Results 81 to 90 of about 907,938 (379)

Beyond Microarrays [PDF]

Science Signaling, 2008
Studies of global changes in mRNA abundance may be less than insightful.
openaire   +2 more sources

Protein Microarrays [PDF]

, 2009
Protein microarrays containing nearly the entire yeast proteome have been constructed. They are typically prepared by overexpression and high-throughput purification and printing onto microscope slides. The arrays can be used to screen nearly the entire proteome in an unbiased fashion and have enormous utility for a variety of applications.
Fasolo, Joseph, Snyder, Michael
openaire   +2 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Over-Expression of OsHOX24 Confers Enhanced Susceptibility to Abiotic Stresses in Transgenic Rice via Modulating Stress-Responsive Gene Expression

Frontiers in Plant Science, 2017
Homeobox transcription factors play critical roles in plant development and abiotic stress responses. In the present study, we raised rice transgenics over-expressing stress-responsive OsHOX24 gene (rice homeodomain-leucine zipper I sub-family member ...
Mukesh Jain, Mukesh Jain, Annapurna Bhattacharjee, Raghvendra Sharma   +3 more
doaj   +1 more source

The Reproducibility of Lists of Differentially Expressed Genes in Microarray Studies [PDF]

, 2007
Reproducibility is a fundamental requirement in scientific experiments and clinical contexts. Recent publications raise concerns about the reliability of microarray technology because of the apparent lack of agreement between lists of differentially ...
Brett Thorn, Catalin C. Barbacioru, Cecilie Boysen, Charles Wang, Damir Herman, Ernest S. Kawasaki, Federico M. Goodsaid, Felix W. Frueh, Feng Qian, Hong Fang, Hongmei Sun, Huixiao Hong, James C. Fuscoe, James C. Willey, James J. Chen, Janet A. Warrington, Jie Wu, Jing Han, Lei Guo, Leming Shi, Liang Zhang, Lisa J. Croner, Lu Zhang, Nan Mei, Patrick J. Collins, Qian Xie, Quan-Zhen Li, Raj K. Puri, Richard Shippy, Roderick V. Jensen, Roger G. Perkins, Ron L. Peterson, Russell D. Wolfinger, Shashi Amur, Sheng Zhong, Stephen C. Harris, Sue-Jane Wang, Tzu-Ming Chu, Vincent Bertholet, Weida Tong, Wendell D. Jones, Wenjun Bao, Xiao-hui Fan, Xiaoxi Megan Cao, Xu Guo, Yaron Turpaz, Yongming Andrew Sun, Yuling Luo, Yunqing Ma, Zhenqiang Su   +49 more
core   +2 more sources

Comparison of RNA-Seq and Microarray Gene Expression Platforms for the Toxicogenomic Evaluation of Liver From Short-Term Rat Toxicity Studies

Frontiers in Genetics, 2019
Gene expression profiling is a useful tool to predict and interrogate mechanisms of toxicity. RNA-Seq technology has emerged as an attractive alternative to traditional microarray platforms for conducting transcriptional profiling.
Mohan S. Rao, T. V. Van Vleet, R. Ciurlionis, W. Buck, S. Mittelstadt, E. Blomme, M. Liguori   +6 more
semanticscholar   +1 more source

INF2‐Related Charcot–Marie–Tooth Disease in a Japanese Cohort: Genetic and Clinical Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background INF2 mutations cause focal segmental glomerulosclerosis (FSGS) and Charcot–Marie–Tooth disease (CMT). Accurate genetic diagnosis is critical, as INF2‐related FSGS is typically resistant to immunotherapy yet rarely recurs after transplantation, and its associated neuropathy can mimic treatable immune‐mediated disorders such as ...
Chikashi Yano, Masahiro Ando, Yujiro Higuchi, Jun‐Hui Yuan, Akiko Yoshimura, Takahiro Hobara, Risa Nagatomo, Fumikazu Kojima, Yu Hiramatsu, Satoshi Nozuma, Tomonori Nakamura, Yusuke Sakiyama, Chika Matsuoka, Toru Yamashita, Takashi Kimura, Ayako Miyazaki, Chinatsu Kinjo, Kenji Yokochi, Nanami Yamanaka, Nozomu Matsuda, Tomoki Suichi, Yoshiyuki Hanaoka, Haruka Kojima, Kenichi Todo, Hiroyuki Ishiura, Jun Mitsui, Shoji Tsuji, Hiroshi Takashima   +27 more
wiley   +1 more source

Predictors of primary breast cancers responsiveness to preoperative Epirubicin/Cyclophosphamide-based chemotherapy: translation of microarray data into clinically useful predictive signatures

Journal of Translational Medicine, 2005
Background Our goal was to identify gene signatures predictive of response to preoperative systemic chemotherapy (PST) with epirubicin/cyclophosphamide (EC) in patients with primary breast cancer.
Munnes Marc, Prisack Hans-Bernd, Modlich Olga, Audretsch Werner, Bojar Hans   +4 more
doaj   +1 more source

Can Zipf's law be adapted to normalize microarrays? [PDF]

, 2005
BACKGROUND: Normalization is the process of removing non-biological sources of variation between array experiments. Recent investigations of data in gene expression databases for varying organisms and tissues have shown that the majority of expressed ...
Costello, Christine M, Croucher, Peter JP, Deuschl, Günther, Häsler, Robert, Lu, Tim, Schreiber, Stefan   +5 more
core   +3 more sources

A Survey on Hybrid Feature Selection Methods in Microarray Gene Expression Data for Cancer Classification

IEEE Access, 2019
The emergence of DNA Microarray technology has enabled researchers to analyze the expression level of thousands of genes simultaneously. The Microarray data analysis is the process of finding the most informative genes as well as remove redundant and ...
Nada Almugren, Hala M. Alshamlan
semanticscholar   +1 more source