Results 181 to 190 of about 180,353 (259)

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

Pico-Scale Digital PCR on a Super-Hydrophilic Microarray Chip for Multi-Target Detection. [PDF]

Micromachines (Basel)
Xian Q, Zhang J, Wong YC, Gao Y, Song Q, Xu N, Wen W.   +6 more
europepmc   +1 more source

Outcome of IWGT workshop on transcriptomic biomarkers for genotoxicity: Key considerations for bioinformatics

Environmental and Molecular Mutagenesis, EarlyView.
Abstract As a part of the International Workshop on Genotoxicity Testing (IWGT) in 2022, a workgroup was formed to evaluate the level of validation and regulatory acceptance of transcriptomic biomarkers that identify genotoxic substances. Several such biomarkers have been developed using various molecular techniques and computational approaches. Within
Matthew J. Meier, Florian Caiment, J. Christopher Corton, Roland Frötschl, Yurika Fujita, Danyel Jennen, Roman Mezencev, Carole Yauk   +7 more
wiley   +1 more source

Consensus findings of an International Workshops on Genotoxicity Testing workshop on using transcriptomic biomarkers to predict genotoxicity

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Gene expression biomarkers have the potential to identify genotoxic and non‐genotoxic carcinogens, providing opportunities for integrated testing and reducing animal use. In August 2022, an International Workshops on Genotoxicity Testing (IWGT) workshop was held to critically review current methods to identify genotoxicants using ...
Roland Froetschl, J. Christopher Corton, Henghong Li, Jiri Aubrecht, Scott S. Auerbach, Florian Caiment, Tatyana Y. Doktorova, Yurika Fujita, Danyel Jennen, Naoki Koyama, Matthew J. Meier, Roman Mezencev, Leslie Recio, Takayoshi Suzuki, Carole L. Yauk   +14 more
wiley   +1 more source

A systematic review and meta-analysis of the diagnostic accuracy after preimplantation genetic testing for aneuploidy. [PDF]

PLoS One
Bacal V, Li A, Shapiro H, Rana U, Zwingerman R, Avery L, Palermo A, Philipoppolous E, Chan C.   +8 more
europepmc   +1 more source

Review of Transcriptomic Biomarkers That Predict In Vitro Genotoxicity in Human Cell Lines

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The current genotoxicity testing paradigm provides little mechanistic information, has poor specificity in predicting carcinogenicity in humans, and is not suited to assessing a large number of chemicals. Genomic technologies enable the characterization of genome‐wide transcriptional changes in response to chemical treatments that can inform ...
Heng‐Hong Li, Jiri Aubrecht, Tatyana Y. Doktorova, Danyel Jennen, J. Christopher Corton, Roland Froetschl, Roman Mezencev, Carole L. Yauk   +7 more
wiley   +1 more source

The Chicken Egg Genotoxicity Assay (CEGA): Assessing Target Tissue Exposure and Metabolism in the Embryo‐Fetal Chicken Livers

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The Chicken Egg Genotoxicity Assay (CEGA) is an avian egg‐based model that utilizes the livers of developing chicken embryo‐fetuses to assess the ability of chemicals to produce direct DNA damage. The main goal of the study was to evaluate target tissue exposure and metabolism in the CEGA to assess its suitability as a biologically relevant ...
Yax Thakkar, T. Kobets, Anne Marie Api, J. D. Duan, G. M. Williams   +4 more
wiley   +1 more source

Exploring the association between serotonin transporter promoter region methylation levels and depressive symptoms: a systematic review and multi-level meta-analysis. [PDF]

Transl Psychiatry
Javelle F, Dao G, Ringleb M, Pulverer W, Bloch W.   +4 more
europepmc   +1 more source

ILAE neuroimaging task force highlight: MRI detection of early life epilepsy caused by focal cortical dysplasia

Epileptic Disorders, EarlyView.
Abstract The ILAE Neuroimaging Task Force aims to publish educational case reports that highlight basic aspects of neuroimaging in epilepsy consistent with the ILAE's educational mission. Here, we describe a case series of three neonates with focal cortical dysplasia (FCD)‐related drug‐resistant epilepsy who underwent surgical intervention. The purpose
Nathan T. Cohen, L. Gilbert Vezina, Chima Oluigbo, Tayyba Anwar, John Archer, Boris C. Bernhardt, Lorenzo Caciagli, Fernando Cendes, Yotin Chinvarun, Luis Concha, Paolo Federico, Eliane Kobayashi, Godwin Ogbole, Stefan Rampp, Anna Elisabetta Vaudano, Z. Irene Wang, Shuang Wang, Gavin P. Winston, William D. Gaillard   +18 more
wiley   +1 more source

BAMBI integrates biostatistical and artificial intelligence methods to improve RNA biomarker discovery. [PDF]

Brief Bioinform
Zhou P, Li Z, Liu F, Kwon E, Hsieh TC, Ye S, Vasudevan S, Lee JA, Tran KV, Zhou C.   +9 more
europepmc   +1 more source