Results 61 to 70 of about 30,368 (210)

Implantable Microarray Patch: Engineering at the Nano and Macro Scale for Sustained Therapeutic Release via Synthetic Biodegradable Polymers

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
This review focuses on the application of synthetic biodegradable microarray patches (MAPs) in sustained drug delivery. Compared to conventional MAPs which release drugs into the skin in an immediate manner, these implantable MAPs release drugs into skin microcirculation gradually as the biodegradable polymers degrade, thus offering sustained release ...
Li Zhao, Akmal Hidayat Bin Sabri, Mary B. McGuckin, Linlin Li, Zihao Wang, Eneko Larrañeta, Ryan F. Donnelly   +6 more
wiley   +1 more source

Hydrolyzates of fish scales consisting of biologically active supplements for athletes

Известия ТИНРО, 2014
The principal component of protein-carbohydrate mixtures for sports nutrition (gainers) are active peptides, usually synthetic ones. New biologically active supplements-gainers are introduced, which use hydrolyzates of fish scales as the active peptides.
Olga Ya. Mezenova, Natalia Yu. Mezenova, Larisa S. Baydalinova   +2 more
doaj   +1 more source

Placental syncytiotrophoblast constitutes a major barrier to vertical transmission of Listeria monocytogenes. [PDF]

, 2010
Listeria monocytogenes is an important cause of maternal-fetal infections and serves as a model organism to study these important but poorly understood events. L.
A Beham, A Le Monnier, A Moffett, A Shen, AI Bakardjiev, AI Bakardjiev, AI Bakardjiev, AJ Teberg, AM Carter, Anna I. Bakardjiev, AV Lallemand, B Swaminathan, BF King, C Coutifaris, C Floridon, C Kocks, C Sundstrom, CA Kirkbride, CD Ockleford, DA Drevets, DA Drevets, DA Portnoy, DA Portnoy, David S. Schneider, DK Bishop, E Maidji, E Mylonakis, EG Pamer, G Scheuner, H Bierne, H Koi, HM Cobe, IJ Glomski, J Mengaud, J Skoble, J Trowsdale, JA Theriot, Jennifer R. Robbins, JR Robbins, K Benirschke, K Red-Horse, K Red-Horse, Kasia M. Skrzypczynska, KS Kim, L Forner, L Vicovac, LG Tilney, LM Brown, M Berryman, M Lecuit, M Lecuit, M Lecuit, M O'Riordan, M Pentecost, Mirhan Kapidzic, NM Hunkapiller, O Disson, O Genbacev, O Genbacev, O Genbacev, P Cossart, PB Medawar, PD Barnes, PM Drake, RK Miller, RL Goldenberg, S Fisher, S Jones, S Kaur, S Notermans, SJ Cantle, SJ Fisher, SJ Fisher, SR Sooranna, T Kajii, T Rajabian, T Wollert, TH Schiebler, Varvara B. Zeldovich, Y Huang, Y Shen, Y Zhou, Z Vacek   +82 more
core   +3 more sources

Western Diet Inhibits FUT7‐Mediated Treg Intestinal Homing to Disrupt the Homeostasis of Intestinal Epithelial Cells in Crohn's Disease

Advanced Science, EarlyView.
In this study, we constructed a nanoparticle that was CD4 antibody‐mediated targeted, Fut7‐expressing plasmid‐loaded cationic liposome, namely CD4‐LDP‐Fut7. Upregulation of Fut7 expression in Tregs by using CD4‐LDP‐Fut7 can increase Treg homing to the intestine, thereby facilitating repair of the intestinal epithelial barrier and inhibiting ...
Qian Zhou, Xianfei Wang, Teng Ben, Chunping Zhu, Xinlong Lin, Yinmu Li, Xinyue Zhang, Yeling Chen, Yuchen Xuan, Huaiwen Chen, Ke Liu, Fang Wu, Yuexin Ren, Gao Tan   +13 more
wiley   +1 more source

Collagenase is a major gene product of induced rabbit synovial fibroblasts. [PDF]

, 1984
We have investigated the effects of the tumor-promoting phorbol diester, 12-O-tetradecanoylphorbol-13-acetate (TPA), on rabbit synovial fibroblasts, and found that this agent induced a major switch in gene expression in these cells that was marked by the
Aggeler, J, Frisch, SM, Werb, Z
core  

