Results 231 to 240 of about 185,542 (303)

Autoantibody profiling using microarray identifies biomarkers associated with chemoimmunotherapy efficacy and immune-related adverse events in lung cancer patients. [PDF]

Clin Exp Med
Wang Z, Yu B, Guo S, Chen Q, Zhang X, Zhang R, Fan Y, Lv J, Dong Y, Niu Q, Zhang X, Liu Y, Chen L, Wu Y, Xu X, Liu R, Jiao Y, Hu D, Jia Y, Wang B, Cao Z, Tan Q, Yu X.   +22 more
europepmc   +1 more source

Targeting SPHK1 in macrophages remodels the tumor microenvironment and enhances anti‐PD‐1 immunotherapy efficacy in colorectal cancer liver metastasis

Cancer Communications, EarlyView.
Abstract Background Colorectal cancer liver metastasis (CRLM) is characterized by an immunosuppressive microenvironment and a blunted response to immunotherapy. Notably, tumor‐associated macrophages (TAMs) play a critical role in modulating immune responses and exhibit significant heterogeneity in CRLM.
Yizhi Zhan, Jinsong Xu, Zhanqiao Zhang, Yating Hu, Yongsheng Li, Junying Qian, Yunyan Ling, Dehua Wu, Haijun Deng, Guoxin Li, Zhiyong Shen, Yuan Fang   +11 more
wiley   +1 more source

Two‐Color Timestamping of Gene Expression with a Chemigenetic Reporter System

ChemBioChem, EarlyView.
A chemigenetic reporter assay is developed that enables monitoring of BiP/GRP78 expression, an important chaperone and key regulator of the unfolded protein response. The system is based on the coexpression of BiP/GRP78 and the self‐labeling protein HaloTag.
Henriette Lämmermann, Jade Nguyen, Juan F. Tamez‐Fernández, Fabien Kuttler, Julien Bortoli Chapalay, Marc Chambon, Gerardo Turcatti, Pablo Rivera‐Fuentes   +7 more
wiley   +1 more source

Cancer classification in high dimensional microarray gene expressions by feature selection using eagle prey optimization. [PDF]

Front Genet
Dhamercherla S, Reddy Edla D, Dara S.
europepmc   +1 more source

CALR Type 1‐Like Mutations Increase Endoplasmic Reticulum Free Ca2+ and Induce ERK1/2 Activation Independent of Thrombopoietin Receptor Activation

Cell Biology International, EarlyView.
ABSTRACT Calreticulin is a multifunctional protein found in the endoplasmic reticulum lumen that is important for calcium homeostasis and glycoprotein folding. Mutations in exon 9 of the CALR gene are the second most common genetic cause of myeloproliferative neoplasms.
Mifra Faiz, Caitlin Dunstan‐Harrison, Elizabeth C. Ledgerwood   +2 more
wiley   +1 more source

Enhanced leukemia prediction using hybrid ant colony and ant lion optimization for gene selection and classification. [PDF]

MethodsX
D S, Rajaram G, R E, J V, I G, J R.
europepmc   +1 more source

Quantum Osteoimmunology: A Paradigm Shift in Understanding and Influencing Bone–Immune Crosstalk

ChemMedChem, EarlyView.
This article introduces quantum osteoimmunology as a novel field exploring how quantum phenomena may shape immune–skeletal signaling. This approach could help resolve longstanding questions in osteoimmune physiology and pathology. It also highlights the potential of quantum nanomaterials for ultrasensitive diagnostics and precision‐targeted ...
Rachel Wei Li, Sara Alzaanin, Zongyou Yin, Paul N. Smith   +3 more
wiley   +1 more source

Disclosing the development and focus of sequencing and omics studies in kidney neoplasm research. [PDF]

Discov Oncol
Liu Y, Lu B, Yang X, Cui J, Yang T, Zhang H, Zhao Z, Lyu D, Li Y, Yao Y, Huang R, Pan X.   +11 more
europepmc   +1 more source

Harnessing Synergies between Combinatorial Microfluidics and Machine Learning for Chemistry, Biology, and Fluidic Design

Chemistry–Methods, EarlyView.
This review explores the synergy of combinatorial microfluidics and machine learning, highlighting their transformative impact on high‐throughput experimentation, closed‐loop reaction optimization, and autonomous platform development. Key applications in chemical synthesis, biological research, and microfluidic design are discussed, addressing ...
Suyash S. Damir, Julie Probst, Andrew deMello, Stavros Stavrakis   +3 more
wiley   +1 more source