Results 81 to 90 of about 49,765 (301)

Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery

Advanced Science, EarlyView.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source

Using Fungi in Artificial Microbial Consortia to Solve Bioremediation Problems

Microorganisms
There is currently growing interest in the creation of artificial microbial consortia, especially in the field of developing and applying various bioremediation processes.
Elena Efremenko, Nikolay Stepanov, Olga Senko, Aysel Aslanli, Olga Maslova, Ilya Lyagin   +5 more
doaj   +1 more source

Metatranscriptomic Sequencing of a Cyanobacterial Soil-Surface Consortium with and without a Diverse Underlying Soil Microbiome. [PDF]

, 2020
Soil surface consortia are easily observed and sampled, allowing examination of their interactions with soil microbiomes. Here, we present metatranscriptomic sequences from Dark Green 1 (DG1), a cyanobacterium-based soil surface consortium, in the ...
Bell, Terrence H, Bruns, Mary Ann, Clum, Alicia, Copeland, Alex, Daum, Chris, Eloe-Fadrosh, Emiley A, Foster, Brian, Foster, Bryce, Huntemann, Marcel, Ivanova, Natalia N, Kyrpides, Nikos C, Mukherjee, Supratim, Palaniappan, Krishnaveni, Peng, Xin, Pennacchio, Christa, Reddy, TBK, Roux, Simon, Trexler, Ryan V, Varghese, Neha   +18 more
core  

Evidence of microbial activity from a shallow water whale fall (Voghera, northern Italy) [PDF]

, 2012
The fossil bones, associated carbonate cements and enclosing concretion of a Miocene mysticete from inner shelf deposits (Monte Vallassa Formation, northern Italy) were analyzed for evidence of microbial activity. Optical and scanning electron microscopy,
Cavalazzi, B, Danise, S, Dominici, S, Guioli, S, Monechi, S, Westall, F   +5 more
core   +4 more sources

Polydopamine‐Encapsulated Probiotics Restore Gut Homeostasis and Reinstate Macrophage Efferocytosis in Systemic Lupus Erythematosus

Advanced Science, EarlyView.
Polydopamine‐encapsulated probiotics restore gut homeostasis and reinstate macrophage efferocytosis, thereby reestablishing immune tolerance and mitigating systemic autoimmunity, highlighting a bioengineered microbiota‐based therapeutic strategy for SLE.
Ruimiao Wu, Mei Liu, Changxing Gao, Cheng Zhao, Feijie Zhao, Shuqing Dong, Bo Zhang, Qianmei Liu, Wenqian Zhang, Ming Zhao, Qianjin Lu   +10 more
wiley   +1 more source

Effect of Ethanol on Microbial Community Structure and Function During Natural Attenuation of Benzene, Toluene, and \u3cem\u3eo\u3c/em\u3e-Xylene in a Sulfate-reducing Aquifer [PDF]

, 2008
Ethanol (EtOH) is a commonly used fuel oxygenate in reformulated gasoline and is an alternative fuel and fuel supplement. Effects of EtOH release on aquifer microbial ecology and geochemistry have not been well characterized in situ.
Chakraborty, Irina, de Sieyes, Nick, Einarson, Murray, Feris, Kevin, Hristova, Krassimira R., Mackay, Doug, Scow, Kate M.   +6 more
core   +1 more source

Selection, Succession, and Stabilization of Soil Microbial Consortia

mSystems, 2019
The soil microbiome carries out important ecosystem functions, but interactions between soil microbial communities have been difficult to study due to the high microbial diversity and complexity of the soil habitat. In this study, we successfully obtained stable consortia with reduced complexity that contained species found in the original source soil.
Elias K. Zegeye, Colin J. Brislawn, Yuliya Farris, Sarah J. Fansler, Kirsten S. Hofmockel, Janet K. Jansson, Aaron T. Wright, Emily B. Graham, Dan Naylor, Ryan S. McClure, Hans C. Bernstein   +10 more
openaire   +4 more sources

Flipping DNA to Generate and Regulate Microbial Consortia [PDF]

Genetics, 2010
AbstractCommunities of interdependent microbes, found in diverse natural contexts, have recently attracted the attention of bioengineers. Such consortia have potential applications in biosynthesis, with metabolic tasks distributed over several phenotypes, and in live-cell microbicide therapies where phenotypic diversity might aid in immune evasion ...
Rohini, Ramadas, Mukund, Thattai
openaire   +2 more sources

Methane Generation Using an Anaerobic Biodigester From Waste Leachate Water

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Leachate wastewater (LWW) is characterized by slow biodegradation and low biogas production due to resistant materials and limited biological activity. Therefore, applying pretreatments is essential to improving biodegradation potential, which consequently boosts energy recovery.
Khairi R. Kalash, Nisreen S. Ali, Mustafa H. Al‐Furaiji, Mahir A. Abdulrahman, Talib M. Albayati, Buthainah Ali Al‐Timimi   +5 more
wiley   +1 more source

Microbial consortia of biological products: Do they have a future?

Biological Control
Beneficial microbes play crucial role in modern agriculture, serving as biopesticides, biostimulants/biofertilizers, and alleviating abiotic stress in crops.
Peterson S.O. Nunes, Gileno V. Lacerda-Junior, Gabriel M. Mascarin, Rafaela A. Guimarães, Flavio H.V. Medeiros, Steven Arthurs, Wagner Bettiol   +6 more
doaj   +1 more source