Elemene Augments the Effects of Anti‐PD‐1 Immunotherapy on Hepatocellular Carcinoma by Regulating the miR‐130a‐5p/SPP/MHC‐I Axis

Advanced Science, EarlyView.
Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang, Mengqing Sun, Heng Dong, Xiaoting Zhang, Jingbo Zhang, Zhengguo Zhang, Mengjie Ni, Lina Li, Yunxin Pei, Xiaoyu Chen, Qian Li, Fangtian Bu, Jiacheng Huang, Liangyu Jiang, Zhuting Fang, Xuliang Chen, Jianxiang Chen, Yiting Qiao, Tian Xie   +18 more
wiley   +1 more source

Extracellular Vesicles of Streptococcus anginosus Mediate Gastritis via Epithelial Barrier Disruption and Macrophage‐driven Inflammation

Advanced Science, EarlyView.
Streptococcus anginosus extracellular vesicles (SA‐EVs) accumulate in gastric tissue, disrupt epithelial tight junctions, and induce gastritis characterized by neutrophil infiltration and elevated cytokines (TNF‐α, IL‐6, IL‐17A). Proteomics identifies TMPC and FBP62 as key SA‐EVs virulence factors; their genetic deletion attenuates inflammation ...
Ying Gong, Lina Duan, Jie Xiao, Yulu Deng, Hongxia Wang, Yajie Zhang, Xiumei Hu, Haifang Wang, Taixue An, Xin Li, Yurong Qiu, Lei Zheng, Haixia Li   +12 more
wiley   +1 more source

Evaluation of Biotechnological Active Peptides Secreted by Saccharomyces cerevisiae with Potential Skin Benefits

Antibiotics
Biotechnological active peptides are gaining interest in the cosmetics industry due to their antimicrobial, anti-inflammatory, antioxidant, and anti-collagenase (ACE) effects, as well as wound healing properties, making them suitable for cosmetic ...
Elisabete Muchagato Maurício, Patrícia Branco, Ana Luiza Barros Araújo, Catarina Roma-Rodrigues, Katelene Lima, Maria Paula Duarte, Alexandra R. Fernandes, Helena Albergaria   +7 more
doaj   +1 more source

Detection and diversity of a putative novel heterogeneous polymorphic proline-glycine repeat (Pgr) protein in the footrot pathogen Dichelobacter nodosus [PDF]

, 2010
Dichelobacter nodosus, a Gram-negative anaerobic bacterium, is the essential causative agent of footrot in sheep. Currently, depending on the clinical presentation in the field, footrot is described as benign or virulent; D.
Atiya Ul-Hassan, Buller, Bzymek, Cheetham, Claire L. Russell, Claxton, Depiazzi, Elizabeth M.H. Wellington, Girard, Graham F. Medley, Gravekamp, Gravekamp, Heise, Hindmarsh, Jasmeet Kaler, Jelinek, Jordan, Julian I. Rood, Katz, Katz, Kay, Kennan, Kennan, La Fontaine, Ladefoged, Laura E. Green, Leo A. Calvo-Bado, Lukomski, Madoff, Moore, Myers, Nallapareddy, Nicky Buller, O’Dushlaine, Palmer, Paterson, Pringle, Puopolo, Rasmussen, Romero, Rood, Rose Grogono-Thomas, Ruth M. Kennan, Vanhoof, Verstrepen, Williamson, Yong, Zhang   +47 more
core   +4 more sources

NAD+‐Dependent Enzyme SIRT3 Limits Intestinal Epithelial Cell Functions Through NAD+ Synthesis Pathway in Colorectal Cancer

Advanced Science, EarlyView.
Microbiota‐derived quinolinic acid is used as an alternative source of replenishing the intracellular NAD+ pool induced by SIRT3 deficiency to regulate intestinal epithelial cell and T cell function, which has implications for targeting intestinal epithelial cells as an approach to the treatment of immune‐associated diseases, including colorectal ...
Ruiying Niu, Yingjie Dong, Jianghui Tong, Jingxuan Xia, Longhao Zhao, Zi Geng, Yingxin Lin, Jinghe Zhang, Xinyi Liu, Manqi Fang, Xi Jin, Yujing Bi, Guangwei Liu   +12 more
wiley   +1 more source