐mediated degradation, leading to the attenuation of JNK1‐mediated ferroptosis induced by radiotherapy through disruption of intracellular iron homeostasis, and ultimately contributes to radioresistance ...
Yinli Zheng, Fangyi Liu, Yuhua Huang, Yanfen Feng, Xia Yang, Jinjun Wu, Xin Yang, Xuanhao Lin, Lives Jiang, Tingting Zeng, Yan Li, Xinyuan Guan, Yuanyuan Wang, Chunyan Chen, Jingping Yun   +14 more
wiley   +1 more source

Ultrasound and genetic findings in a case series of fetuses presenting vertebral defects. [PDF]

BMC Pregnancy Childbirth
Xie W, Zhou L, Hu A, Chen J, Pang J, Xi H, Luo Y, Hu J, Yang S, Gao X, Kuang H, Tang W, Liu R, Wang S, Peng Y.   +14 more
europepmc   +1 more source

Clathrin Light Chain B Drives Hepatocellular Carcinoma Progression Through Dual Mechanisms: Small Extracellular Vesicle‐Mediated Angiogenesis and the NF‐κB–PCLAF Signaling Axis

Advanced Science, EarlyView.
Clathrin Light Chain B (CLTB) drives hepatocellular carcinoma progression through dual pathways: intracellularly, it activates the NF‐κB–PCLAF axis to enhance small extracellular vesicle (sEV) uptake and tumor proliferation; extracellularly, CLTB‐enriched sEVs bind SH3KBP1 to inhibit its degradation, inducing angiogenesis and vascular leakage ...
Xiaoke Sun, Junchen Guo, Ning Zhao, Guanghua Cui, Yun Bai, Meijuan Ding, Yi Xu, Yu Yang   +7 more
wiley   +1 more source

Phase Determination and Demonstration of Parental Mosaicism of Intragenic <i>PRKN</i> Deletions Initially Identified by Chromosomal Microarray Analysis. [PDF]

Genes (Basel)
Choate LA, Hoffman F, Newman JH, Runke C, Webley M, Hoppman NL, Thorland EC.   +6 more
europepmc   +1 more source

ASH2L‐K312‐Lac Stimulates Angiogenesis in Tumors to Expedite the Malignant Progression of Hepatocellular Carcinoma

Advanced Science, EarlyView.
In this study, ASH2L‐K312‐lac is identified as a critical driver that promotes the malignant progression of hepatocellular carcinoma (HCC). Furthermore, through a comprehensive series of cell biological and molecular biological experiments, integrated with diverse animal models and systematic application of high‐throughput sequencing technologies, it ...
Hexu Han, Shuai Wang, Lixing Ma, Haimeng Yin, Xinxiang Cheng, YiFan Wang, Suqin Xia, Yi Zhang, Yue Zhang, Rong Zhu, Cuixia Liu, Dakun Zhao, Xiangqian Gu, He Zhu, Yin Yuan   +14 more
wiley   +1 more source

Dengue virus modulates critical cell cycle regulatory proteins in human megakaryocyte cells. [PDF]

Sci Rep
Basak S, Dutta S, Khanal S, Neelakanta G, Sultana H.   +4 more
europepmc   +1 more source

Polycystin‐1 Mutant Alters Mechanotransduction in Response to Collagen and Extracellular Matrix Stiffness via Daam1‐Dependent Microfilament Remodeling

Advanced Science, EarlyView.
Polycystin‐1 (PC1) senses collagen and ECM stiffness to promote tumor migration via Daam1‐mediated actin remodeling. A cleavage‐resistant PC1 mutant enhances YAP nuclear translocation and CTGF expression, which activates CAFs and further stiffens the ECM, forming a feed‐forward loop that drives tumor progression and metastasis.
Jiaofeng Zhou, Yibing Deng, Jie Mei, Mengyun Wan, Ningyi Xue, Xinyu Zong, Ji Zhou, Junli Ding, Ting Yan, Yu Jiang, Tiansong Xia, Peng Zheng, Yichao Zhu   +12 more
wiley   +1 more source

Usutu Virus Antibody Dynamics in Naturally Infected Blackbirds, the Netherlands, 2016-2018. [PDF]

Emerg Infect Dis
de Bruin E, van Irsel J, Chandler F, Kohl R, van de Voorde T, van der Linden A, de Boer F, Koopmans M, van der Jeugd H, Reusken C.   +9 more
europepmc   +1 more source

Hypoxia‐Induced PRMT1 Lactylation Drives Vimentin Arginine Asymmetric Dimethylation in Tumor Metastasis

Advanced Science, EarlyView.
Hypoxia triggers lactylation of PRMT1 at K134/K145, enhancing its methyltransferase activity to asymmetrically dimethylate vimentin R64. This post‐translational cascade promotes vimentin filament assembly, cytoskeletal remodeling, and tumor metastasis, with PRMT1 inhibition (MS023) reducing metastatic colonization.
Jia Zhou, Shuying Qiu, Xia Yang, Yan Wu, Xinxia Yao, Hangqi Hu, Jingfeng Luo, Chandra Sugiarto Wijaya, Lingfeng Ma, Xiaojun Long, Lingna Xu, Jinquan Liu, Chaoqun Wang, Yibin Pan, Xiaona Chen, Hongchuan Jin, Xian Wang   +16 more
wiley   +1 more source