Results 51 to 60 of about 134,878 (263)
A 17 Year Old With Developmental Delay Presenting With Increasing Confusion and Imbalance
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Methylmalonic acidemia is an autosomal recessive genetic disorder primarily caused by defects in methylmalonyl‐CoA mutase and cobalamin (vitamin B12) metabolism. These defects disrupt the tricarboxylic acid cycle and oxidative phosphorylation, leading to the abnormal accumulation of metabolic products such as methylmalonic acid, propionic acid,
Wei Zhao, Yingli Zhang, Hongliang Zheng
wiley +1 more source
Advanced Healthcare Materials, EarlyView.A miniaturized drug sensitivity and resistance testing (DSRT) workflow based on the Droplet Microarray (DMA) platform enables functional drug testing using minimal patient‐derived tumor material. By screening nanoliter‐scale droplets containing as few as 300 cells, this approach generates reproducible and tumor‐specific drug response profiles ...
Maryam Salarian +7 more
wiley +1 more source
Network‐based classification of breast cancer metastasis
Molecular Systems Biology, 2007 Mapping the pathways that give rise to metastasis is one of the key challenges of breast cancer research. Recently, several large‐scale studies have shed light on this problem through analysis of gene expression profiles to identify markers correlated ...
Han‐Yu Chuang +4 more
doaj +1 more source
Microarraying for Mechanosensivitity [PDF]
Cell Stem Cell, 2010 In a recent issue of Science, Gilbert et al. combine biomaterial microarrays with lineage tracking to demonstrate that muscle stem cell survival is sensitive to the microenvironment's mechanical stiffness (Gilbert et al., 2010). This work enhances the breadth and depth of knowledge in stem cell mechanobiology.
openaire +2 more sources
Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy
Advanced Healthcare Materials, EarlyView.Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima +15 more
wiley +1 more source
Microarray Analysis of Gene Expression of Cancer to Guide the Use of Chemotherapeutics
Taiwanese Journal of Obstetrics & Gynecology, 2007 The beauty of microarray analysis of gene expression (MAGE) is that it can be used to discover some genes that were previously thought to be unrelated to a physiologic or pathologic event.
Tzu-Hao Wang, Angel Chao
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Microgel‐based 3D printed constructs represent a compelling and versatile innovation for engineering architecturally complex, dynamically remodelable, and biocompatible structures with high structural fidelity and bioactivity. By integrating material design, biofabrication, and biological function, these systems enable the development of adaptive ...
Elena Ghighină +2 more
wiley +1 more source
Genome-Wide Transcriptional Responses of Mycobacterium to Antibiotics
Frontiers in Microbiology, 2019 Antibiotics can stimulate or depress gene expression in bacteria. The analysis of transcriptional responses of Mycobacterium to antimycobacterial compounds has improved our understanding of the mode of action of various drug classes and the efficacy and ...
Julien Briffotaux +5 more
doaj +1 more source
Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy
Advanced Materials, EarlyView.Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa +3 more
wiley +1 more source
Frontiers in Plant Science, 2017 Grafting of elite cultivars onto tolerant rootstocks is an advanced strategy to increase tomato tolerance to sub-optimal temperature. However, a detailed understanding of adaptive mechanisms to sub-optimal temperature in rootstocks and scions of grafting
Georgia Ntatsi +7 more
doaj +1 more source