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Infectious diseases continue to plague the modern world. In the evolutionary arms race of pathogen emergence, the rules of engagement appear to have suddenly changed. Human activities have collided with nature to hasten the emergence of more potent pathogens from natural microbial populations. This is evident in recent infectious disease outbreaks, the
Mahan, Michael J +2 more
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Interplay between host-microbe and microbe-microbe interactions in cystic fibrosis
The respiratory tract of individuals with cystic fibrosis is host to polymicrobial infections that persist for decades and lead to significant morbidity and mortality. Improving our understanding of CF respiratory infections requires coordinated efforts from researchers in the fields of microbial physiology, genomics, and ecology, as well as epithelial
Catherine R. Armbruster +3 more
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Microbes Evolve, Microbes Survive [PDF]
T Hugh Pennington President, Society for General Microbiology, Emeritus Professor of Bacteriology, University of Aberdeen, Medical School Building, Foresterhill, Aberdeen, AB25 2ZD, UK Tel.: +44 122 453 104; Fax: +44 122 455 2692; mmb036@abdn.ac.uk ‘I believe that microbiologists, and all biologists, should do everything in their power to improve the ...
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Tabanids as possible pathogen vectors in Senegal (West Africa)
Background Species of the Tabanidae are potent vectors of human and animal diseases, but they have not been thoroughly investigated to date. In Senegal (West Africa), little information is available on these dipterans.
Mohamed Lamine Keita +4 more
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Background Clostridium perfringens is a key pathogen in poultry-associated necrotic enteritis (NE). To date there are limited Whole Genome Sequencing based studies describing broiler-associated C. perfringens in healthy and diseased birds.
Raymond Kiu +8 more
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Florian Maderspacher introduces the microbiology special issue and asks how the study of microbes has shaped our understanding of evolution.
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GeneDB and Wikidata [version 2; peer review: 2 approved]
Publishing authoritative genomic annotation data, keeping it up to date, linking it to related information, and allowing community annotation is difficult and hard to support with limited resources. Here, we show how importing GeneDB annotation data into
Magnus Manske +3 more
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Background Recent studies suggested the existence of (poly-)microbial infections in human brains. These have been described either as putative pathogens linked to the neuro-inflammatory changes seen in Parkinson’s disease (PD) and Alzheimer’s disease (AD)
Janis R. Bedarf +7 more
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Competition assays are a simple phenotyping strategy that confront two bacterial strains to evaluate their relative fitness. Because they are more accurate than single-strain growth assays, competition assays can be used to highlight slight differences ...
Julien LUNEAU +3 more
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Producing polished prokaryotic pangenomes with the Panaroo pipeline
Population-level comparisons of prokaryotic genomes must take into account the substantial differences in gene content resulting from horizontal gene transfer, gene duplication and gene loss.
Gerry Tonkin-Hill +13 more
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