Results 141 to 150 of about 837,577 (343)

N6-methyladenosine methylation analysis of circRNAs in acquired middle ear cholesteatoma

Frontiers in Genetics
IntroductionMiddle ear cholesteatoma is a chronic middle ear disease characterized by severe hearing loss and adjacent bone erosion, resulting in numerous complications.
Jun He, Ahmad Mahmoudi, Jacqueline Yao, Qiulin Yuan, Jinfeng Fu, Wei Liu   +5 more
doaj   +1 more source

Knowledge-based analysis of microarray gene expression data by using support vector machines [PDF]

, 2000
Michael P. Brown, William Noble Grundy, David Lin, Nello Cristianini, Charles W. Sugnet, Terrence S. Furey, Manuel Ares, David Haussler   +7 more
openalex   +1 more source

Isoquercitrin Alleviates Diabetic Nephropathy by Inhibiting STAT3 Phosphorylation and Dimerization

Advanced Science, EarlyView.
This study identified a natural compound, isoquercitrin, which significantly alleviated kidney inflammation and fibrosis by inhibiting STAT3 activity. Isoquercitrin forms a strong, noncovalent bond that directly binds to STAT3. Isoquercitrin binds to the pY+1 pocket of the SH2 domain of STAT3 via hydrogen bonding with Ser668, Gln635, and Gln633 ...
Chen Xuan, Donghui Chen, Shuangna Zhang, Chaofan Li, Qingyun Fang, Dinghua Chen, Jiabao Liu, Xin Jiang, Yingjie Zhang, Wanjun Shen, Guangyan Cai, Xiangmei Chen, Ping Li   +12 more
wiley   +1 more source

Global Analysis of Herpes Simplex Virus Type 1 Transcription Using an Oligonucleotide-Based DNA Microarray [PDF]

, 2000
S. W. Stingley, José Javier García‐Ramírez, Santiago Aguilar, Kenneth Simmen, Rozanne M. Sandri-Goldin, Peter Ghazal, E K Wagner   +6 more
openalex   +1 more source

BAG2 Inhibits Cervical Cancer Progression by Modulating Type I Interferon Signaling through Stabilizing STING

Advanced Science, EarlyView.
Based on IP‐MS analysis, BAG2 is confirmed to be essential for ubiquitination and protein homeostasis regulation of STING in cervical cancer. BAG2 inhibits the ubiquitination and degradation of STING by forming a complex with STUB1, thereby activating the type I IFN signaling pathway and inhibiting the development of cervical cancer.
Shijie Yao, Siming Chen, Anjin Wang, Ziyan Liang, Xuelian Liu, Yang Gao, Hongbing Cai   +6 more
wiley   +1 more source

Microarray analysis of the transcriptional network controlled by the photoreceptor homeobox gene Crx [PDF]

, 2000
Frederick J. Livesey, Takahisa Furukawa, Martín Steffen, George M. Church, Constance L. Cepko   +4 more
openalex   +1 more source

CircTP53/USP10/p53 signaling Axis as a Novel Regulator of Progression and Prognosis of Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
The study identifies a novel circular RNA derived from the TP53 gene (circTP53), which is upregulated in HNSCC and correlates with poor patient prognosis. It demonstrates that circTP53 promotes HNSCC progression by interacting with USP10, stabilizing both proteins, enhancing deubiquitination of p53, and thereby influencing tumor growth, with its ...
Yin Wang, Fen Chang, Zinan Li, Chengcheng Duan, Xiangkai Sun, Siyu Wang, Dongmin Wei, Wenming Li, Ye Qian, Shengda Cao, Juan Zhao, Dapeng Lei   +11 more
wiley   +1 more source

Gene Expression Analysis of the Streptococcus pneumoniae Competence Regulons by Use of DNA Microarrays [PDF]

, 2000
Scott N. Peterson, Robin T. Cline, Hervé Tettelin, Vasily Sharov, Donald A. Morrison   +4 more
openalex   +1 more source

Activation of HTR2B Suppresses Osteosarcoma Progression through the STAT1‐NLRP3 Inflammasome Pathway and Promotes OASL1+ Macrophage Production to Enhance Antitumor Immunity

Advanced Science, EarlyView.
Activation of HTR2B suppresses osteosarcoma progression through the STAT1‐NLRP3 inflammasome pathway and promotes OASL1+ Macrophage production to enhance anti‐tumor immunity. Abstract Osteosarcoma is a primary malignant bone tumor originating from mesenchymal tissue, and associated with poor prognosis.
Zhen Huang, Jiazhuang Zhu, Jianping Hu, Xingkai Wang, Xiaolong Ma, Enjie Xu, Kunpeng Zhu, Chunlin Zhang   +7 more
wiley   +1 more source

Genome microarray analysis of transcriptional activation in multidrug resistance yeast mutants [PDF]

, 2000
Joseph L. DeRisi, Bart van den Hazel, Philippe Marc, Elisabetta Balzi, Patrick O. Brown, Claude Jacq, André Goffeau   +6 more
openalex   +1 more source