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Comparison of different probe-level analysis techniques for oligonucleotide microarrays
Three different software packages for the probe-level analysis of high-density oligonucleotide microarray data were compared using an experiment-derived data set that was validated using real-time PCR. The efficiency with which these three programs could identify true positives in this data set was assessed. In addition, estimates of false-positive and
Samantha Rodriguez+4 more
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Knowledge-based gene expression classification via matrix factorization [PDF]
Motivation: Modern machine learning methods based on matrix decomposition techniques, like independent component analysis (ICA) or non-negative matrix factorization (NMF), provide new and efficient analysis tools which are currently explored to analyze ...
A. M. Tomé+47 more
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Bioinformatics Techniques in Microarray Research: Applied Microarray Data Analysis Using R and SAS Software [PDF]
Exploration of the underlying biological mechanisms of disease is useful for many purposes such as the development of novel treatment modalities in addition to informing on-going risk factor research. DNA-microarray technology is a relatively recent and novel approach to conducting genome-wide gene expression studies to identify previously unknown ...
Ryan T. Demmer+2 more
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Improved processing of microarray data using image reconstruction techniques [PDF]
Spotted cDNA microarray data analysis suffers from various problems such as noise from a variety of sources, missing data, inconsistency, and, of course, the presence of outliers.
Liu, X.+2 more
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Can Zipf's law be adapted to normalize microarrays? [PDF]
BACKGROUND: Normalization is the process of removing non-biological sources of variation between array experiments. Recent investigations of data in gene expression databases for varying organisms and tissues have shown that the majority of expressed ...
Costello, Christine M+5 more
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Evaluation of the Tissue Microarray Technique for Immunohistochemical Analysis in Rectal Cancer
Abstract Background.—Immunohistochemical staining for tumor-associated proteins is widely used for the identification of novel prognostic markers. Recently, a tissue-conserving, high-throughput technique, tissue microarray, has been introduced. This technique uses 0.6-mm tissue core biopsy specimens, 500 to 1000 of which are brought into
Michael Dictor+4 more
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Aptamer Microarrays-Current Status and Future Prospects [PDF]
Microarray technologies are state of the art in biological research, which requires fast genome, proteome and transcriptome analysis technologies. Often antibodies are applied in protein microarrays as proteomic tools.
Stahl, Frank+2 more
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Examining the uses of shared data [PDF]
Background Many initiatives and repositories exist to encourage the sharing of research data, and thousands of microarray gene expression datasets are publicly available.
Douglas Fridsma+2 more
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The scope of this paper is to illustrate the need for an improved quality assurance in fluorometry. For this purpose, instrumental sources of error and their influences on the reliability and comparability of fluorescence data are highlighted for ...
Ebert, P.+7 more
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Gene expression analysis of glucocorticoid-induced apoptosis by a gene microarray technique [PDF]
Gene expression analysis of glucocorticoid-induced apoptosis by a gene microarray ...
Michael H. Malone+3 more
openaire +1 more source