Results 121 to 130 of about 19,288,705 (257)
Advanced Science, EarlyView.ABSTRACT Gastric cancer (GC) is a major global health concern, as its prevention and treatment remain significant challenges. The 8‐oxoguanine (o8G) modification of circRNAs, alongside their capacity to orchestrate liquid‐liquid phase separation (LLPS) and autophagy, plays a pivotal role in driving tumor progression and determining therapeutic outcomes.
Lei Peng +8 more
wiley +1 more source
Analysis on Microarray Data and DNA Regulatory Elements Prediction
, 2002 Transcription profiling with microarray technology has significantly accelerated our understanding of complex biological processes by allowing the genome-wide measure of message RNA levels.
Lu, Jun
core
Statistical analysis of microarrays [PDF]
, 2005 Microarray statistical analysis involves thousands of hypothesis tests to consider at the same time. Empirical Bayes methods which are well-suited for large scale inference problems seem to be the most appropriate approach for microarray data.
Mouzaki, Daphne
core
Advanced Science, EarlyView.Through integrated proteomic and metabolomic profiling, Zhao et al. identified three molecular subtypes of high‐grade serous ovarian cancer. The high‐risk subtype exhibits activated arachidonic acid metabolism and cyclooxygenase‐2 overexpression. This metabolic axis promotes M2‐like macrophage infiltration, which contributes to platinum resistance ...
Yuxi Zhao +11 more
wiley +1 more source
EMMA2 : a MAGE-compliant system for the analysis of microarray data in integrated functional genomics [PDF]
, 2007 Dondrup M. EMMA2 : a MAGE-compliant system for the analysis of microarray data in integrated functional genomics. Bielefeld (Germany): Bielefeld University; 2007.Since the acquisition of the first complete genomic sequences, many advances have been made ...
Dondrup, Michael
core
Advanced Science, EarlyView.Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu +11 more
wiley +1 more source
Advanced Science, EarlyView.In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu +12 more
wiley +1 more source
CALB2 is a Mechanoresistance Gene in Metastatic Prostate Cancer
Advanced Science, EarlyView.Prostate cancer cell lines of differing origins were cultured over many passages while being subjected to semi‐lethal levels of fluid shear stress, representing the harsh mechanical environment these cells are subjected to in the circulation during the process of distant metastasis.
Abigail R. Fabiano +10 more
wiley +1 more source
Сибирский онкологический журнал, 2016 This study presents the new evidences for DNA Copy Number Aberration (CNA) within breast tumors and its association with the efficacy of preoperative (neoadjuvant) chemotherapy.Methods.
N. V. Litviakov +9 more
doaj
Advanced Science, EarlyView.This study established a high‐quality organoid biobank derived from 68 tumor sites across 50 Chinese patients, elucidated the drug sensitivity‐based molecular subtyping in breast cancer, and revealed a novel mechanism of drug resistance mediated by the FAK‐ACSL1 pathway.
Hao Xu +10 more
wiley +1 more source