Results 61 to 70 of about 652,986 (356)

Development of a lysine biosensor for the dynamic regulation of cadaverine biosynthesis in E. coli

Microbial Cell Factories
Background As one of the most promising monomers of biobased polyamides, cadaverine has wide industrial application prospects. However, in microbial cadaverine fermentation with glucose as the sole carbon source, the impaired coordination between ...
Mingjie Li, Haorong Chen, Yukun Chen, Pengyu Chen, Shuchun Liu, Shuwen Liu, Tingyi Wen   +6 more
doaj   +1 more source

New bioactive secondary metabolites from fungi: 2024

Mycology
Fungi have been recognised as a prolific source of structurally unique secondary metabolites with promising pharmacological properties. This review comprehensively summarises the chemical architectures, bioactivities, and research strategies for new ...
Meiyan Bao, Ying Shi, Xiaoyi Gong, Yutong Guo, Jing Wang, Xiaofei Chen, Ling Liu   +6 more
doaj   +1 more source

Microbial Diversity of Marine Sponges [PDF]

, 2003
The recent application of molecular microbial ecology tools to sponge-microbe associations has revealed a glimpse into the biodiversity of these microbial communities, that is considered just 'the tip of the iceberg'. This chapter provides an overview over these new findings with regard to identity, diversity and distribution patterns of sponge ...
U, Hentschel, L, Fieseler, M, Wehrl, C, Gernert, M, Steinert, J, Hacker, M, Horn   +6 more
openaire   +2 more sources

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

New antifungal chlorinated orsellinic aldehydes from the deep-sea-derived fungus Acremonium sclerotigenum LW14

Mycology
Two new pairs of chlorinated orsellinic aldehyde enantiomers acresorcinols A and B (1a/1b and 2a/2b), and three orsellinic aldehydes, acresorcinols C−E (3−5) were discovered from the extract of the deep-sea-derived fungus Acremonium sclerotigenum LW14 ...
Ruiyun Huo, Yu Tu, Chang Liu, Guangrong Zi, Ying Shi, Jinwei Ren, Lei Cai, Ling Liu   +7 more
doaj   +1 more source

The evolution of morphological development is congruent with the species phylogeny in the genus Streptomyces

Frontiers in Microbiology, 2023
As the canonical model organism to dissect bacterial morphological development, Streptomyces species has attracted much attention from the microbiological society. However, the evolution of development-related genes in Streptomyces remains elusive. Here,
Min Wang, Min Wang, Cong-Jian Li, Zhen Zhang, Pan-Pan Li, Ling-Ling Yang, Xiao-Yang Zhi   +6 more
doaj   +1 more source

Dietary bioactive lipid compounds rich in menthol alter Interactions among members of ruminal microbiota in sheep [PDF]

, 2019
This study aimed to investigate the effects of two practically relevant doses of menthol-rich plant bioactive lipid compounds (PBLC) on fermentation, microbial community composition, and their interactions in sheep rumen.
Aschenbach, Jörg R., Braun, Hannah-Sophie, Geiger, Sebastian, Park, Tansol, Patra, Amlan K., Pieper, Robert, Yu, Zhongtang   +6 more
core   +1 more source

Energetic and Environmental Constraints on the Community Structure of Benthic Microbial Mats in Lake Fryxell, Antarctica. [PDF]

, 2020
Ecological communities are regulated by the flow of energy through environments. Energy flow is typically limited by access to photosynthetically active radiation (PAR) and oxygen concentration (O2).
Dillon, Megan L, Doran, Peter T, Eisen, Jonathan A, Hawes, Ian, Jungblut, Anne D, Mackey, Tyler J, Sumner, Dawn Y   +6 more
core   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source